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• W1588420904 abstract "The gastric mucosal immune response is thought to be comprised predominantly of the Th1 type; however, there are limited data regarding the role of IL-18 in Helicobacter pylori -induced inflammation. We investigated IL-18 levels in gastric mucosal biopsy specimens as well as in isolated gastric epithelial cells and lamina propria mononuclear cells. We also investigated IL-18 levels in gastric epithelial cells and the monocyte cell line THP-1 cocultured with H. pylori . In both systems, IL-18 levels were markedly enhanced in H. pylori -infected epithelial cells and monocytes. IL-18 levels in H. pylori -infected gastric mucosa were well correlated with the severity of gastric inflammation, confirming that H. pylori -induced IL-18 plays an important role in gastric injury. Virulence factors of H. pylori ; the cag pathogenicity island and OipA affected IL-18 induction in different manners. Up-regulation of IL-18 mRNA/protein in epithelial cells was dependent on both virulence factors. Interestingly, up-regulation of IL-18 mRNA in monocytes was independent of both factors, whereas IL-18 protein was OipA dependent – cag pathogenicity island independent, indicating that OipA regulates IL-18 induction in monocytes at the posttranscriptional level. IL-18 levels in the gastric biopsy specimens showed similar patterns to those in lamina propria mononuclear cells with respect to virulence factors, suggesting that submucosal monocytes/macrophages are the main source of IL-18 induced by H. pylori infection. H. pylori appeared to regulate the ERK/JNK→AP-1 pathway in both cell types. In addition, OipA and its related p38 pathway may be closely involved in IL-18 induction in H. pylori -infected gastric mucosa and may contribute to gastric injury." @default.
• W1588420904 created "2016-06-24" @default.
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• W1588420904 date "2008-01-04" @default.
• W1588420904 modified "2023-10-16" @default.
• W1588420904 title "Regulation of IL-18 inHelicobacter pyloriInfection" @default.
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• W1588420904 doi "https://doi.org/10.4049/jimmunol.180.2.1207" @default.
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