FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1588329518> ?p ?o ?g. }

• W1588329518 endingPage "45" @default.
• W1588329518 startingPage "537" @default.
• W1588329518 abstract "To determine whether iron homeostasis disorder accompanies retinal degeneration in Royal College of Surgeons (RCS) rats.The presence of iron was revealed directly by proton-induced X-ray emission (PIXE) and indirectly by electron microscopy (EM). Ferritin, transferrin (Tf), and transferrin receptor (Tf-R) were localized by immunohistochemistry. Ferritin and Tf proteins were analyzed by Western blot analysis. Comparative study of Tf-R content was performed by slot-blot analysis and ferritin content was evaluated by enzyme-linked immunosorbent assay (ELISA). Ferritin and Tf-R expression was studied by reverse transcription-polymerase chain reaction (RT-PCR) and Tf expression by in situ hybridization (ISH). All studies were performed in RCS and control retinas from postnatal days (PN)20 to PN55.PIXE analysis showed iron accumulation in outer retina of RCS rats in a time-dependent manner. EM studies revealed irregular iron inclusions on partially degenerated outer segments (OS) of photoreceptors and lamellar whorls at PN35 and very large iron deposits on membranes from a debris layer at PN55. No such deposits were found in the inner retina. Ferritin and Tf-R expression and protein levels seemed to be unaffected in the inner part of the retina. Iron accumulation was preceded by Tf degradation, as revealed by immunohistochemistry and Western blot analysis. Tf mRNA was detected in RCS rat retinal pigment epithelium (RPE) at all stages studied.This study presents the first evidence for a correlation of iron homeostasis imbalance with the neurodegenerative state of the retina in RCS rats. The iron imbalance is not the underlying genetic defect but is the result of impaired RPE-photoreceptor interaction, which leads to debris accumulation and subsequent blockage of the outer retina's iron delivery pathway. The increase of iron in the photoreceptor area may enhance the vulnerability of cells to oxidative stress." @default.
• W1588329518 created "2016-06-24" @default.
• W1588329518 creator A5010331554 @default.
• W1588329518 creator A5036188179 @default.
• W1588329518 creator A5040048319 @default.
• W1588329518 creator A5055617844 @default.
• W1588329518 creator A5077386184 @default.
• W1588329518 creator A5077475886 @default.
• W1588329518 creator A5082379675 @default.
• W1588329518 date "2002-02-01" @default.
• W1588329518 modified "2023-09-30" @default.
• W1588329518 title "Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats." @default.
• W1588329518 cites W149892685 @default.
• W1588329518 cites W1507327514 @default.
• W1588329518 cites W150892060 @default.
• W1588329518 cites W1511794096 @default.
• W1588329518 cites W1602998522 @default.
• W1588329518 cites W1605011464 @default.
• W1588329518 cites W160799879 @default.
• W1588329518 cites W163817165 @default.
• W1588329518 cites W165421384 @default.
• W1588329518 cites W176206161 @default.
• W1588329518 cites W1972860853 @default.
• W1588329518 cites W1975436727 @default.
• W1588329518 cites W1981481645 @default.
• W1588329518 cites W1986880288 @default.
• W1588329518 cites W1994934436 @default.
• W1588329518 cites W1999236279 @default.
• W1588329518 cites W2003090355 @default.
• W1588329518 cites W2021669876 @default.
• W1588329518 cites W2022848089 @default.
• W1588329518 cites W2029650842 @default.
• W1588329518 cites W2043185568 @default.
• W1588329518 cites W2047097816 @default.
• W1588329518 cites W2072704848 @default.
• W1588329518 cites W2084432680 @default.
• W1588329518 cites W2088987937 @default.
• W1588329518 cites W2100837269 @default.
• W1588329518 cites W2109197086 @default.
• W1588329518 cites W2109343416 @default.
• W1588329518 cites W2110864849 @default.
• W1588329518 cites W2126577146 @default.
• W1588329518 cites W2128294582 @default.
• W1588329518 cites W2158254997 @default.
• W1588329518 cites W2192992187 @default.
• W1588329518 cites W2227187219 @default.
• W1588329518 cites W2400604098 @default.
• W1588329518 cites W2416895004 @default.
• W1588329518 cites W51237493 @default.
• W1588329518 cites W2064869564 @default.
• W1588329518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11818402" @default.
• W1588329518 hasPublicationYear "2002" @default.
• W1588329518 type Work @default.
• W1588329518 sameAs 1588329518 @default.
• W1588329518 citedByCount "29" @default.
• W1588329518 countsByYear W15883295182012 @default.
• W1588329518 countsByYear W15883295182013 @default.
• W1588329518 countsByYear W15883295182017 @default.
• W1588329518 countsByYear W15883295182018 @default.
• W1588329518 countsByYear W15883295182019 @default.
• W1588329518 countsByYear W15883295182020 @default.
• W1588329518 countsByYear W15883295182022 @default.
• W1588329518 countsByYear W15883295182023 @default.
• W1588329518 crossrefType "journal-article" @default.
• W1588329518 hasAuthorship W1588329518A5010331554 @default.
• W1588329518 hasAuthorship W1588329518A5036188179 @default.
• W1588329518 hasAuthorship W1588329518A5040048319 @default.
• W1588329518 hasAuthorship W1588329518A5055617844 @default.
• W1588329518 hasAuthorship W1588329518A5077386184 @default.
• W1588329518 hasAuthorship W1588329518A5077475886 @default.
• W1588329518 hasAuthorship W1588329518A5082379675 @default.
• W1588329518 hasConcept C104317684 @default.
• W1588329518 hasConcept C105580179 @default.
• W1588329518 hasConcept C142724271 @default.
• W1588329518 hasConcept C153911025 @default.
• W1588329518 hasConcept C169760540 @default.
• W1588329518 hasConcept C185592680 @default.
• W1588329518 hasConcept C203014093 @default.
• W1588329518 hasConcept C204232928 @default.
• W1588329518 hasConcept C22814914 @default.
• W1588329518 hasConcept C2776415932 @default.
• W1588329518 hasConcept C2777093970 @default.
• W1588329518 hasConcept C2778024200 @default.
• W1588329518 hasConcept C2778319317 @default.
• W1588329518 hasConcept C2780827179 @default.
• W1588329518 hasConcept C32264632 @default.
• W1588329518 hasConcept C55493867 @default.
• W1588329518 hasConcept C71924100 @default.
• W1588329518 hasConcept C81439078 @default.
• W1588329518 hasConcept C85265743 @default.
• W1588329518 hasConcept C86803240 @default.
• W1588329518 hasConceptScore W1588329518C104317684 @default.
• W1588329518 hasConceptScore W1588329518C105580179 @default.
• W1588329518 hasConceptScore W1588329518C142724271 @default.
• W1588329518 hasConceptScore W1588329518C153911025 @default.
• W1588329518 hasConceptScore W1588329518C169760540 @default.
• W1588329518 hasConceptScore W1588329518C185592680 @default.
• W1588329518 hasConceptScore W1588329518C203014093 @default.

• next