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- W158933169 abstract "Aldosterone, the final product of the renin-angiotensin-aldosterone system (RAAS), is traditionally viewed as a regulator of renal sodium and potassium handling, extracellular volume, and blood pressure (). Until a few years ago, the adverse vascular effects of the RAAS have been attributed to angiotensin II (Ang II) (,). However, Ang II is a potent aldosterone secretagogue, and recent human and animal studies suggest that aldosterone also has adverse cardiovascular effects, including microvascular damage, vascular inflammation, oxidative stress, and endothelial dysfunction. This chapter focuses on the adverse effects of aldosterone on the cardiovascular system, kidney, and brain in humans and animals, and describes our current understanding of the underlying mechanisms for this injury." @default.
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- W158933169 date "2007-01-01" @default.
- W158933169 modified "2023-10-05" @default.
- W158933169 title "Aldosterone and Vascular Damage" @default.
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- W158933169 doi "https://doi.org/10.1007/978-1-59259-987-5_7" @default.
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