Matches in SemOpenAlex for { <https://semopenalex.org/work/W159067465> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W159067465 endingPage "104" @default.
- W159067465 startingPage "57" @default.
- W159067465 abstract "Currently, approximately 40 drugs are registered for the chemotherapeutic treatment of cancer, the vast majority of which either interact directly with DNA (eg, alkylating, methylating, platinating agents, topoisomerase inhibitors), or affect DNA synthesis (antimetabolites). Whilst such agents remain of great importance in combination chemotherapy regimens, many cancer drug discovery groups have questioned whether any further significant gains may be made through the development of novel DNA-interactive drugs. Such agents tend to be associated with dose-limiting antiproliferative tissue toxicities (eg, myelo-suppression, nausea and vomiting, diarrhea or mucositis) which is indicative of their general lack of selectivity in targeting tumor versus normal tissue DNA. Perhaps surprisingly to some, Dr D Von Hoff (University of Texas Health Science Center, San Antonio, Texas, USA) proposed that the investigation of DNA-interactive agents is still yielding some promising agents. He illustrated this with the following new agents." @default.
- W159067465 created "2016-06-24" @default.
- W159067465 creator A5041062763 @default.
- W159067465 date "2006-11-22" @default.
- W159067465 modified "2023-09-26" @default.
- W159067465 title "DNA-Interactive Agents" @default.
- W159067465 doi "https://doi.org/10.1201/9781420008906-7" @default.
- W159067465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18465568" @default.
- W159067465 hasPublicationYear "2006" @default.
- W159067465 type Work @default.
- W159067465 sameAs 159067465 @default.
- W159067465 citedByCount "1" @default.
- W159067465 countsByYear W1590674652021 @default.
- W159067465 crossrefType "book-chapter" @default.
- W159067465 hasAuthorship W159067465A5041062763 @default.
- W159067465 hasConcept C121608353 @default.
- W159067465 hasConcept C126322002 @default.
- W159067465 hasConcept C127413603 @default.
- W159067465 hasConcept C143998085 @default.
- W159067465 hasConcept C147897179 @default.
- W159067465 hasConcept C188198153 @default.
- W159067465 hasConcept C2776694085 @default.
- W159067465 hasConcept C2778496288 @default.
- W159067465 hasConcept C2780035454 @default.
- W159067465 hasConcept C2780580376 @default.
- W159067465 hasConcept C2780852908 @default.
- W159067465 hasConcept C2983288658 @default.
- W159067465 hasConcept C502942594 @default.
- W159067465 hasConcept C54355233 @default.
- W159067465 hasConcept C552990157 @default.
- W159067465 hasConcept C71924100 @default.
- W159067465 hasConcept C78519656 @default.
- W159067465 hasConcept C86803240 @default.
- W159067465 hasConcept C98274493 @default.
- W159067465 hasConceptScore W159067465C121608353 @default.
- W159067465 hasConceptScore W159067465C126322002 @default.
- W159067465 hasConceptScore W159067465C127413603 @default.
- W159067465 hasConceptScore W159067465C143998085 @default.
- W159067465 hasConceptScore W159067465C147897179 @default.
- W159067465 hasConceptScore W159067465C188198153 @default.
- W159067465 hasConceptScore W159067465C2776694085 @default.
- W159067465 hasConceptScore W159067465C2778496288 @default.
- W159067465 hasConceptScore W159067465C2780035454 @default.
- W159067465 hasConceptScore W159067465C2780580376 @default.
- W159067465 hasConceptScore W159067465C2780852908 @default.
- W159067465 hasConceptScore W159067465C2983288658 @default.
- W159067465 hasConceptScore W159067465C502942594 @default.
- W159067465 hasConceptScore W159067465C54355233 @default.
- W159067465 hasConceptScore W159067465C552990157 @default.
- W159067465 hasConceptScore W159067465C71924100 @default.
- W159067465 hasConceptScore W159067465C78519656 @default.
- W159067465 hasConceptScore W159067465C86803240 @default.
- W159067465 hasConceptScore W159067465C98274493 @default.
- W159067465 hasLocation W1590674651 @default.
- W159067465 hasLocation W1590674652 @default.
- W159067465 hasOpenAccess W159067465 @default.
- W159067465 hasPrimaryLocation W1590674651 @default.
- W159067465 hasRelatedWork W150051096 @default.
- W159067465 hasRelatedWork W1958319993 @default.
- W159067465 hasRelatedWork W1983173757 @default.
- W159067465 hasRelatedWork W2015416409 @default.
- W159067465 hasRelatedWork W2092045607 @default.
- W159067465 hasRelatedWork W2421020884 @default.
- W159067465 hasRelatedWork W2434503764 @default.
- W159067465 hasRelatedWork W2549638621 @default.
- W159067465 hasRelatedWork W3032130105 @default.
- W159067465 hasRelatedWork W2338742873 @default.
- W159067465 isParatext "false" @default.
- W159067465 isRetracted "false" @default.
- W159067465 magId "159067465" @default.
- W159067465 workType "book-chapter" @default.