Matches in SemOpenAlex for { <https://semopenalex.org/work/W1588393313> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1588393313 endingPage "529" @default.
- W1588393313 startingPage "525" @default.
- W1588393313 abstract "Cathinone derivatives display a wide range of pharmacological activities and uses; some of them are used as prescription medicines, while others are encountered within a recreational context and are available without a prescription over the Internet and in retail shops around the world. One of the difficulties involved in the unambiguous identification of these new psychoactive substances is the lack of suitable reference standards, particularly when dealing with unreported derivatives and positional isomers. In order to address this need, three trifluoromethyl analogues of the psychostimulant methcathinone, with a CF(3) substituent at the 2-, 3- and 4-position of the phenyl ring (2-TFMAP 1, 3-TFMAP 2 and 4-TFMAP 3), have been prepared for analytical characterization using ATR-FTIR, (1)H and (13) C NMR, and GC-(EI/CI)-ion trap-MS. Differentiation among isomers was feasible by IR, for example when assessing the carbonyl stretch at 1711 (1), 1693 (2) and 1688 (3) cm(-1) , respectively. In addition to the expected iminium base peak at m/z 58, EI-MS displayed key ions at m/z 173, 145, 125, 95, and 75. Separation of isomers was possible under GC conditions. A characteristic feature under CI conditions was the loss of water from the [M + H](+) yielding m/z 214 in addition to m/z 58. Studies currently underway show that the three CF(3) -methcathinone analogues have central nervous system effects and that the 4-CF(3) isomer 3 is more potent as a serotonin uptake inhibitor and releasing agent than the 3-CF(3) and 2-CF(3) counterparts." @default.
- W1588393313 created "2016-06-24" @default.
- W1588393313 creator A5005457342 @default.
- W1588393313 creator A5008337734 @default.
- W1588393313 creator A5037184848 @default.
- W1588393313 date "2012-02-24" @default.
- W1588393313 modified "2023-10-16" @default.
- W1588393313 title "Analytical characterization of three trifluoromethyl-substituted methcathinone isomers" @default.
- W1588393313 cites W1986031690 @default.
- W1588393313 cites W1990629681 @default.
- W1588393313 cites W1992048606 @default.
- W1588393313 cites W1998852714 @default.
- W1588393313 cites W2054598364 @default.
- W1588393313 cites W2093141375 @default.
- W1588393313 cites W2125965195 @default.
- W1588393313 cites W2131432176 @default.
- W1588393313 cites W2134133603 @default.
- W1588393313 cites W2138188415 @default.
- W1588393313 cites W2153912889 @default.
- W1588393313 cites W2156989674 @default.
- W1588393313 cites W2167085007 @default.
- W1588393313 cites W4243307001 @default.
- W1588393313 doi "https://doi.org/10.1002/dta.382" @default.
- W1588393313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22362591" @default.
- W1588393313 hasPublicationYear "2012" @default.
- W1588393313 type Work @default.
- W1588393313 sameAs 1588393313 @default.
- W1588393313 citedByCount "21" @default.
- W1588393313 countsByYear W15883933132012 @default.
- W1588393313 countsByYear W15883933132013 @default.
- W1588393313 countsByYear W15883933132015 @default.
- W1588393313 countsByYear W15883933132016 @default.
- W1588393313 countsByYear W15883933132017 @default.
- W1588393313 countsByYear W15883933132018 @default.
- W1588393313 countsByYear W15883933132019 @default.
- W1588393313 countsByYear W15883933132020 @default.
- W1588393313 countsByYear W15883933132021 @default.
- W1588393313 countsByYear W15883933132023 @default.
- W1588393313 crossrefType "journal-article" @default.
- W1588393313 hasAuthorship W1588393313A5005457342 @default.
- W1588393313 hasAuthorship W1588393313A5008337734 @default.
- W1588393313 hasAuthorship W1588393313A5037184848 @default.
- W1588393313 hasConcept C145148216 @default.
- W1588393313 hasConcept C151730666 @default.
- W1588393313 hasConcept C15744967 @default.
- W1588393313 hasConcept C169760540 @default.
- W1588393313 hasConcept C178790620 @default.
- W1588393313 hasConcept C185592680 @default.
- W1588393313 hasConcept C202235601 @default.
- W1588393313 hasConcept C2776442012 @default.
- W1588393313 hasConcept C2777193897 @default.
- W1588393313 hasConcept C2778236026 @default.
- W1588393313 hasConcept C2778567177 @default.
- W1588393313 hasConcept C2778689049 @default.
- W1588393313 hasConcept C2779343474 @default.
- W1588393313 hasConcept C2780263894 @default.
- W1588393313 hasConcept C513476851 @default.
- W1588393313 hasConcept C71240020 @default.
- W1588393313 hasConcept C86803240 @default.
- W1588393313 hasConceptScore W1588393313C145148216 @default.
- W1588393313 hasConceptScore W1588393313C151730666 @default.
- W1588393313 hasConceptScore W1588393313C15744967 @default.
- W1588393313 hasConceptScore W1588393313C169760540 @default.
- W1588393313 hasConceptScore W1588393313C178790620 @default.
- W1588393313 hasConceptScore W1588393313C185592680 @default.
- W1588393313 hasConceptScore W1588393313C202235601 @default.
- W1588393313 hasConceptScore W1588393313C2776442012 @default.
- W1588393313 hasConceptScore W1588393313C2777193897 @default.
- W1588393313 hasConceptScore W1588393313C2778236026 @default.
- W1588393313 hasConceptScore W1588393313C2778567177 @default.
- W1588393313 hasConceptScore W1588393313C2778689049 @default.
- W1588393313 hasConceptScore W1588393313C2779343474 @default.
- W1588393313 hasConceptScore W1588393313C2780263894 @default.
- W1588393313 hasConceptScore W1588393313C513476851 @default.
- W1588393313 hasConceptScore W1588393313C71240020 @default.
- W1588393313 hasConceptScore W1588393313C86803240 @default.
- W1588393313 hasIssue "6" @default.
- W1588393313 hasLocation W15883933131 @default.
- W1588393313 hasLocation W15883933132 @default.
- W1588393313 hasOpenAccess W1588393313 @default.
- W1588393313 hasPrimaryLocation W15883933131 @default.
- W1588393313 hasRelatedWork W1980175269 @default.
- W1588393313 hasRelatedWork W2112147319 @default.
- W1588393313 hasRelatedWork W2136584054 @default.
- W1588393313 hasRelatedWork W2507950443 @default.
- W1588393313 hasRelatedWork W2523237080 @default.
- W1588393313 hasRelatedWork W2572049434 @default.
- W1588393313 hasRelatedWork W2597486713 @default.
- W1588393313 hasRelatedWork W2899896230 @default.
- W1588393313 hasRelatedWork W2951120459 @default.
- W1588393313 hasRelatedWork W3021295996 @default.
- W1588393313 hasVolume "4" @default.
- W1588393313 isParatext "false" @default.
- W1588393313 isRetracted "false" @default.
- W1588393313 magId "1588393313" @default.
- W1588393313 workType "article" @default.