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- W1590839468 abstract "National Rotavirus Surveillance in the Gambia was initiated in October 2011 to investigate the prevalence and the burden of rotavirus gastroenteritis in infants’ ˂ 5 years of age. The aim was to generate data for decision making on the introduction of rotavirus vaccine and to provide base-line data for monitoring the impact of vaccination on the burden of rotavirus disease. Vaccination is the most effective method for preventing rotavirus infection. Pre-vaccination data, on the prevalence and burden of rotavirus genotypes, is crucial in monitoring vaccine efficacy. The Gambia introduced rotavirus vaccine (rota Teq) into routine childhood immunization in August 2013. Sentinel surveillance site at the Gambia’s main referral hospital (EFSTH) used the WHO standard Case investigation protocol from 2011-2014. Children under 5 years of age, hospitalized mainly for the treatment of acute gastroenteritis, were enrolled and stool samples were collected and screened for group A rotavirus using Enzyme immunoassay. Confirmed positive cases were genotyped by Polymerase chain reaction at the regional Reference lab in Ghana. The results shows that from 265 stool samples from enrolled infants (2012-2014), 63 (24%) were ELISA positive for rotavirus. Infants’ 0-11 months of age comprised 11% and infants 12-23 months: 8% and 24-59 months: 5%. Rotavirus was detected throughout the year with a peak prevalence period from January to April. There was mixed rotavirus infection: predominantly genotype G9P [8] in 2013, G12P [8] in 2014. The change in serotypes from 2013 to 2014 was statistically significant. There was an unusual genotype G6P [6] observed which may be due to the result of Zoonotic infection. These results implicated rotavirus infection as a major cause of severe diarrhoea in the Gambia. In the conclusions; we can say that the rotavirus infection is common among Gambian infants. The introduction of the vaccine (rota Teq) in 2013 will serve as a safe and effective intervention to reduce the severity of rotavirus infection. The established surveillance system will continue to monitor and assess the impact and severity of rotavirus disease." @default.
- W1590839468 created "2016-06-24" @default.
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- W1590839468 date "2015-01-28" @default.
- W1590839468 modified "2023-09-28" @default.
- W1590839468 title "Hospital-Based Pre-Vaccination Surveillance of Rotavirus Gastroenteritis Disease in Infants Less Than 5 Years of Age in the Gambia: 2011-2014" @default.
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