FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1589869891> ?p ?o ?g. }

• W1589869891 endingPage "490" @default.
• W1589869891 startingPage "480" @default.
• W1589869891 abstract "To facilitate antigenic characterization of the influenza A 2009 pandemic H1N1 [A(H1N1)pdm09] hemagglutinin (HA), we generated a panel of murine monoclonal antibodies (mAbs) using as the immunogen mammalian-derived virus-like particles containing the HA of the A/California/04/2009 virus. The antibodies were specific for the A/California/04/2009 HA, and individual mAbs suitable for use in several practical applications including ELISA, immunofluorescence, and Western blot analysis were identified.As the panel of mAbs included antibodies with hemagglutination inhibition (HI) and virus neutralizing activities, this allowed identification and characterization of potentially important antigenic and neutralizing epitopes of the A/California/04/2009 HA and comparison of those epitopes with the HAs of other influenza viruses including seasonal H1N1 viruses as well as the A/South Carolina/1918 and A/New Jersey/1976 H1N1 viruses. Three mAbs with the highest HI and neutralizing titers were able to provide passive protection against virus challenge. Two other mAbs without HI or neutralizing activities were able to provide partial protection against challenge. HA epitopes recognized by the strongest neutralizing mAbs in the panel were identified by isolation and selection of virus escape mutants in the presence of individual mAbs. Cloned viruses resistant to HI and antibody neutralization were sequenced to identify mutations, and two unique mutations (D127E and G155E) were identified, both near the antigenic site Sa. Using human post-vaccination sera, however, there were no differences in HI titer between A/California/04/2009 and either escape mutant, suggesting that these single mutations were not sufficient to abrogate a protective antibody response to the vaccine." @default.
• W1589869891 created "2016-06-24" @default.
• W1589869891 creator A5003112122 @default.
• W1589869891 creator A5037390063 @default.
• W1589869891 creator A5046597133 @default.
• W1589869891 creator A5050118443 @default.
• W1589869891 creator A5051602075 @default.
• W1589869891 creator A5060620716 @default.
• W1589869891 creator A5075101337 @default.
• W1589869891 creator A5075752021 @default.
• W1589869891 creator A5077240172 @default.
• W1589869891 creator A5084568061 @default.
• W1589869891 creator A5091349622 @default.
• W1589869891 date "2012-11-05" @default.
• W1589869891 modified "2023-10-13" @default.
• W1589869891 title "Neutralizing and protective epitopes of the 2009 pandemic influenza H1N1 hemagglutinin" @default.
• W1589869891 cites W1840458334 @default.
• W1589869891 cites W1927731993 @default.
• W1589869891 cites W1974428710 @default.
• W1589869891 cites W1987110746 @default.
• W1589869891 cites W2004477764 @default.
• W1589869891 cites W2005637605 @default.
• W1589869891 cites W2016665377 @default.
• W1589869891 cites W2017148875 @default.
• W1589869891 cites W2017532035 @default.
• W1589869891 cites W2026195872 @default.
• W1589869891 cites W2027992218 @default.
• W1589869891 cites W2032512723 @default.
• W1589869891 cites W2041700281 @default.
• W1589869891 cites W2041753380 @default.
• W1589869891 cites W2053295782 @default.
• W1589869891 cites W2061138316 @default.
• W1589869891 cites W2062740562 @default.
• W1589869891 cites W2065193241 @default.
• W1589869891 cites W2065959626 @default.
• W1589869891 cites W2068592034 @default.
• W1589869891 cites W2077900088 @default.
• W1589869891 cites W2090353509 @default.
• W1589869891 cites W2094406540 @default.
• W1589869891 cites W2103215633 @default.
• W1589869891 cites W2118852492 @default.
• W1589869891 cites W2121009566 @default.
• W1589869891 cites W2123599709 @default.
• W1589869891 cites W2124935992 @default.
• W1589869891 cites W2137834917 @default.
• W1589869891 cites W2144681905 @default.
• W1589869891 cites W2155467153 @default.
• W1589869891 cites W2157116486 @default.
• W1589869891 cites W2157507461 @default.
• W1589869891 cites W2165896641 @default.
• W1589869891 cites W2170295144 @default.
• W1589869891 cites W2172059715 @default.
• W1589869891 cites W2312463092 @default.
• W1589869891 doi "https://doi.org/10.1111/irv.12029" @default.
• W1589869891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5779835" @default.
• W1589869891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23122228" @default.
• W1589869891 hasPublicationYear "2012" @default.
• W1589869891 type Work @default.
• W1589869891 sameAs 1589869891 @default.
• W1589869891 citedByCount "17" @default.
• W1589869891 countsByYear W15898698912013 @default.
• W1589869891 countsByYear W15898698912014 @default.
• W1589869891 countsByYear W15898698912015 @default.
• W1589869891 countsByYear W15898698912016 @default.
• W1589869891 countsByYear W15898698912017 @default.
• W1589869891 countsByYear W15898698912018 @default.
• W1589869891 countsByYear W15898698912022 @default.
• W1589869891 countsByYear W15898698912023 @default.
• W1589869891 crossrefType "journal-article" @default.
• W1589869891 hasAuthorship W1589869891A5003112122 @default.
• W1589869891 hasAuthorship W1589869891A5037390063 @default.
• W1589869891 hasAuthorship W1589869891A5046597133 @default.
• W1589869891 hasAuthorship W1589869891A5050118443 @default.
• W1589869891 hasAuthorship W1589869891A5051602075 @default.
• W1589869891 hasAuthorship W1589869891A5060620716 @default.
• W1589869891 hasAuthorship W1589869891A5075101337 @default.
• W1589869891 hasAuthorship W1589869891A5075752021 @default.
• W1589869891 hasAuthorship W1589869891A5077240172 @default.
• W1589869891 hasAuthorship W1589869891A5084568061 @default.
• W1589869891 hasAuthorship W1589869891A5091349622 @default.
• W1589869891 hasBestOaLocation W15898698912 @default.
• W1589869891 hasConcept C14086860 @default.
• W1589869891 hasConcept C142724271 @default.
• W1589869891 hasConcept C147483822 @default.
• W1589869891 hasConcept C159047783 @default.
• W1589869891 hasConcept C159654299 @default.
• W1589869891 hasConcept C195616568 @default.
• W1589869891 hasConcept C203014093 @default.
• W1589869891 hasConcept C2522874641 @default.
• W1589869891 hasConcept C2777546802 @default.
• W1589869891 hasConcept C2778692840 @default.
• W1589869891 hasConcept C2779134260 @default.
• W1589869891 hasConcept C2779261636 @default.
• W1589869891 hasConcept C2779909307 @default.
• W1589869891 hasConcept C3008058167 @default.
• W1589869891 hasConcept C32611913 @default.
• W1589869891 hasConcept C524204448 @default.
• W1589869891 hasConcept C542903549 @default.

• next