Matches in SemOpenAlex for { <https://semopenalex.org/work/W1590089681> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1590089681 endingPage "15244" @default.
- W1590089681 startingPage "15241" @default.
- W1590089681 abstract "Sphingosine is a potent inhibitor of several calmodulin-dependent enzymes. The multifunctional Ca2+/calmodulin-dependent protein kinase, a Ca2+/calmodulin-dependent phosphodiesterase, and smooth muscle myosin light chain kinase are inhibited in vitro at concentrations previously shown to inhibit protein kinase C. Inhibition of each of the enzymes is competitive with calmodulin, suggesting that sphingosine may be a calmodulin antagonist. In the pituitary cell line GH3, sphingosine inhibits the phosphorylation of microtubule-associated protein 2 by the multifunctional Ca2+/calmodulin-dependent protein kinase and the phosphorylation of elongation factor 2 by Ca2+/calmodulin-dependent kinase III. These findings suggest that sphingosine, in blocking the effects of both the Ca2+.calmodulin complex and of diacylglycerol, may be a very effective inhibitor of both branches of the phosphatidylinositol signaling pathway. By extension, caution should be exercised in the use of sphingosine as a diagnostic test for the involvement of protein kinase C in biological processes." @default.
- W1590089681 created "2016-06-24" @default.
- W1590089681 creator A5044213465 @default.
- W1590089681 creator A5058557647 @default.
- W1590089681 date "1988-10-01" @default.
- W1590089681 modified "2023-10-18" @default.
- W1590089681 title "Sphingosine inhibits calmodulin-dependent enzymes." @default.
- W1590089681 cites W1479774456 @default.
- W1590089681 cites W1524495054 @default.
- W1590089681 cites W1534428859 @default.
- W1590089681 cites W1555606052 @default.
- W1590089681 cites W1561270065 @default.
- W1590089681 cites W1583656960 @default.
- W1590089681 cites W1590908262 @default.
- W1590089681 cites W1595133660 @default.
- W1590089681 cites W1598451699 @default.
- W1590089681 cites W1602448176 @default.
- W1590089681 cites W1661233179 @default.
- W1590089681 cites W1763105928 @default.
- W1590089681 cites W1860351953 @default.
- W1590089681 cites W1874231349 @default.
- W1590089681 cites W1964839077 @default.
- W1590089681 cites W1970666320 @default.
- W1590089681 cites W1988245688 @default.
- W1590089681 cites W1992170822 @default.
- W1590089681 cites W1992472345 @default.
- W1590089681 cites W2002351613 @default.
- W1590089681 cites W2044381533 @default.
- W1590089681 cites W2081330336 @default.
- W1590089681 cites W2095526331 @default.
- W1590089681 cites W2122503622 @default.
- W1590089681 cites W2159913935 @default.
- W1590089681 cites W988325438 @default.
- W1590089681 cites W990604247 @default.
- W1590089681 doi "https://doi.org/10.1016/s0021-9258(19)37576-3" @default.
- W1590089681 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2844804" @default.
- W1590089681 hasPublicationYear "1988" @default.
- W1590089681 type Work @default.
- W1590089681 sameAs 1590089681 @default.
- W1590089681 citedByCount "209" @default.
- W1590089681 countsByYear W15900896812013 @default.
- W1590089681 countsByYear W15900896812015 @default.
- W1590089681 countsByYear W15900896812017 @default.
- W1590089681 countsByYear W15900896812018 @default.
- W1590089681 countsByYear W15900896812019 @default.
- W1590089681 crossrefType "journal-article" @default.
- W1590089681 hasAuthorship W1590089681A5044213465 @default.
- W1590089681 hasAuthorship W1590089681A5058557647 @default.
- W1590089681 hasBestOaLocation W15900896811 @default.
- W1590089681 hasConcept C12554922 @default.
- W1590089681 hasConcept C170493617 @default.
- W1590089681 hasConcept C181199279 @default.
- W1590089681 hasConcept C185592680 @default.
- W1590089681 hasConcept C2778703144 @default.
- W1590089681 hasConcept C29688787 @default.
- W1590089681 hasConcept C55493867 @default.
- W1590089681 hasConcept C86803240 @default.
- W1590089681 hasConcept C95444343 @default.
- W1590089681 hasConceptScore W1590089681C12554922 @default.
- W1590089681 hasConceptScore W1590089681C170493617 @default.
- W1590089681 hasConceptScore W1590089681C181199279 @default.
- W1590089681 hasConceptScore W1590089681C185592680 @default.
- W1590089681 hasConceptScore W1590089681C2778703144 @default.
- W1590089681 hasConceptScore W1590089681C29688787 @default.
- W1590089681 hasConceptScore W1590089681C55493867 @default.
- W1590089681 hasConceptScore W1590089681C86803240 @default.
- W1590089681 hasConceptScore W1590089681C95444343 @default.
- W1590089681 hasIssue "30" @default.
- W1590089681 hasLocation W15900896811 @default.
- W1590089681 hasOpenAccess W1590089681 @default.
- W1590089681 hasPrimaryLocation W15900896811 @default.
- W1590089681 hasRelatedWork W1972645610 @default.
- W1590089681 hasRelatedWork W1977447152 @default.
- W1590089681 hasRelatedWork W2024235420 @default.
- W1590089681 hasRelatedWork W2055841700 @default.
- W1590089681 hasRelatedWork W2069013852 @default.
- W1590089681 hasRelatedWork W2086803471 @default.
- W1590089681 hasRelatedWork W2390452488 @default.
- W1590089681 hasRelatedWork W2416011990 @default.
- W1590089681 hasRelatedWork W939296483 @default.
- W1590089681 hasRelatedWork W949903301 @default.
- W1590089681 hasVolume "263" @default.
- W1590089681 isParatext "false" @default.
- W1590089681 isRetracted "false" @default.
- W1590089681 magId "1590089681" @default.
- W1590089681 workType "article" @default.