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- W1590749097 abstract "Bacterial DNA segregation takes place in an active and ordered fashion. In the case of Escherichia coli plasmid R1, the partitioning system (par) separates paired plasmid copies and moves them to opposite cell poles. Here we address the mechanism by which the three components of the R1 par system act together to generate the force required for plasmid movement during segregation. ParR protein binds cooperatively to the centromeric parC DNA region, thereby forming a complex that interacts with the filament-forming actin-like ParM protein in an ATP-dependent manner, suggesting that plasmid movement is powered by insertional polymerization of ParM. Consistently, we find that segregating plasmids are positioned at the ends of extending ParM filaments. Thus, the process of R1 plasmid segregation in E. coli appears to be mechanistically analogous to the actin-based motility operating in eukaryotic cells. In addition, we find evidence suggesting that plasmid pairing is required for ParM polymerization." @default.
- W1590749097 created "2016-06-24" @default.
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- W1590749097 date "2003-12-01" @default.
- W1590749097 modified "2023-10-16" @default.
- W1590749097 title "Bacterial Mitosis" @default.
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- W1590749097 doi "https://doi.org/10.1016/s1097-2765(03)00451-9" @default.
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