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- W1589335048 endingPage "e1008895" @default.
- W1589335048 startingPage "e1008895" @default.
- W1589335048 abstract "Co-existing paracellular and transcellular barrier defect in intestinal epithelium was documented in inflammatory bowel disease, celiac disease, and intestinal obstruction. Mechanisms regarding tight junction disruption have been extensively studied; however, limited progress has been made in research on bacterial transcytosis. Densely packed brush border (BB), with cholesterol-based lipid rafts in the intermicrovillous membrane invagination, serves as an ultrastructural barrier to prevent direct contact of luminal microbes with the cellular soma. Evidence in in vitro epithelial cell cultures and in vivo animal models of bowel obstruction and antibiotic-resistant bacterial infection had indicated that nonpathogenic, noninvasive enteric bacteria may hijack the lipid raft-mediated endocytic pathways. Our studies have shown that low dose interferon-gamma (IFNγ) causes long myosin light chain kinase (MLCK)-dependent terminal web (TW) contraction and BB fanning, allowing bacteria to pass through the consequently widened intermicrovillous cleft to be endocytosed via caveolin-associated lipid rafts. Activation of intracellular innate immune receptors by bacteria-containing endosomes may further induce inflammatory and oxidative stress, leading to secondary tight junction damage. The finding of bacterial internalization preceding tight junction damage suggests that abnormal bacterial uptake by epithelial cells may contribute to the initiation or relapse of chronic intestinal inflammation." @default.
- W1589335048 created "2016-06-24" @default.
- W1589335048 creator A5061244621 @default.
- W1589335048 date "2015-02-23" @default.
- W1589335048 modified "2023-10-03" @default.
- W1589335048 title "Commensal bacterial internalization by epithelial cells: An alternative portal for gut leakiness" @default.
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- W1589335048 cites W1631281828 @default.
- W1589335048 cites W1747628444 @default.
- W1589335048 cites W1821089725 @default.
- W1589335048 cites W1826133046 @default.
- W1589335048 cites W1949854172 @default.
- W1589335048 cites W1967003457 @default.
- W1589335048 cites W1968991816 @default.
- W1589335048 cites W1970507036 @default.
- W1589335048 cites W1974546936 @default.
- W1589335048 cites W1977325109 @default.
- W1589335048 cites W1986889683 @default.
- W1589335048 cites W1991441340 @default.
- W1589335048 cites W1997307166 @default.
- W1589335048 cites W1997943249 @default.
- W1589335048 cites W2000179381 @default.
- W1589335048 cites W2001196537 @default.
- W1589335048 cites W2006194008 @default.
- W1589335048 cites W2007095789 @default.
- W1589335048 cites W2009706335 @default.
- W1589335048 cites W2015174250 @default.
- W1589335048 cites W2016924160 @default.
- W1589335048 cites W2018273818 @default.
- W1589335048 cites W2019697704 @default.
- W1589335048 cites W2020762219 @default.
- W1589335048 cites W2021779583 @default.
- W1589335048 cites W2022387897 @default.
- W1589335048 cites W2025132803 @default.
- W1589335048 cites W2031113436 @default.
- W1589335048 cites W2031785664 @default.
- W1589335048 cites W2033457017 @default.
- W1589335048 cites W2038783550 @default.
- W1589335048 cites W2039376541 @default.
- W1589335048 cites W2051619093 @default.
- W1589335048 cites W2052532027 @default.
- W1589335048 cites W2053885903 @default.
- W1589335048 cites W2057714903 @default.
- W1589335048 cites W2061165431 @default.
- W1589335048 cites W2061583677 @default.
- W1589335048 cites W2065605458 @default.
- W1589335048 cites W2065772719 @default.
- W1589335048 cites W2072492789 @default.
- W1589335048 cites W2084407626 @default.
- W1589335048 cites W2084736890 @default.
- W1589335048 cites W2085955533 @default.
- W1589335048 cites W2085966326 @default.
- W1589335048 cites W2089643849 @default.
- W1589335048 cites W2092347839 @default.
- W1589335048 cites W2100059937 @default.
- W1589335048 cites W2102327965 @default.
- W1589335048 cites W2102388558 @default.
- W1589335048 cites W2103536507 @default.
- W1589335048 cites W2104472257 @default.
- W1589335048 cites W2107278839 @default.
- W1589335048 cites W2110207056 @default.
- W1589335048 cites W2111469427 @default.
- W1589335048 cites W2111725588 @default.
- W1589335048 cites W2114738264 @default.
- W1589335048 cites W2128345511 @default.
- W1589335048 cites W2130050698 @default.
- W1589335048 cites W2133388060 @default.
- W1589335048 cites W2141351365 @default.
- W1589335048 cites W2146202162 @default.
- W1589335048 cites W2148439275 @default.
- W1589335048 cites W2154145747 @default.
- W1589335048 cites W2162259618 @default.
- W1589335048 cites W2166863817 @default.
- W1589335048 cites W2169909966 @default.
- W1589335048 cites W2170559615 @default.
- W1589335048 cites W2170863170 @default.
- W1589335048 cites W2171982502 @default.
- W1589335048 cites W2276828633 @default.
- W1589335048 cites W2280815663 @default.
- W1589335048 cites W2314306274 @default.
- W1589335048 cites W2328023807 @default.
- W1589335048 cites W2395194059 @default.
- W1589335048 doi "https://doi.org/10.1080/21688370.2015.1008895" @default.
- W1589335048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4574896" @default.
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- W1589335048 hasPublicationYear "2015" @default.
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