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• W1590870105 endingPage "718" @default.
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• W1590870105 abstract "Oxidative stress and neurotrophic factors are involved in the pathophysiology of bipolar disorder (BD). Alpha-lipoic acid (ALA) is a naturally occurring compound with strong antioxidant properties. The present study investigated ALA effects in an amphetamine-induced model of mania.In the reversal protocol, adult mice were first given d-amphetamine (AMPH) 2 mg/kg, intraperitoneally (i.p.) or saline for 14 days. Between days 8 and 14, the animals received ALA 50 or 100 mg/kg orally, lithium (Li) 47.5 mg/kg i.p., or saline. In the prevention paradigm, mice were pretreated with ALA, Li, or saline prior to AMPH. Locomotor activity was assessed in the open-field task. Superoxide dismutase (SOD) activity, reduced glutathione (GSH), and thiobarbituric acid-reactive substance (TBARS) levels were evaluated in the prefrontal cortex (PFC), hippocampus (HC), and striatum (ST). Brain-derived neurotrophic factor (BDNF) levels were measured in the HC.ALA and Li prevented and reversed the AMPH-induced increase in locomotor activity. PREVENTION MODEL: ALA and Li co-administration with AMPH prevented the decrease in SOD activity induced by AMPH in the HC and ST, respectively; ALA and Li prevented GSH alteration in the HC and TBARS formation in all brain areas studied. REVERSAL MODEL: ALA reversed the decrease in SOD activity in the ST. TBARS formation was reversed by ALA and Li in all brain areas. Furthermore, ALA reversed AMPH-induced decreases in BDNF and GSH in the HC.Our findings showed that ALA, similarly to Li, is effective in reversing and preventing AMPH-induced behavioral and neurochemical alterations, providing a rationale for the design of clinical trials investigating ALA's possible antimanic effect." @default.
• W1590870105 created "2016-06-24" @default.
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• W1590870105 date "2012-08-17" @default.
• W1590870105 modified "2023-09-26" @default.
• W1590870105 title "Effects of alpha-lipoic acid in an animal model of mania induced by<scp>d</scp>-amphetamine" @default.
• W1590870105 cites W1576683498 @default.
• W1590870105 cites W1588570886 @default.
• W1590870105 cites W1965696818 @default.
• W1590870105 cites W1966279131 @default.
• W1590870105 cites W1967922486 @default.
• W1590870105 cites W1973652904 @default.
• W1590870105 cites W1974297683 @default.
• W1590870105 cites W1982844998 @default.
• W1590870105 cites W1990663296 @default.
• W1590870105 cites W1992670283 @default.
• W1590870105 cites W1993562661 @default.
• W1590870105 cites W1993873667 @default.
• W1590870105 cites W1998089508 @default.
• W1590870105 cites W1999747923 @default.
• W1590870105 cites W2000915966 @default.
• W1590870105 cites W2003058805 @default.
• W1590870105 cites W2007372385 @default.
• W1590870105 cites W2011152776 @default.
• W1590870105 cites W2011441861 @default.
• W1590870105 cites W2011805483 @default.
• W1590870105 cites W2016756266 @default.
• W1590870105 cites W2016860528 @default.
• W1590870105 cites W2022851867 @default.
• W1590870105 cites W2024493236 @default.
• W1590870105 cites W2027737927 @default.
• W1590870105 cites W2029086034 @default.
• W1590870105 cites W2033772210 @default.
• W1590870105 cites W2042045791 @default.
• W1590870105 cites W2042120820 @default.
• W1590870105 cites W2042740180 @default.
• W1590870105 cites W2045769692 @default.
• W1590870105 cites W2046465340 @default.
• W1590870105 cites W2047703381 @default.
• W1590870105 cites W2047906079 @default.
• W1590870105 cites W2048835117 @default.
• W1590870105 cites W2053081724 @default.
• W1590870105 cites W2055669208 @default.
• W1590870105 cites W2060647184 @default.
• W1590870105 cites W2066549709 @default.
• W1590870105 cites W2067995765 @default.
• W1590870105 cites W2072574387 @default.
• W1590870105 cites W2073924899 @default.
• W1590870105 cites W2079268420 @default.
• W1590870105 cites W2080350725 @default.
• W1590870105 cites W2083524390 @default.
• W1590870105 cites W2091412647 @default.
• W1590870105 cites W2096505980 @default.
• W1590870105 cites W2098164623 @default.
• W1590870105 cites W2103127225 @default.
• W1590870105 cites W2104609773 @default.
• W1590870105 cites W2110790107 @default.
• W1590870105 cites W2112334970 @default.
• W1590870105 cites W2117304798 @default.
• W1590870105 cites W2117804236 @default.
• W1590870105 cites W2124801452 @default.
• W1590870105 cites W2129305481 @default.
• W1590870105 cites W2131622291 @default.
• W1590870105 cites W2138730565 @default.
• W1590870105 cites W2142476463 @default.
• W1590870105 cites W2156813826 @default.
• W1590870105 cites W2160797407 @default.
• W1590870105 cites W2174001102 @default.
• W1590870105 cites W4253487572 @default.
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• W1590870105 doi "https://doi.org/10.1111/j.1399-5618.2012.01046.x" @default.
• W1590870105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22897629" @default.
• W1590870105 hasPublicationYear "2012" @default.
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