Matches in SemOpenAlex for { <https://semopenalex.org/work/W1590444888> ?p ?o ?g. }
- W1590444888 endingPage "492" @default.
- W1590444888 startingPage "469" @default.
- W1590444888 abstract "Abstract Nanotechnology involves manipulating matter at the nanoscale (<1000 nm); that is, manipulations at less than thousandth of a millimeter, and for drug delivery applications this typically takes the form of creating nanoparticles (5 ∼ 800 nm) that are then used to package drug molecules and genes. By packaging pharmacologically active compounds within nanoparticles, nanomedicines are created. It is possible to control drug biodistribution and achieve therapeutic benefit with these nanomedicines. This chapter outlines the various chemistries and nanomedicine preparation strategies that have been used to produce nanoparticles and highlights the drug delivery benefits that are achievable from these nanoscale arrangements. The chemical compounds used to construct these nanomedicines are as follows: low molecular weight self‐assembling amphiphiles, self‐assembling amphiphilic polymers, polymer–drug conjugates, water insoluble polymers/cross‐linked polymers, dendrimers, and carbon nanotubes. Engineering of these particles has produced nanomedicines that target drugs and genes to tumors and improve the brain delivery of peptides and other molecules. These particles are also capable of promoting oral drug absorption and drug transport across other biological barriers such as the cornea and the skin. Only a few of these technologies are commercially available presently, such as liposomes (e.g., Doxil®), low molecular weight micelles (e.g., Fungizone®), and polymer–drug conjugates (Oncaspar®); but the therapeutic benefits being observed in both preclinical studies and early clinical testing suggest that more of these technologies will emerge into the patient arena in the future." @default.
- W1590444888 created "2016-06-24" @default.
- W1590444888 creator A5024593530 @default.
- W1590444888 creator A5037398789 @default.
- W1590444888 date "2010-09-15" @default.
- W1590444888 modified "2023-10-04" @default.
- W1590444888 title "Nanotechnology in Drug Delivery" @default.
- W1590444888 cites W108016466 @default.
- W1590444888 cites W1221966150 @default.
- W1590444888 cites W1483781798 @default.
- W1590444888 cites W1499573758 @default.
- W1590444888 cites W1526328115 @default.
- W1590444888 cites W1543763253 @default.
- W1590444888 cites W1553061387 @default.
- W1590444888 cites W1583373908 @default.
- W1590444888 cites W1599982385 @default.
- W1590444888 cites W1611926448 @default.
- W1590444888 cites W1662084969 @default.
- W1590444888 cites W1868696300 @default.
- W1590444888 cites W1965918908 @default.
- W1590444888 cites W1966342030 @default.
- W1590444888 cites W1967710981 @default.
- W1590444888 cites W1968232819 @default.
- W1590444888 cites W1969535658 @default.
- W1590444888 cites W1974888898 @default.
- W1590444888 cites W1975880946 @default.
- W1590444888 cites W1976483646 @default.
- W1590444888 cites W1977253304 @default.
- W1590444888 cites W1977984201 @default.
- W1590444888 cites W1981107470 @default.
- W1590444888 cites W1985834976 @default.
- W1590444888 cites W1986053200 @default.
- W1590444888 cites W1987078254 @default.
- W1590444888 cites W1989963144 @default.
- W1590444888 cites W1990098432 @default.
- W1590444888 cites W1990634170 @default.
- W1590444888 cites W1990648838 @default.
- W1590444888 cites W1992242429 @default.
- W1590444888 cites W1993279107 @default.
- W1590444888 cites W1994108379 @default.
- W1590444888 cites W1994391974 @default.
- W1590444888 cites W1994778927 @default.
- W1590444888 cites W1996545689 @default.
- W1590444888 cites W1996701312 @default.
- W1590444888 cites W1996903255 @default.
- W1590444888 cites W1998534634 @default.
- W1590444888 cites W2001097099 @default.
- W1590444888 cites W2001700822 @default.
- W1590444888 cites W2005440281 @default.
- W1590444888 cites W2006495469 @default.
- W1590444888 cites W2008388984 @default.
- W1590444888 cites W2009500363 @default.
- W1590444888 cites W2010228315 @default.
- W1590444888 cites W2010796461 @default.
- W1590444888 cites W2010977079 @default.
- W1590444888 cites W2011189203 @default.
- W1590444888 cites W2013491677 @default.
- W1590444888 cites W2014102365 @default.
- W1590444888 cites W2014736685 @default.
- W1590444888 cites W2014780970 @default.
- W1590444888 cites W2017340995 @default.
- W1590444888 cites W2017952116 @default.
- W1590444888 cites W2023104469 @default.
- W1590444888 cites W2023791237 @default.
- W1590444888 cites W2025115344 @default.
- W1590444888 cites W2025211734 @default.
- W1590444888 cites W2026241593 @default.
- W1590444888 cites W2026881910 @default.
- W1590444888 cites W2029349973 @default.
- W1590444888 cites W2029383767 @default.
- W1590444888 cites W2029749273 @default.
- W1590444888 cites W20305632 @default.
- W1590444888 cites W2030855909 @default.
- W1590444888 cites W2032369546 @default.
- W1590444888 cites W2032381925 @default.
- W1590444888 cites W2034033759 @default.
- W1590444888 cites W2034832715 @default.
- W1590444888 cites W2035639831 @default.
- W1590444888 cites W2036240221 @default.
- W1590444888 cites W2036271174 @default.
- W1590444888 cites W2036697585 @default.
- W1590444888 cites W2036944284 @default.
- W1590444888 cites W2037917071 @default.
- W1590444888 cites W2039641449 @default.
- W1590444888 cites W2040040639 @default.
- W1590444888 cites W2041238096 @default.
- W1590444888 cites W2042066665 @default.
- W1590444888 cites W2043764483 @default.
- W1590444888 cites W2043898128 @default.
- W1590444888 cites W2045678504 @default.
- W1590444888 cites W2045713969 @default.
- W1590444888 cites W2046926512 @default.
- W1590444888 cites W2047433495 @default.
- W1590444888 cites W2047695438 @default.
- W1590444888 cites W2048369172 @default.
- W1590444888 cites W2054119278 @default.
- W1590444888 cites W2054609339 @default.
- W1590444888 cites W2057768522 @default.