FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1590162275> ?p ?o ?g. }

• W1590162275 endingPage "2783" @default.
• W1590162275 startingPage "2772" @default.
• W1590162275 abstract "NFAT plays a crucial role in the immune system by regulating the transcription of inducible genes during immune responses. In T cells, NFAT proteins govern various cellular events related to T cell development, activation, tolerance induction, and differentiation. We previously reported the NFAT1-dependent enhancer activity of conserved noncoding sequence (CNS)-9, a distal cis-acting element, in the regulation of IL-10 transcription in T cells. In this study, we developed a T cell-based reporter system to identify compounds that modulate the regulatory activity of CNS-9. Among the identified candidates, 6-methoxyflavone (6-MF) significantly inhibited the enhancer activity of CNS-9, thereby reducing IL-10 expression in T cells without affecting cell viability. 6-MF also downregulated the transcription of NFAT1 target genes such as IL-4, IL-13, and IFN-γ. Treatment of 6-MF inhibited the translocation of NFAT1 into the nucleus, which consequently interrupted NFAT1 binding to the target loci, without affecting the expression or dephosphorylation of NFAT1. Treatment of 6-MF to CD4(+) T cells or B cells isolated from mice with atopic dermatitis significantly reduced disease-associated cytokine production, as well as the levels of IgE. In addition, oral administration of 6-MF to atopic dermatitis mice ameliorated disease symptoms by reducing serum IgE levels and infiltrating lymphocytes. Conclusively, our results suggest that 6-MF can be a potential candidate for the development of an effective immunomodulator via the suppression of NFAT-mediated T cell activation." @default.
• W1590162275 created "2016-06-24" @default.
• W1590162275 creator A5011361600 @default.
• W1590162275 creator A5018682015 @default.
• W1590162275 creator A5023173703 @default.
• W1590162275 creator A5028669492 @default.
• W1590162275 creator A5034182950 @default.
• W1590162275 creator A5041592062 @default.
• W1590162275 creator A5051067133 @default.
• W1590162275 creator A5052901510 @default.
• W1590162275 creator A5088882690 @default.
• W1590162275 date "2014-09-15" @default.
• W1590162275 modified "2023-10-05" @default.
• W1590162275 title "6-Methoxyflavone Inhibits NFAT Translocation into the Nucleus and Suppresses T Cell Activation" @default.
• W1590162275 cites W1624803461 @default.
• W1590162275 cites W1847275787 @default.
• W1590162275 cites W1969971113 @default.
• W1590162275 cites W1976260744 @default.
• W1590162275 cites W1977122148 @default.
• W1590162275 cites W1981859401 @default.
• W1590162275 cites W1983612298 @default.
• W1590162275 cites W1983905203 @default.
• W1590162275 cites W1985677612 @default.
• W1590162275 cites W1987676683 @default.
• W1590162275 cites W1990979855 @default.
• W1590162275 cites W1991195369 @default.
• W1590162275 cites W1993923229 @default.
• W1590162275 cites W1997430037 @default.
• W1590162275 cites W1999931163 @default.
• W1590162275 cites W2016642606 @default.
• W1590162275 cites W2017104717 @default.
• W1590162275 cites W2019648640 @default.
• W1590162275 cites W2026087264 @default.
• W1590162275 cites W2026389046 @default.
• W1590162275 cites W2028211858 @default.
• W1590162275 cites W2048544857 @default.
• W1590162275 cites W2048695976 @default.
• W1590162275 cites W2055803387 @default.
• W1590162275 cites W2059412719 @default.
• W1590162275 cites W2061851471 @default.
• W1590162275 cites W2064811354 @default.
• W1590162275 cites W2066603202 @default.
• W1590162275 cites W2070407991 @default.
• W1590162275 cites W2071709931 @default.
• W1590162275 cites W2073229191 @default.
• W1590162275 cites W2073580835 @default.
• W1590162275 cites W2076956056 @default.
• W1590162275 cites W2089933783 @default.
• W1590162275 cites W2089988801 @default.
• W1590162275 cites W2090449508 @default.
• W1590162275 cites W2108213612 @default.
• W1590162275 cites W2113470262 @default.
• W1590162275 cites W2116060738 @default.
• W1590162275 cites W2123298166 @default.
• W1590162275 cites W2137551688 @default.
• W1590162275 cites W2140707292 @default.
• W1590162275 cites W2143522905 @default.
• W1590162275 cites W2145676965 @default.
• W1590162275 cites W2157973267 @default.
• W1590162275 cites W2162201817 @default.
• W1590162275 cites W2171968926 @default.
• W1590162275 doi "https://doi.org/10.4049/jimmunol.1400285" @default.
• W1590162275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25114106" @default.
• W1590162275 hasPublicationYear "2014" @default.
• W1590162275 type Work @default.
• W1590162275 sameAs 1590162275 @default.
• W1590162275 citedByCount "8" @default.
• W1590162275 countsByYear W15901622752017 @default.
• W1590162275 countsByYear W15901622752021 @default.
• W1590162275 countsByYear W15901622752022 @default.
• W1590162275 crossrefType "journal-article" @default.
• W1590162275 hasAuthorship W1590162275A5011361600 @default.
• W1590162275 hasAuthorship W1590162275A5018682015 @default.
• W1590162275 hasAuthorship W1590162275A5023173703 @default.
• W1590162275 hasAuthorship W1590162275A5028669492 @default.
• W1590162275 hasAuthorship W1590162275A5034182950 @default.
• W1590162275 hasAuthorship W1590162275A5041592062 @default.
• W1590162275 hasAuthorship W1590162275A5051067133 @default.
• W1590162275 hasAuthorship W1590162275A5052901510 @default.
• W1590162275 hasAuthorship W1590162275A5088882690 @default.
• W1590162275 hasBestOaLocation W15901622751 @default.
• W1590162275 hasConcept C104317684 @default.
• W1590162275 hasConcept C111936080 @default.
• W1590162275 hasConcept C150194340 @default.
• W1590162275 hasConcept C153911025 @default.
• W1590162275 hasConcept C161733203 @default.
• W1590162275 hasConcept C185592680 @default.
• W1590162275 hasConcept C189938988 @default.
• W1590162275 hasConcept C203014093 @default.
• W1590162275 hasConcept C2776090121 @default.
• W1590162275 hasConcept C2778329239 @default.
• W1590162275 hasConcept C55493867 @default.
• W1590162275 hasConcept C86339819 @default.
• W1590162275 hasConcept C86803240 @default.
• W1590162275 hasConcept C8891405 @default.
• W1590162275 hasConcept C95444343 @default.
• W1590162275 hasConceptScore W1590162275C104317684 @default.
• W1590162275 hasConceptScore W1590162275C111936080 @default.

• next