FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1589321067> ?p ?o ?g. }

• W1589321067 endingPage "264" @default.
• W1589321067 startingPage "252" @default.
• W1589321067 abstract "1 Measurements of artery contraction, cytosolic [Ca2+], and Ca2+ permeability were made to examine contractile and cytosolic [Ca2+] responses of canine pulmonary arteries and isolated cells to 5-hydroxytryptamine (5-HT), and to determine the roles of intracellular Ca2+ release and extracellular Ca2+ entry in 5-HT responses. 2 The EC50 for 5-HT-mediated contractions and cytosolic [Ca2+] increases was ∼10−7 M and responses were inhibited by ketanserin, a 5-HT2A-receptor antagonist. 3 5-HT induced cytosolic [Ca2+] increases were blocked by 20 μM Xestospongin-C and by 2-APB (IC50=32 μM), inhibitors of InsP3 receptor activation. 4 5-HT-mediated contractions were reliant on release of InsP3 but not ryanodine-sensitive Ca2+ stores. 5 5-HT-mediated contractions and cytosolic [Ca2+] increases were partially inhibited by 10 μM nisoldipine, a voltage-dependent Ca2+ channel blocker. 6 Extracellular Ca2+ removal reduced 5-HT-mediated contractions further than nisoldipine and ablated cytosolic [Ca2+] increases and [Ca2+] oscillations. Similar to Ca2+ removal, Ni2+ reduced cytosolic [Ca2+] and [Ca2+] oscillations. 7 Mn2+ quench of fura-2 and voltage-clamp experiments showed that 5-HT failed to activate any significant voltage-independent Ca2+ entry pathways, including store-operated and receptor-activated nonselective cation channels. Ni2+ but not nisoldipine or Gd3+ blocked basal Mn2+ entry. 8 Voltage-clamp experiments showed that simultaneous depletion of both InsP3 and ryanodine-sensitive intracellular Ca2+ stores activates a current with linear voltage dependence and a reversal potential consistent with it being a nonselective cation channel. 5-HT did not activate this current. 9 Basal Ca2+ entry, rather than CCE, is important to maintain 5-HT-induced cytosolic [Ca2+] responses and contraction in canine pulmonary artery. British Journal of Pharmacology (2005) 144, 252–264. doi:10.1038/sj.bjp.0706077" @default.
• W1589321067 created "2016-06-24" @default.
• W1589321067 creator A5003198184 @default.
• W1589321067 creator A5003544505 @default.
• W1589321067 creator A5017946350 @default.
• W1589321067 creator A5033692722 @default.
• W1589321067 creator A5056390911 @default.
• W1589321067 creator A5066498895 @default.
• W1589321067 creator A5081004406 @default.
• W1589321067 creator A5082969969 @default.
• W1589321067 date "2005-01-01" @default.
• W1589321067 modified "2023-10-14" @default.
• W1589321067 title "Role of basal extracellular Ca²⁺entry during 5-HT-induced vasoconstriction of canine pulmonary arteries" @default.
• W1589321067 cites W1678757150 @default.
• W1589321067 cites W1899877571 @default.
• W1589321067 cites W190713561 @default.
• W1589321067 cites W1926185647 @default.
• W1589321067 cites W1930917734 @default.
• W1589321067 cites W1971788599 @default.
• W1589321067 cites W1972359486 @default.
• W1589321067 cites W1974342767 @default.
• W1589321067 cites W1975479233 @default.
• W1589321067 cites W1981342910 @default.
• W1589321067 cites W1983672484 @default.
• W1589321067 cites W1983856370 @default.
• W1589321067 cites W1996024251 @default.
• W1589321067 cites W1997511216 @default.
• W1589321067 cites W2009087599 @default.
• W1589321067 cites W2009667219 @default.
• W1589321067 cites W2010762668 @default.
• W1589321067 cites W2015426350 @default.
• W1589321067 cites W2022398918 @default.
• W1589321067 cites W2027725961 @default.
• W1589321067 cites W2033023357 @default.
• W1589321067 cites W2035079270 @default.
• W1589321067 cites W2035427061 @default.
• W1589321067 cites W2048721130 @default.
• W1589321067 cites W2057503806 @default.
• W1589321067 cites W2060510646 @default.
• W1589321067 cites W2068659463 @default.
• W1589321067 cites W2069075656 @default.
• W1589321067 cites W2070541310 @default.
• W1589321067 cites W2073653273 @default.
• W1589321067 cites W2076783121 @default.
• W1589321067 cites W2090530710 @default.
• W1589321067 cites W2092109656 @default.
• W1589321067 cites W2095317716 @default.
• W1589321067 cites W2097033636 @default.
• W1589321067 cites W2098318544 @default.
• W1589321067 cites W2100381069 @default.
• W1589321067 cites W2102204826 @default.
• W1589321067 cites W2108431646 @default.
• W1589321067 cites W2116761531 @default.
• W1589321067 cites W2117312810 @default.
• W1589321067 cites W2124658641 @default.
• W1589321067 cites W2141260882 @default.
• W1589321067 cites W2142704391 @default.
• W1589321067 cites W2148806848 @default.
• W1589321067 cites W2169182236 @default.
• W1589321067 cites W2220650403 @default.
• W1589321067 cites W2225782714 @default.
• W1589321067 cites W2268823139 @default.
• W1589321067 cites W2331587480 @default.
• W1589321067 cites W2399426549 @default.
• W1589321067 cites W2403113055 @default.
• W1589321067 cites W2411815690 @default.
• W1589321067 cites W2412476936 @default.
• W1589321067 cites W2463412101 @default.
• W1589321067 cites W2466129765 @default.
• W1589321067 cites W4256370879 @default.
• W1589321067 doi "https://doi.org/10.1038/sj.bjp.0706077" @default.
• W1589321067 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1575999" @default.
• W1589321067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15655514" @default.
• W1589321067 hasPublicationYear "2005" @default.
• W1589321067 type Work @default.
• W1589321067 sameAs 1589321067 @default.
• W1589321067 citedByCount "27" @default.
• W1589321067 countsByYear W15893210672012 @default.
• W1589321067 countsByYear W15893210672013 @default.
• W1589321067 countsByYear W15893210672014 @default.
• W1589321067 countsByYear W15893210672016 @default.
• W1589321067 countsByYear W15893210672018 @default.
• W1589321067 countsByYear W15893210672021 @default.
• W1589321067 countsByYear W15893210672022 @default.
• W1589321067 crossrefType "journal-article" @default.
• W1589321067 hasAuthorship W1589321067A5003198184 @default.
• W1589321067 hasAuthorship W1589321067A5003544505 @default.
• W1589321067 hasAuthorship W1589321067A5017946350 @default.
• W1589321067 hasAuthorship W1589321067A5033692722 @default.
• W1589321067 hasAuthorship W1589321067A5056390911 @default.
• W1589321067 hasAuthorship W1589321067A5066498895 @default.
• W1589321067 hasAuthorship W1589321067A5081004406 @default.
• W1589321067 hasAuthorship W1589321067A5082969969 @default.
• W1589321067 hasBestOaLocation W15893210671 @default.
• W1589321067 hasConcept C113217602 @default.
• W1589321067 hasConcept C12554922 @default.
• W1589321067 hasConcept C126322002 @default.
• W1589321067 hasConcept C134018914 @default.

• next