FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1590261010> ?p ?o ?g. }

• W1590261010 endingPage "268" @default.
• W1590261010 startingPage "262" @default.
• W1590261010 abstract "PARP inhibitors are considered promising anticancer agents and currently being tested in clinical trials in hereditary breast cancer patients harboring mutations in BRCA1 and BRCA2 genes. In this study, we investigated the antiproliferative effects and mechanism of PARP inhibitors ABT-888 (Veliparib), BSI-201 (Iniparib) and AZD228 (Olaparib) in breast cancer cell lines with BRCA1 or BRCA2 mutations and 9 different BRCA wild-type cell lines with BRCA1 allelic loss. We found that AZD2281 was the most potent in the PARP inhibitors and induces significant growth inhibition (~95%) in BRCA1 mutant (HCC‑1937, MDA-MB-436, and SUM-149PT) and BRCA2 mutant (HCC‑1428) cell lines. AZD2281 treatment also resulted in growth inhibition ranging from 20 to 50% in cells with BRCA1 allelic loss, including ER(+), HER2/Neu(+) and triple-negative breast cancer (TNBC) cells, but showed no effect in cells without with type BRCA without allelic loss. Knocking down of BRCA1 or BRCA2 in TNBC cells with BRCA1 allelic loss by RNA interference significantly enhanced AZD2281-induced growth inhibition and induced significant autophagy that was associated with mitophagy in cells with BRCA mutations. Inhibition of autophagy by gene knockdown significantly diminished AZD2281-induced mitophagy and apoptosis, indicating that autophagic process mediates some of the downstream effects of PARP inhibitors. In conclusion, our data provide the first evidence of PARP inhibitor AZD2281 autophagy and mitophagy in breast cancer cell lines with BRCA mutations or BRCA-allelic loss. In addition, our results indicate that the patients with BRCA1 allelic loss may also benefit from PARP inhibitor therapy if BRCA is further inhibited." @default.
• W1590261010 created "2016-06-24" @default.
• W1590261010 creator A5005148722 @default.
• W1590261010 creator A5015127974 @default.
• W1590261010 creator A5018617106 @default.
• W1590261010 creator A5040193650 @default.
• W1590261010 creator A5090831288 @default.
• W1590261010 date "2015-05-12" @default.
• W1590261010 modified "2023-10-17" @default.
• W1590261010 title "The PARP inhibitor AZD2281 (Olaparib) induces autophagy/mitophagy in BRCA1 and BRCA2 mutant breast cancer cells" @default.
• W1590261010 cites W1489499258 @default.
• W1590261010 cites W1523693806 @default.
• W1590261010 cites W156316974 @default.
• W1590261010 cites W1969346276 @default.
• W1590261010 cites W1972769310 @default.
• W1590261010 cites W1973268287 @default.
• W1590261010 cites W1975676036 @default.
• W1590261010 cites W1975915706 @default.
• W1590261010 cites W1981191944 @default.
• W1590261010 cites W1995577291 @default.
• W1590261010 cites W2002962154 @default.
• W1590261010 cites W2009007206 @default.
• W1590261010 cites W2014599726 @default.
• W1590261010 cites W2020830322 @default.
• W1590261010 cites W2039167351 @default.
• W1590261010 cites W2048030072 @default.
• W1590261010 cites W2049016912 @default.
• W1590261010 cites W2052289985 @default.
• W1590261010 cites W2059365987 @default.
• W1590261010 cites W2059763709 @default.
• W1590261010 cites W2074446011 @default.
• W1590261010 cites W2074489279 @default.
• W1590261010 cites W2077397852 @default.
• W1590261010 cites W2098737737 @default.
• W1590261010 cites W2108484737 @default.
• W1590261010 cites W2109034822 @default.
• W1590261010 cites W2110017381 @default.
• W1590261010 cites W2124331048 @default.
• W1590261010 cites W2132734902 @default.
• W1590261010 cites W2135953007 @default.
• W1590261010 cites W2142491513 @default.
• W1590261010 cites W2171972386 @default.
• W1590261010 cites W3093265161 @default.
• W1590261010 doi "https://doi.org/10.3892/ijo.2015.3003" @default.
• W1590261010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6904111" @default.
• W1590261010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25975349" @default.
• W1590261010 hasPublicationYear "2015" @default.
• W1590261010 type Work @default.
• W1590261010 sameAs 1590261010 @default.
• W1590261010 citedByCount "73" @default.
• W1590261010 countsByYear W15902610102015 @default.
• W1590261010 countsByYear W15902610102016 @default.
• W1590261010 countsByYear W15902610102017 @default.
• W1590261010 countsByYear W15902610102018 @default.
• W1590261010 countsByYear W15902610102019 @default.
• W1590261010 countsByYear W15902610102020 @default.
• W1590261010 countsByYear W15902610102021 @default.
• W1590261010 countsByYear W15902610102022 @default.
• W1590261010 countsByYear W15902610102023 @default.
• W1590261010 crossrefType "journal-article" @default.
• W1590261010 hasAuthorship W1590261010A5005148722 @default.
• W1590261010 hasAuthorship W1590261010A5015127974 @default.
• W1590261010 hasAuthorship W1590261010A5018617106 @default.
• W1590261010 hasAuthorship W1590261010A5040193650 @default.
• W1590261010 hasAuthorship W1590261010A5090831288 @default.
• W1590261010 hasBestOaLocation W15902610101 @default.
• W1590261010 hasConcept C104317684 @default.
• W1590261010 hasConcept C121608353 @default.
• W1590261010 hasConcept C143065580 @default.
• W1590261010 hasConcept C173396325 @default.
• W1590261010 hasConcept C182979987 @default.
• W1590261010 hasConcept C190283241 @default.
• W1590261010 hasConcept C203522944 @default.
• W1590261010 hasConcept C2778502085 @default.
• W1590261010 hasConcept C2779138821 @default.
• W1590261010 hasConcept C2779324830 @default.
• W1590261010 hasConcept C2779962180 @default.
• W1590261010 hasConcept C2780110267 @default.
• W1590261010 hasConcept C502942594 @default.
• W1590261010 hasConcept C530470458 @default.
• W1590261010 hasConcept C54355233 @default.
• W1590261010 hasConcept C82381507 @default.
• W1590261010 hasConcept C86803240 @default.
• W1590261010 hasConceptScore W1590261010C104317684 @default.
• W1590261010 hasConceptScore W1590261010C121608353 @default.
• W1590261010 hasConceptScore W1590261010C143065580 @default.
• W1590261010 hasConceptScore W1590261010C173396325 @default.
• W1590261010 hasConceptScore W1590261010C182979987 @default.
• W1590261010 hasConceptScore W1590261010C190283241 @default.
• W1590261010 hasConceptScore W1590261010C203522944 @default.
• W1590261010 hasConceptScore W1590261010C2778502085 @default.
• W1590261010 hasConceptScore W1590261010C2779138821 @default.
• W1590261010 hasConceptScore W1590261010C2779324830 @default.
• W1590261010 hasConceptScore W1590261010C2779962180 @default.
• W1590261010 hasConceptScore W1590261010C2780110267 @default.
• W1590261010 hasConceptScore W1590261010C502942594 @default.
• W1590261010 hasConceptScore W1590261010C530470458 @default.
• W1590261010 hasConceptScore W1590261010C54355233 @default.

• next