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- W1588914670 abstract "Despite improvements in management,1 open spina bifida (OSB) remains severely handicapping, associated in almost all patients with paraplegia, impaired bladder, and bowel control, and, in 25%, with IQs of less than 80 (calculated from McLone et al2). Social isolation and diminished self-esteem are observed more frequently in adolescents with OSB than in healthy control subjects.3 The divorce rate among parents of affected children can be high.4 On the order of $70,000 is spent in the lifetime care of a person with OSB, and another $12,000 is lost through diminished productivity.5 With an incidence of approximately one in 2,000 live births in the United States in 1980,6 OSB is one of the most common of all serious congenital malformations." @default.
- W1588914670 created "2016-06-24" @default.
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- W1588914670 date "1983-04-01" @default.
- W1588914670 modified "2023-10-16" @default.
- W1588914670 title "Prenatal Screening for Neural Tube Defects" @default.
- W1588914670 doi "https://doi.org/10.1542/peds.71.4.658" @default.
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