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• W1590433357 abstract "Rates and risk factors for acquired drug resistance and association with outcomes among patients with multidrug-resistant tuberculosis (MDR TB) are not well defined. In an MDR TB cohort from the country of Georgia, drug susceptibility testing for second-line drugs (SLDs) was performed at baseline and every third month. Acquired resistance was defined as any SLD whose status changed from susceptible at baseline to resistant at follow-up. Among 141 patients, acquired resistance in Mycobacterium tuberculosis was observed in 19 (14%); prevalence was 9.1% for ofloxacin and 9.8% for capreomycin or kanamycin. Baseline cavitary disease and resistance to >6 drugs were associated with acquired resistance. Patients with M. tuberculosis that had acquired resistance were at significantly increased risk for poor treatment outcome compared with patients without these isolates (89% vs. 36%; p<0.01). Acquired resistance occurs commonly among patients with MDR TB and impedes successful treatment outcomes." @default.
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• W1590433357 date "2015-06-01" @default.
• W1590433357 modified "2023-09-25" @default.
• W1590433357 title "Acquired Drug Resistance in<i>Mycobacterium tuberculosis</i>and Poor Outcomes among Patients with Multidrug-Resistant Tuberculosis" @default.
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• W1590433357 doi "https://doi.org/10.3201/eid2106.141873" @default.
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