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• W1590514634 endingPage "23" @default.
• W1590514634 startingPage "13" @default.
• W1590514634 abstract "Nuclear factor-kappaB (NFKB) is a transcription factor with a pivotal role in inducing genes involved in physiological processes as well as in the response to injury and infection. A model has been proposed whereby the diverse agents that activate NFkappaB do so by increasing oxidative stress within the cell. Activation of NFkappaB involves the phosphorylation and subsequent degradation of an inhibitory protein, IKB, and recently many of the proximal kinases and adaptor molecules involved in this process have been elucidated. Additionally, we now understand in detail the NFkappaB activation pathway from cell membrane to nucleus for interleukin-1 (IL-1) and tumour necrosis factor (TNF). This review revisits the evidence for the oxidative stress model in light of these recent findings, and finds little in the new information to rationalise or justify a central role for oxidative stress in NF-kappaB activation. We demonstrate that much of the evidence for the involvement of oxidative stress is either specific to a stimulus in a particular cell line or open to reinterpretation. In particular, the activation of NFkappaB by hydrogen peroxide is cell-specific and distinct from physiological activators such as IL-1 and TNF, while inhibition by antioxidants, also found to be cell- and stimulus-specific, can involve diverse and unexpected targets which may be distinct from redox modulation. We conclude that in most cases the role of oxidative stress in NF-kappaB activation is at best facilitatory rather than causal, if a role exists at all. In addition, other evidence suggests a role for lipid peroxides in pathways where such a role exists. In future, when a role for oxidative stress in a pathway is postulated, the challenge will be to show which particular kinases or adaptor molecules, if any, are redox-modulated." @default.
• W1590514634 created "2016-06-24" @default.
• W1590514634 creator A5011747545 @default.
• W1590514634 creator A5069107406 @default.
• W1590514634 date "2000-01-01" @default.
• W1590514634 modified "2023-09-27" @default.
• W1590514634 title "Oxidative stress and nuclear factor-κB activation" @default.
• W1590514634 cites W1492571211 @default.
• W1590514634 cites W1510592624 @default.
• W1590514634 cites W1513020808 @default.
• W1590514634 cites W1545202460 @default.
• W1590514634 cites W1568529372 @default.
• W1590514634 cites W1571399843 @default.
• W1590514634 cites W1575383081 @default.
• W1590514634 cites W1577403013 @default.
• W1590514634 cites W1579092429 @default.
• W1590514634 cites W1598869478 @default.
• W1590514634 cites W1638074023 @default.
• W1590514634 cites W1763097477 @default.
• W1590514634 cites W1866959613 @default.
• W1590514634 cites W1920234850 @default.
• W1590514634 cites W1949043027 @default.
• W1590514634 cites W1966986944 @default.
• W1590514634 cites W1969158591 @default.
• W1590514634 cites W1973328612 @default.
• W1590514634 cites W1978068747 @default.
• W1590514634 cites W1978701756 @default.
• W1590514634 cites W1979520552 @default.
• W1590514634 cites W1979634801 @default.
• W1590514634 cites W1980768491 @default.
• W1590514634 cites W1984172682 @default.
• W1590514634 cites W1984380214 @default.
• W1590514634 cites W1987767047 @default.
• W1590514634 cites W1989844987 @default.
• W1590514634 cites W1993029299 @default.
• W1590514634 cites W1993448382 @default.
• W1590514634 cites W1995317658 @default.
• W1590514634 cites W1997509253 @default.
• W1590514634 cites W1997577319 @default.
• W1590514634 cites W1997865069 @default.
• W1590514634 cites W1999327808 @default.
• W1590514634 cites W2012744796 @default.
• W1590514634 cites W2028501194 @default.
• W1590514634 cites W2030592815 @default.
• W1590514634 cites W2031433004 @default.
• W1590514634 cites W2031643961 @default.
• W1590514634 cites W2036849587 @default.
• W1590514634 cites W2037283275 @default.
• W1590514634 cites W2040470926 @default.
• W1590514634 cites W2040922023 @default.
• W1590514634 cites W2048158801 @default.
• W1590514634 cites W2048569323 @default.
• W1590514634 cites W2049731820 @default.
• W1590514634 cites W2050576725 @default.
• W1590514634 cites W2051895005 @default.
• W1590514634 cites W2054797013 @default.
• W1590514634 cites W2055426473 @default.
• W1590514634 cites W2056831005 @default.
• W1590514634 cites W2057737390 @default.
• W1590514634 cites W2058012509 @default.
• W1590514634 cites W2061726942 @default.
• W1590514634 cites W2062205148 @default.
• W1590514634 cites W2063081233 @default.
• W1590514634 cites W2064067114 @default.
• W1590514634 cites W2068001141 @default.
• W1590514634 cites W2069104210 @default.
• W1590514634 cites W2072569792 @default.
• W1590514634 cites W2074303363 @default.
• W1590514634 cites W2077575210 @default.
• W1590514634 cites W2079535929 @default.
• W1590514634 cites W2085837280 @default.
• W1590514634 cites W2093098202 @default.
• W1590514634 cites W2096678608 @default.
• W1590514634 cites W2101257770 @default.
• W1590514634 cites W2104324075 @default.
• W1590514634 cites W2110591890 @default.
• W1590514634 cites W2122417664 @default.
• W1590514634 cites W2122723613 @default.
• W1590514634 cites W2122748202 @default.
• W1590514634 cites W2147986625 @default.
• W1590514634 cites W2148937254 @default.
• W1590514634 cites W2151892297 @default.
• W1590514634 cites W2156861225 @default.
• W1590514634 cites W2159567970 @default.
• W1590514634 cites W2159979956 @default.
• W1590514634 cites W2160906312 @default.
• W1590514634 cites W2160991051 @default.
• W1590514634 cites W2167800649 @default.
• W1590514634 cites W2179490209 @default.
• W1590514634 cites W2207929855 @default.
• W1590514634 cites W220993559 @default.
• W1590514634 cites W2341049818 @default.
• W1590514634 cites W2401416851 @default.
• W1590514634 cites W258569422 @default.
• W1590514634 cites W2728081960 @default.
• W1590514634 cites W2762075333 @default.
• W1590514634 cites W43967522 @default.
• W1590514634 doi "https://doi.org/10.1016/s0006-2952(99)00296-8" @default.

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