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- W1590640462 abstract "Abstract Multiple cytokines are secreted in the brain during pro‐inflammatory conditions and likely affect neuron survival. Previously, we demonstrated that glutamate and tumor necrosis factor alpha (TNFα) kill neurons via activation of the N ‐methyl‐ d ‐aspartate (NMDA) and TNFα receptors, respectively. This report continues characterizing the signaling cross‐talk pathway initiated during this inflammation‐related mechanism of death. Stimulation of mouse cortical neuron cultures with TNFα results in a transient increase in NMDA receptor‐dependent calcium influx that is additive with NMDA stimulation and inhibited by pre‐treatment with the NMDA receptor antagonist, dl ‐2‐amino‐5‐phosphonovaleric acid, or the α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate/kainate receptor antagonist, 6,7‐dinitroquinoxaline‐2,3‐dione. Pre‐treatment with N‐type calcium channel antagonist, ω‐conotoxin, or the voltage‐gated sodium channel antagonist, tetrodotoxin, also prevents the TNFα‐stimulated calcium influx. Combined TNFα and NMDA stimulation results in a transient increase in activity of extracellular signal‐regulated kinases (ERKs) and c‐Jun N‐terminal kinases (JNKs). Specific inhibition of ERKs but not JNKs is protective against TNFα and NMDA‐dependent death. Death is mediated via the low‐affinity TNFα receptor, TNFRII, as agonist antibodies for TNFRII but not TNFRI stimulate NMDA receptor‐dependent calcium influx and death. These data demonstrate how microglial pro‐inflammatory secretions including TNFα can acutely facilitate glutamate‐dependent neuron death." @default.
- W1590640462 created "2016-06-24" @default.
- W1590640462 creator A5043778889 @default.
- W1590640462 creator A5067598023 @default.
- W1590640462 creator A5082568887 @default.
- W1590640462 creator A5086869525 @default.
- W1590640462 date "2006-11-09" @default.
- W1590640462 modified "2023-10-12" @default.
- W1590640462 title "Tumor necrosis factor alpha stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death" @default.
- W1590640462 cites W1490228662 @default.
- W1590640462 cites W1495983806 @default.
- W1590640462 cites W1528562972 @default.
- W1590640462 cites W1529774113 @default.
- W1590640462 cites W1542136448 @default.
- W1590640462 cites W1543601456 @default.
- W1590640462 cites W1570092599 @default.
- W1590640462 cites W1724950598 @default.
- W1590640462 cites W1954347758 @default.
- W1590640462 cites W1963761369 @default.
- W1590640462 cites W1971751650 @default.
- W1590640462 cites W1975298116 @default.
- W1590640462 cites W1976509949 @default.
- W1590640462 cites W1981513372 @default.
- W1590640462 cites W1984057909 @default.
- W1590640462 cites W1984213418 @default.
- W1590640462 cites W1988264669 @default.
- W1590640462 cites W1990362370 @default.
- W1590640462 cites W1991538811 @default.
- W1590640462 cites W1994148496 @default.
- W1590640462 cites W1995463676 @default.
- W1590640462 cites W1996993676 @default.
- W1590640462 cites W2002008252 @default.
- W1590640462 cites W2005509576 @default.
- W1590640462 cites W2005774521 @default.
- W1590640462 cites W2007231568 @default.
- W1590640462 cites W2008854365 @default.
- W1590640462 cites W2009695612 @default.
- W1590640462 cites W2012797849 @default.
- W1590640462 cites W2013906894 @default.
- W1590640462 cites W2016575029 @default.
- W1590640462 cites W2017189350 @default.
- W1590640462 cites W2019845863 @default.
- W1590640462 cites W2020583309 @default.
- W1590640462 cites W2024036641 @default.
- W1590640462 cites W2028705859 @default.
- W1590640462 cites W2031588616 @default.
- W1590640462 cites W2044480962 @default.
- W1590640462 cites W2049378629 @default.
- W1590640462 cites W2049623666 @default.
- W1590640462 cites W2049659704 @default.
- W1590640462 cites W2051861534 @default.
- W1590640462 cites W2052205355 @default.
- W1590640462 cites W2052850418 @default.
- W1590640462 cites W2058167344 @default.
- W1590640462 cites W2058176457 @default.
- W1590640462 cites W2058702798 @default.
- W1590640462 cites W2059995799 @default.
- W1590640462 cites W2062406681 @default.
- W1590640462 cites W2064520650 @default.
- W1590640462 cites W2066347230 @default.
- W1590640462 cites W2067185300 @default.
- W1590640462 cites W2067712423 @default.
- W1590640462 cites W2069434863 @default.
- W1590640462 cites W2069681479 @default.
- W1590640462 cites W2071992832 @default.
- W1590640462 cites W2072380594 @default.
- W1590640462 cites W2074709811 @default.
- W1590640462 cites W2079966712 @default.
- W1590640462 cites W2081559406 @default.
- W1590640462 cites W2086262311 @default.
- W1590640462 cites W2086783008 @default.
- W1590640462 cites W2088335573 @default.
- W1590640462 cites W2093202085 @default.
- W1590640462 cites W2101068306 @default.
- W1590640462 cites W2103834862 @default.
- W1590640462 cites W2109596679 @default.
- W1590640462 cites W2116784956 @default.
- W1590640462 cites W2126092103 @default.
- W1590640462 cites W2128635872 @default.
- W1590640462 cites W2132680120 @default.
- W1590640462 cites W2135482947 @default.
- W1590640462 cites W2138340537 @default.
- W1590640462 cites W2140864016 @default.
- W1590640462 cites W2142943268 @default.
- W1590640462 cites W2143399447 @default.
- W1590640462 cites W2146346171 @default.
- W1590640462 cites W2202858363 @default.
- W1590640462 cites W2325880234 @default.
- W1590640462 cites W4293247451 @default.
- W1590640462 cites W4294253695 @default.
- W1590640462 cites W4313635391 @default.
- W1590640462 cites W4214779313 @default.
- W1590640462 doi "https://doi.org/10.1111/j.1471-4159.2006.04330.x" @default.
- W1590640462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3619402" @default.
- W1590640462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17241124" @default.
- W1590640462 hasPublicationYear "2006" @default.
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