Matches in SemOpenAlex for { <https://semopenalex.org/work/W1590705129> ?p ?o ?g. }
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- W1590705129 abstract "During the last decade, advances in experimental techniques and quantitative modelling have resulted in the development of the calyx of Held as one of the best preparations in which to study synaptic transmission. Here we review some of these advances, including simultaneous recording of pre‐ and postsynaptic currents, measuring the Ca 2+ sensitivity of transmitter release, reconstructing the 3‐D anatomy at the electron microscope (EM) level, and modelling the buffered diffusion of Ca 2+ in the nerve terminal. An important outcome of these studies is an improved understanding of the Ca 2+ signal that controls phasic transmitter release. This article illustrates the spatial and temporal aspects of the three main steps in the presynaptic signalling cascade: Ca 2+ influx through voltage‐gated calcium channels, buffered Ca 2+ diffusion from the channels to releasable vesicles, and activation of the Ca 2+ sensor for release. Particular emphasis is placed on how presynaptic Ca 2+ buffers affect the Ca 2+ signal and thus the amplitude and time course of the release probability. Since many aspects of the signalling cascade were first conceived with reference to the squid giant presynaptic terminal, we include comparisons with the squid model and revisit some of its implications. Whilst the characteristics of buffered Ca 2+ diffusion presented here are based on the calyx of Held, we demonstrate the circumstances under which they may be valid for other nerve terminals at mammalian CNS synapses." @default.
- W1590705129 created "2016-06-24" @default.
- W1590705129 creator A5057994106 @default.
- W1590705129 creator A5082041058 @default.
- W1590705129 creator A5084635195 @default.
- W1590705129 date "2003-03-01" @default.
- W1590705129 modified "2023-10-18" @default.
- W1590705129 title "The Hodgkin–Huxley–Katz Prize Lecture" @default.
- W1590705129 cites W129243571 @default.
- W1590705129 cites W1490183365 @default.
- W1590705129 cites W1506437391 @default.
- W1590705129 cites W1517253433 @default.
- W1590705129 cites W1520756199 @default.
- W1590705129 cites W1622189158 @default.
- W1590705129 cites W1642181682 @default.
- W1590705129 cites W1650765334 @default.
- W1590705129 cites W1664184517 @default.
- W1590705129 cites W1670760110 @default.
- W1590705129 cites W1877594537 @default.
- W1590705129 cites W192776057 @default.
- W1590705129 cites W1955716838 @default.
- W1590705129 cites W1964596341 @default.
- W1590705129 cites W1965893090 @default.
- W1590705129 cites W1970499295 @default.
- W1590705129 cites W1971405760 @default.
- W1590705129 cites W1972411901 @default.
- W1590705129 cites W1972438346 @default.
- W1590705129 cites W1978936152 @default.
- W1590705129 cites W1979400171 @default.
- W1590705129 cites W1982073244 @default.
- W1590705129 cites W1983078818 @default.
- W1590705129 cites W1985940938 @default.
- W1590705129 cites W1990220309 @default.
- W1590705129 cites W1994123659 @default.
- W1590705129 cites W1996892917 @default.
- W1590705129 cites W1998596214 @default.
- W1590705129 cites W2003230139 @default.
- W1590705129 cites W2007263885 @default.
- W1590705129 cites W2013902743 @default.
- W1590705129 cites W2016880507 @default.
- W1590705129 cites W2017441152 @default.
- W1590705129 cites W2017847991 @default.
- W1590705129 cites W2018170523 @default.
- W1590705129 cites W2027656943 @default.
- W1590705129 cites W2030419485 @default.
- W1590705129 cites W2032562864 @default.
- W1590705129 cites W2035347592 @default.
- W1590705129 cites W2036402923 @default.
- W1590705129 cites W2037620792 @default.
- W1590705129 cites W2037844026 @default.
- W1590705129 cites W2038127888 @default.
- W1590705129 cites W2042447398 @default.
- W1590705129 cites W2046901610 @default.
- W1590705129 cites W2047397502 @default.
- W1590705129 cites W2049253593 @default.
- W1590705129 cites W2065590047 @default.
- W1590705129 cites W2067995523 @default.
- W1590705129 cites W2072816770 @default.
- W1590705129 cites W2075437459 @default.
- W1590705129 cites W2076193112 @default.
- W1590705129 cites W2078039225 @default.
- W1590705129 cites W2078039971 @default.
- W1590705129 cites W2078068750 @default.
- W1590705129 cites W2079858153 @default.
- W1590705129 cites W2080778713 @default.
- W1590705129 cites W2082089816 @default.
- W1590705129 cites W2087758815 @default.
- W1590705129 cites W2090662268 @default.
- W1590705129 cites W2091270303 @default.
- W1590705129 cites W2091848186 @default.
- W1590705129 cites W2094930349 @default.
- W1590705129 cites W2098599651 @default.
- W1590705129 cites W2103048971 @default.
- W1590705129 cites W2104801499 @default.
- W1590705129 cites W2108204473 @default.
- W1590705129 cites W2115908743 @default.
- W1590705129 cites W2119494356 @default.
- W1590705129 cites W2119825883 @default.
- W1590705129 cites W2122383890 @default.
- W1590705129 cites W2124486024 @default.
- W1590705129 cites W2125913150 @default.
- W1590705129 cites W2127431229 @default.
- W1590705129 cites W2129794085 @default.
- W1590705129 cites W2131338541 @default.
- W1590705129 cites W2131844980 @default.
- W1590705129 cites W2134949719 @default.
- W1590705129 cites W2139055855 @default.
- W1590705129 cites W2139316214 @default.
- W1590705129 cites W2149394947 @default.
- W1590705129 cites W2153456027 @default.
- W1590705129 cites W2154606229 @default.
- W1590705129 cites W2156796661 @default.
- W1590705129 cites W2158561409 @default.
- W1590705129 cites W2166831133 @default.
- W1590705129 cites W2176475744 @default.
- W1590705129 cites W2309871694 @default.
- W1590705129 cites W2408458605 @default.
- W1590705129 cites W2412767092 @default.