FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1590367571> ?p ?o ?g. }

• W1590367571 endingPage "6633" @default.
• W1590367571 startingPage "6625" @default.
• W1590367571 abstract "Rheumatoid arthritis is characterized by synovial joint infiltration of activated CD4(+) T cells and MHC class II(+) APC, and is linked to specific HLA-DR alleles. Candidate autoantigens in synovial fluid and cartilage include type II collagen (CII) and cartilage gp39 (HCgp39). Using preparations of native Ag and T cells derived from Ag-immunized DR4-transgenic mice, we determined that human ex vivo differentiated DR4(+) dendritic cells (DC) and macrophages (Mphi) can mediate MHC class II presentation of CII or HCgp39 epitopes. The form of the Ag (soluble, partially degraded, or particulate) delivered to the APC influenced its presentation by DC and Mphi. DC efficiently presented partially degraded, but not native CII alpha-chains, while Mphi presentation was most efficient after phagocytosis of bead-conjugated CII. Both DC and Mphi presented soluble HCgp39, and activated Mphi from some donors presented epitopes derived from endogenously synthesized HCgp39. When synovial fluid from rheumatoid arthritis patients was used as a source of Ag, DC presentation of HCgp39 and CII epitopes was efficient, indicating that synovial fluid contains soluble forms of CII and HCgp39 amenable to internalization, processing, and presentation. These data support the hypothesis that CII and HCgp39 are autoantigens and that their class II-mediated presentation by DC and Mphi to T cells in vivo has a critical role in the pathogenesis of human rheumatoid arthritis." @default.
• W1590367571 created "2016-06-24" @default.
• W1590367571 creator A5012051319 @default.
• W1590367571 creator A5038454601 @default.
• W1590367571 creator A5046597133 @default.
• W1590367571 creator A5062163702 @default.
• W1590367571 creator A5073858223 @default.
• W1590367571 creator A5078914293 @default.
• W1590367571 date "2002-12-01" @default.
• W1590367571 modified "2023-09-25" @default.
• W1590367571 title "Differential MHC Class II-Mediated Presentation of Rheumatoid Arthritis Autoantigens by Human Dendritic Cells and Macrophages" @default.
• W1590367571 cites W1485202890 @default.
• W1590367571 cites W1509790685 @default.
• W1590367571 cites W1515725948 @default.
• W1590367571 cites W1561376808 @default.
• W1590367571 cites W1568609804 @default.
• W1590367571 cites W1570193556 @default.
• W1590367571 cites W1661243937 @default.
• W1590367571 cites W1835297465 @default.
• W1590367571 cites W1900312847 @default.
• W1590367571 cites W1941240823 @default.
• W1590367571 cites W1967868917 @default.
• W1590367571 cites W1993975028 @default.
• W1590367571 cites W1997027978 @default.
• W1590367571 cites W1997708871 @default.
• W1590367571 cites W1998098073 @default.
• W1590367571 cites W2011541044 @default.
• W1590367571 cites W2023691634 @default.
• W1590367571 cites W2024285859 @default.
• W1590367571 cites W2025374520 @default.
• W1590367571 cites W2036048466 @default.
• W1590367571 cites W2038292888 @default.
• W1590367571 cites W2048813988 @default.
• W1590367571 cites W2049079346 @default.
• W1590367571 cites W2058365984 @default.
• W1590367571 cites W2064523705 @default.
• W1590367571 cites W2069978881 @default.
• W1590367571 cites W2087193732 @default.
• W1590367571 cites W2097833923 @default.
• W1590367571 cites W2100571347 @default.
• W1590367571 cites W2103819978 @default.
• W1590367571 cites W2111695773 @default.
• W1590367571 cites W2113360996 @default.
• W1590367571 cites W2115659318 @default.
• W1590367571 cites W2119261483 @default.
• W1590367571 cites W2123333870 @default.
• W1590367571 cites W2131761283 @default.
• W1590367571 cites W2140985128 @default.
• W1590367571 cites W2144582765 @default.
• W1590367571 cites W2146045246 @default.
• W1590367571 cites W2148191159 @default.
• W1590367571 cites W2149162014 @default.
• W1590367571 cites W2152348310 @default.
• W1590367571 cites W2161178631 @default.
• W1590367571 cites W2163660675 @default.
• W1590367571 cites W2170983988 @default.
• W1590367571 cites W4236183098 @default.
• W1590367571 cites W4237442934 @default.
• W1590367571 cites W66527107 @default.
• W1590367571 doi "https://doi.org/10.4049/jimmunol.169.11.6625" @default.
• W1590367571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12444176" @default.
• W1590367571 hasPublicationYear "2002" @default.
• W1590367571 type Work @default.
• W1590367571 sameAs 1590367571 @default.
• W1590367571 citedByCount "82" @default.
• W1590367571 countsByYear W15903675712012 @default.
• W1590367571 countsByYear W15903675712013 @default.
• W1590367571 countsByYear W15903675712014 @default.
• W1590367571 countsByYear W15903675712015 @default.
• W1590367571 countsByYear W15903675712016 @default.
• W1590367571 countsByYear W15903675712017 @default.
• W1590367571 countsByYear W15903675712019 @default.
• W1590367571 countsByYear W15903675712020 @default.
• W1590367571 countsByYear W15903675712021 @default.
• W1590367571 countsByYear W15903675712022 @default.
• W1590367571 countsByYear W15903675712023 @default.
• W1590367571 crossrefType "journal-article" @default.
• W1590367571 hasAuthorship W1590367571A5012051319 @default.
• W1590367571 hasAuthorship W1590367571A5038454601 @default.
• W1590367571 hasAuthorship W1590367571A5046597133 @default.
• W1590367571 hasAuthorship W1590367571A5062163702 @default.
• W1590367571 hasAuthorship W1590367571A5073858223 @default.
• W1590367571 hasAuthorship W1590367571A5078914293 @default.
• W1590367571 hasBestOaLocation W15903675711 @default.
• W1590367571 hasConcept C108249834 @default.
• W1590367571 hasConcept C142724271 @default.
• W1590367571 hasConcept C147483822 @default.
• W1590367571 hasConcept C150903083 @default.
• W1590367571 hasConcept C167672396 @default.
• W1590367571 hasConcept C170627219 @default.
• W1590367571 hasConcept C185592680 @default.
• W1590367571 hasConcept C195616568 @default.
• W1590367571 hasConcept C203014093 @default.
• W1590367571 hasConcept C204787440 @default.
• W1590367571 hasConcept C207001950 @default.
• W1590367571 hasConcept C207936829 @default.
• W1590367571 hasConcept C26291073 @default.
• W1590367571 hasConcept C2776090121 @default.

• next