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- W1589762452 abstract "Zonisamide (ZNS, 3-sulfamoylmethyl-1,2-benzisoxazole) was developed by Dainippon Pharma (Osaka, Japan: currently Dainippon Sumitomo Pharma) and is currently used as an antiepileptic drug (AED) in Japan, South Korea, USA and Europe (Seino, 2004; Seino & Leppik, 2007). Indeed, the wide antiepileptic spectrum of ZNS has been established (Brodie, 2004; Karceski et al., 2005; Seino, 2004; Seino & Leppik, 2007; Willmore, 2004). Several clinical studies have also reported the wide clinical spectrum of ZNS against psychiatric and non-epileptic neurological disorders, including mood disorders (Ghaemi et al., 2008; Ghaemi et al., 2006; Kanba et al., 1994; McElroy et al., 2005), essential tremors (Bermejo, 2007), and its protective effects against ischemic cerebral damage (Willmore, 2004) and Parkinson’s disease (Murata, 2004; Murata et al., 2007). In Japan, ZNS was approved for Parkinson’s disease in 2009 by the Ministry of Health, Labor and Welfare. In this chapter, we review the dose-dependent effects of ZNS on neurotransmission and differences in the mechanisms underlying its antiepileptic and antiparkinsonian effects." @default.
- W1589762452 created "2016-06-24" @default.
- W1589762452 creator A5038118464 @default.
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- W1589762452 date "2011-09-22" @default.
- W1589762452 modified "2023-10-17" @default.
- W1589762452 title "Different Mechanisms Underlying the Antiepileptic and Antiparkinsonian Effects of Zonisamide" @default.
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- W1589762452 doi "https://doi.org/10.5772/19562" @default.
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