FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1590429307> ?p ?o ?g. }

• W1590429307 endingPage "e255" @default.
• W1590429307 startingPage "560" @default.
• W1590429307 abstract "Background The role of serotonin transporter (SERT) gene polymorphism in irritable bowel syndrome (IBS) has been demonstrated. However, the expression of SERT mRNA and proteins in the colonic mucosa with different 5-HTT gene-linked polymorphic region (5-HTTLPR) genotypes remains unknown. We examined SERT mRNA and protein levels in colon biopsies from patients with different 5-HTTLPR genotypes and evaluated the links between the polymorphism and the expression levels. Methods Two hundred and fifty-four patients with IBS and 120 healthy subjects were studied. DNA samples were extracted from peripheral blood and genotyped by polymerase chain reaction (PCR). SERT mRNA and protein levels were evaluated by quantitative real time PCR and western blotting. The promoter efficiency of the serotonin transporter promoter (SERT-P) was evaluated with luciferase reporter system. Key Results The frequency of the L/L genotype in C-IBS group was significantly higher than that in the control and D-IBS. However, the S/S genotype in D-IBS was significantly higher than that in C-IBS. The transcriptional efficiency of the L/L genotype was significantly higher than that in the L/S and S/S genotype. Patients with the L/L genotype demonstrated increased production of the SERT protein when compared with L/S and S/S patients. The l variant increased SERT promoter activity by 2.43-fold when compared with the s variant. Conclusions & Inferences Polymorphism in the promoter region of the SERT gene can influence the expression of SERT mRNA and the levels of the SERT protein in the colonic mucosa, thereby playing a key role in motility-related symptoms of IBS patients." @default.
• W1590429307 created "2016-06-24" @default.
• W1590429307 creator A5007810274 @default.
• W1590429307 creator A5008750627 @default.
• W1590429307 creator A5010455134 @default.
• W1590429307 creator A5010913114 @default.
• W1590429307 creator A5014842511 @default.
• W1590429307 creator A5015110667 @default.
• W1590429307 creator A5021727546 @default.
• W1590429307 creator A5032336441 @default.
• W1590429307 creator A5043111221 @default.
• W1590429307 date "2012-03-21" @default.
• W1590429307 modified "2023-10-09" @default.
• W1590429307 title "Serotonin transporter gene promoter region polymorphisms and serotonin transporter expression in the colonic mucosa of irritable bowel syndrome patients" @default.
• W1590429307 cites W1545792411 @default.
• W1590429307 cites W1583019213 @default.
• W1590429307 cites W1962934739 @default.
• W1590429307 cites W1967579346 @default.
• W1590429307 cites W1969144895 @default.
• W1590429307 cites W1974356299 @default.
• W1590429307 cites W1982955132 @default.
• W1590429307 cites W1984181078 @default.
• W1590429307 cites W1988694820 @default.
• W1590429307 cites W1992033675 @default.
• W1590429307 cites W1993725963 @default.
• W1590429307 cites W1998351388 @default.
• W1590429307 cites W1998378561 @default.
• W1590429307 cites W1999194156 @default.
• W1590429307 cites W2000587317 @default.
• W1590429307 cites W2005534453 @default.
• W1590429307 cites W2009595947 @default.
• W1590429307 cites W2021290527 @default.
• W1590429307 cites W2033835666 @default.
• W1590429307 cites W2058976148 @default.
• W1590429307 cites W2061555673 @default.
• W1590429307 cites W2070872078 @default.
• W1590429307 cites W2070931231 @default.
• W1590429307 cites W2071694198 @default.
• W1590429307 cites W2092953813 @default.
• W1590429307 cites W2097566770 @default.
• W1590429307 cites W2106095564 @default.
• W1590429307 cites W2109016050 @default.
• W1590429307 cites W2122965264 @default.
• W1590429307 cites W2124947778 @default.
• W1590429307 cites W2127983504 @default.
• W1590429307 cites W2156286274 @default.
• W1590429307 cites W2156980099 @default.
• W1590429307 cites W2162140723 @default.
• W1590429307 doi "https://doi.org/10.1111/j.1365-2982.2012.01902.x" @default.
• W1590429307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22435794" @default.
• W1590429307 hasPublicationYear "2012" @default.
• W1590429307 type Work @default.
• W1590429307 sameAs 1590429307 @default.
• W1590429307 citedByCount "37" @default.
• W1590429307 countsByYear W15904293072013 @default.
• W1590429307 countsByYear W15904293072014 @default.
• W1590429307 countsByYear W15904293072015 @default.
• W1590429307 countsByYear W15904293072016 @default.
• W1590429307 countsByYear W15904293072017 @default.
• W1590429307 countsByYear W15904293072018 @default.
• W1590429307 countsByYear W15904293072019 @default.
• W1590429307 countsByYear W15904293072021 @default.
• W1590429307 countsByYear W15904293072022 @default.
• W1590429307 crossrefType "journal-article" @default.
• W1590429307 hasAuthorship W1590429307A5007810274 @default.
• W1590429307 hasAuthorship W1590429307A5008750627 @default.
• W1590429307 hasAuthorship W1590429307A5010455134 @default.
• W1590429307 hasAuthorship W1590429307A5010913114 @default.
• W1590429307 hasAuthorship W1590429307A5014842511 @default.
• W1590429307 hasAuthorship W1590429307A5015110667 @default.
• W1590429307 hasAuthorship W1590429307A5021727546 @default.
• W1590429307 hasAuthorship W1590429307A5032336441 @default.
• W1590429307 hasAuthorship W1590429307A5043111221 @default.
• W1590429307 hasConcept C101762097 @default.
• W1590429307 hasConcept C104317684 @default.
• W1590429307 hasConcept C105580179 @default.
• W1590429307 hasConcept C126322002 @default.
• W1590429307 hasConcept C134018914 @default.
• W1590429307 hasConcept C135763542 @default.
• W1590429307 hasConcept C149737253 @default.
• W1590429307 hasConcept C150194340 @default.
• W1590429307 hasConcept C153911025 @default.
• W1590429307 hasConcept C170493617 @default.
• W1590429307 hasConcept C2775864247 @default.
• W1590429307 hasConcept C2778271842 @default.
• W1590429307 hasConcept C2778897192 @default.
• W1590429307 hasConcept C2908747647 @default.
• W1590429307 hasConcept C54355233 @default.
• W1590429307 hasConcept C71924100 @default.
• W1590429307 hasConcept C86803240 @default.
• W1590429307 hasConceptScore W1590429307C101762097 @default.
• W1590429307 hasConceptScore W1590429307C104317684 @default.
• W1590429307 hasConceptScore W1590429307C105580179 @default.
• W1590429307 hasConceptScore W1590429307C126322002 @default.
• W1590429307 hasConceptScore W1590429307C134018914 @default.
• W1590429307 hasConceptScore W1590429307C135763542 @default.
• W1590429307 hasConceptScore W1590429307C149737253 @default.
• W1590429307 hasConceptScore W1590429307C150194340 @default.

• next