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- W1589200083 startingPage "541" @default.
- W1589200083 abstract "Chromosomal rearrangements involving the anaplastic lymphoma kinase (ALK) gene were recently identified in patients with nonsmall cell lung cancer (NSCLC). Although found in a small subset of patients, ALK rearrangements define an important model of oncogene-driven NSCLC. ALK rearrangements are associated with specific clinical and pathologic features, such as younger age, adenocarcinoma histology, and lack of smoking history. Screening for ALK rearrangements can be performed using ALK FISH, immunohistochemistry or RT-PCR, though only ALK FISH is clinically validated. Patients with ALK rearrangements are uniquely sensitive to the ALK tyrosine kinase inhibitor crizotinib, which results in high response rates (60%) and a median progression-free survival of over 8 months. The success of crizotinib validates treatment paradigms using molecularly targeted therapies and underscores the value of incorporating tumor genotyping into routine clinical practice." @default.
- W1589200083 created "2016-06-24" @default.
- W1589200083 creator A5080311196 @default.
- W1589200083 creator A5081227348 @default.
- W1589200083 date "2014-04-04" @default.
- W1589200083 modified "2023-10-16" @default.
- W1589200083 title "Targeting <i>ALK</i> Rearrangements" @default.
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- W1589200083 doi "https://doi.org/10.1002/9781118468791.ch35" @default.
- W1589200083 hasPublicationYear "2014" @default.
- W1589200083 type Work @default.