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- W1590488405 abstract "Red cell transfusion is an important therapy for inherited anaemias such as β thalassaemia major and sickle cell disease. Chronic HCV infection is common in adult patients and in those treated in countries with less stringent exclusion of infected blood donors. There is an increased risk of progressive hepatic fibrosis because of the interaction between HCV and hepatic iron overload, and hepatocellular carcinoma is becoming more commonly reported. Recurrent intrahepatic vaso-occlusive events in the case of sickle cell disease may also be a risk factor. Antiviral therapy should be considered, particularly if there is evidence of fibrosis on biopsy. A number of small studies of combination interferon and ribavirin have shown sustained virological response in 40–70%, and this therapy should be made available despite the contraindication specified in the prescribing information for Copegus. Ribavirin-induced haemolysis can be managed in thalassaemia major by increasing the frequency of regular transfusion, and by regular transfusion of non-transfusion-requiring sickle cell patients for the duration of therapy. Additional adverse events can occur during therapy, and it is important that these patients are managed in a joint clinic by a haematologist and hepatologist." @default.
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- W1590488405 date "2010-03-10" @default.
- W1590488405 modified "2023-10-14" @default.
- W1590488405 title "Management of HCV Infection in Patients with Thalassemia and Sickle Cell Disease" @default.
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- W1590488405 doi "https://doi.org/10.1002/9781444319590.ch10" @default.
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