FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1589803113> ?p ?o ?g. }

• W1589803113 endingPage "541" @default.
• W1589803113 startingPage "535" @default.
• W1589803113 abstract "Downbeat nystagmus (DBN) is the most frequent form of acquired persisting fixation nystagmus. It is hypothesized to occur when physiological inhibitory cerebellar input, namely of the flocculus, to the vestibular nuclei is inhibited. The second most frequent form of acquired nystagmus is upbeat nystagmus (UBN). UBN is probably caused by an imbalance of vertical vestibulo-ocular reflex tone. GABA-ergic substances like baclofen have been used to treat DBN and UBN, but they have had only moderate success. Animal experiments have shown that aminopyridines [3,4-diaminopyridine (3,4-DAP) and 4-aminopyridine (4-AP)], nonselective blockers of the Kv family of voltage-gated potassium channels, increase Purkinje-cell (PC) excitability. It was assumed that such enhancement of PC activity could restore to normal levels the inhibitory influence of the cerebellar cortex on vertical eye movements. On the basis of these assumptions, we evaluated the efficacy and underlying mechanisms of aminopyridines in DBN and UBN as well as in another cerebellar disorder with an impaired PC function: episodic ataxia type 2 (EA2), which is caused by mutations of the PQ-calcium channel. In a placebo-controlled trial on 17 patients we demonstrated that 3,4-DAP significantly reduces the intensity of DBN. This was confirmed in a recent study with 4-AP, which also showed that 4-AP restores gaze-holding ability independently of fixation in DBN. The efficacy of 4-AP in UBN was demonstrated in single patients. Finally, in an open trial on three patients with EA2 we showed that 4-AP prevents attacks of ataxia. This was also found in an animal model (the tottering mouse) of EA2. The clinical efficacy of 4-AP in EA2 is being further evaluated in an ongoing randomized controlled crossover trial. In conclusion, the use of aminopyridines in DBN, UBN, and EA2 is a new treatment principle for vestibular, cerebellar, and ocular motor disorders." @default.
• W1589803113 created "2016-06-24" @default.
• W1589803113 creator A5036055961 @default.
• W1589803113 creator A5036924687 @default.
• W1589803113 creator A5039921088 @default.
• W1589803113 creator A5051640236 @default.
• W1589803113 creator A5060650180 @default.
• W1589803113 creator A5061687105 @default.
• W1589803113 creator A5078660065 @default.
• W1589803113 date "2008-01-01" @default.
• W1589803113 modified "2023-09-23" @default.
• W1589803113 title "Aminopyridines for the treatment of cerebellar and ocular motor disorders" @default.
• W1589803113 cites W1977497371 @default.
• W1589803113 cites W1981721000 @default.
• W1589803113 cites W1983674470 @default.
• W1589803113 cites W1987349651 @default.
• W1589803113 cites W1987735953 @default.
• W1589803113 cites W2002726417 @default.
• W1589803113 cites W2005765864 @default.
• W1589803113 cites W2006713821 @default.
• W1589803113 cites W2007011463 @default.
• W1589803113 cites W2009748443 @default.
• W1589803113 cites W2012976019 @default.
• W1589803113 cites W2016205798 @default.
• W1589803113 cites W2023879879 @default.
• W1589803113 cites W2025197615 @default.
• W1589803113 cites W2046447715 @default.
• W1589803113 cites W2053978205 @default.
• W1589803113 cites W2068315969 @default.
• W1589803113 cites W2079655307 @default.
• W1589803113 cites W2091102744 @default.
• W1589803113 cites W2091206551 @default.
• W1589803113 cites W2094052841 @default.
• W1589803113 cites W2095682920 @default.
• W1589803113 cites W2123074574 @default.
• W1589803113 cites W2133269887 @default.
• W1589803113 cites W2138416238 @default.
• W1589803113 cites W2138768371 @default.
• W1589803113 cites W2147278989 @default.
• W1589803113 cites W2167538368 @default.
• W1589803113 doi "https://doi.org/10.1016/s0079-6123(08)00676-6" @default.
• W1589803113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18718350" @default.
• W1589803113 hasPublicationYear "2008" @default.
• W1589803113 type Work @default.
• W1589803113 sameAs 1589803113 @default.
• W1589803113 citedByCount "54" @default.
• W1589803113 countsByYear W15898031132012 @default.
• W1589803113 countsByYear W15898031132013 @default.
• W1589803113 countsByYear W15898031132014 @default.
• W1589803113 countsByYear W15898031132015 @default.
• W1589803113 countsByYear W15898031132016 @default.
• W1589803113 countsByYear W15898031132017 @default.
• W1589803113 countsByYear W15898031132018 @default.
• W1589803113 countsByYear W15898031132019 @default.
• W1589803113 countsByYear W15898031132020 @default.
• W1589803113 countsByYear W15898031132021 @default.
• W1589803113 crossrefType "book-chapter" @default.
• W1589803113 hasAuthorship W1589803113A5036055961 @default.
• W1589803113 hasAuthorship W1589803113A5036924687 @default.
• W1589803113 hasAuthorship W1589803113A5039921088 @default.
• W1589803113 hasAuthorship W1589803113A5051640236 @default.
• W1589803113 hasAuthorship W1589803113A5060650180 @default.
• W1589803113 hasAuthorship W1589803113A5061687105 @default.
• W1589803113 hasAuthorship W1589803113A5078660065 @default.
• W1589803113 hasConcept C153050134 @default.
• W1589803113 hasConcept C155647269 @default.
• W1589803113 hasConcept C15744967 @default.
• W1589803113 hasConcept C169760540 @default.
• W1589803113 hasConcept C17077164 @default.
• W1589803113 hasConcept C185592680 @default.
• W1589803113 hasConcept C2779652256 @default.
• W1589803113 hasConcept C2779736392 @default.
• W1589803113 hasConcept C2780148635 @default.
• W1589803113 hasConcept C2780906641 @default.
• W1589803113 hasConcept C2909503537 @default.
• W1589803113 hasConcept C548259974 @default.
• W1589803113 hasConcept C71924100 @default.
• W1589803113 hasConceptScore W1589803113C153050134 @default.
• W1589803113 hasConceptScore W1589803113C155647269 @default.
• W1589803113 hasConceptScore W1589803113C15744967 @default.
• W1589803113 hasConceptScore W1589803113C169760540 @default.
• W1589803113 hasConceptScore W1589803113C17077164 @default.
• W1589803113 hasConceptScore W1589803113C185592680 @default.
• W1589803113 hasConceptScore W1589803113C2779652256 @default.
• W1589803113 hasConceptScore W1589803113C2779736392 @default.
• W1589803113 hasConceptScore W1589803113C2780148635 @default.
• W1589803113 hasConceptScore W1589803113C2780906641 @default.
• W1589803113 hasConceptScore W1589803113C2909503537 @default.
• W1589803113 hasConceptScore W1589803113C548259974 @default.
• W1589803113 hasConceptScore W1589803113C71924100 @default.
• W1589803113 hasLocation W15898031131 @default.
• W1589803113 hasLocation W15898031132 @default.
• W1589803113 hasOpenAccess W1589803113 @default.
• W1589803113 hasPrimaryLocation W15898031131 @default.
• W1589803113 hasRelatedWork W1485230568 @default.
• W1589803113 hasRelatedWork W1992798574 @default.
• W1589803113 hasRelatedWork W2031743784 @default.
• W1589803113 hasRelatedWork W2032005995 @default.

• next