FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1590919798> ?p ?o ?g. }

• W1590919798 endingPage "243" @default.
• W1590919798 startingPage "236" @default.
• W1590919798 abstract "Hypothalamic neuropeptides centrally modulate sexual arousal. However, the role of neuropeptides in peripheral arousal has been ignored. Vascular and non-vascular smooth muscle relaxation in the vagina is important for female sexual arousal. To date, in vitro studies have focused on vaginal strips with no studies on vaginal arteries. The aim of this study was to compare the effects of sexual hypothalamic neuropeptides on rabbit vaginal wall strips and arteries.Tissue bath and wire myography techniques were used to measure isometric tension from strips and arteries, respectively.Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) relaxed both preparations, effects that were only antagonized by the VIP/PACAP antagonist VIP6-28 (10 nM) and the PAC(1) antagonist PACAP 6-38 (1 microM). The melanocortin agonist alpha-melanocortin-stimulating hormone (1 microM), but not bremelanotide (1 microM), also relaxed both preparations. Oxytocin and vasopressin contracted vaginal preparations, which could be antagonized by the V(1A) antagonist SR 49059. Neuropeptide Y (NPY) and the NPY Y(1) agonist Leu(31), Pro(34) NPY only contracted arteries, which was antagonized by the NPY Y(1) receptor antagonist BIBP 3226. Melanin-concentrating hormone (MCH; 1 microM) contracted arteries.Hypothalamic neuropeptides can exert contractile and relaxant effects on vaginal strips and arteries. NPY Y(1), V(1A), MCH(1) antagonists as well as VIP/PAC(1) agonists may have therapeutic potential in both central and peripheral female sexual arousal. Differences in effect of neuropeptides between preparations raise the question of which preparation is important for female sexual arousal." @default.
• W1590919798 created "2016-06-24" @default.
• W1590919798 creator A5044189350 @default.
• W1590919798 creator A5053741174 @default.
• W1590919798 creator A5072002010 @default.
• W1590919798 creator A5073977880 @default.
• W1590919798 creator A5077788403 @default.
• W1590919798 creator A5084121128 @default.
• W1590919798 date "2008-09-01" @default.
• W1590919798 modified "2023-09-27" @default.
• W1590919798 title "Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle <i>in vitro</i>" @default.
• W1590919798 cites W1966490521 @default.
• W1590919798 cites W1968844749 @default.
• W1590919798 cites W1969534526 @default.
• W1590919798 cites W1973248802 @default.
• W1590919798 cites W1979067492 @default.
• W1590919798 cites W1979328473 @default.
• W1590919798 cites W1979616143 @default.
• W1590919798 cites W1982226325 @default.
• W1590919798 cites W1983548585 @default.
• W1590919798 cites W1987801401 @default.
• W1590919798 cites W1993602309 @default.
• W1590919798 cites W2000564722 @default.
• W1590919798 cites W2003333274 @default.
• W1590919798 cites W2008197263 @default.
• W1590919798 cites W2017195140 @default.
• W1590919798 cites W2018533048 @default.
• W1590919798 cites W2027467507 @default.
• W1590919798 cites W2034952552 @default.
• W1590919798 cites W2037317931 @default.
• W1590919798 cites W2047218085 @default.
• W1590919798 cites W2049212547 @default.
• W1590919798 cites W2053281052 @default.
• W1590919798 cites W2053764026 @default.
• W1590919798 cites W2057107727 @default.
• W1590919798 cites W2061409128 @default.
• W1590919798 cites W2062552335 @default.
• W1590919798 cites W2063158566 @default.
• W1590919798 cites W2067753073 @default.
• W1590919798 cites W2080826159 @default.
• W1590919798 cites W2085867569 @default.
• W1590919798 cites W2094630235 @default.
• W1590919798 cites W2095356195 @default.
• W1590919798 cites W2116058026 @default.
• W1590919798 cites W2133281927 @default.
• W1590919798 cites W2151437437 @default.
• W1590919798 cites W4233512644 @default.
• W1590919798 doi "https://doi.org/10.1038/bjp.2008.253" @default.
• W1590919798 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2538698" @default.
• W1590919798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18587425" @default.
• W1590919798 hasPublicationYear "2008" @default.
• W1590919798 type Work @default.
• W1590919798 sameAs 1590919798 @default.
• W1590919798 citedByCount "22" @default.
• W1590919798 countsByYear W15909197982012 @default.
• W1590919798 countsByYear W15909197982013 @default.
• W1590919798 countsByYear W15909197982014 @default.
• W1590919798 countsByYear W15909197982016 @default.
• W1590919798 countsByYear W15909197982017 @default.
• W1590919798 countsByYear W15909197982021 @default.
• W1590919798 countsByYear W15909197982023 @default.
• W1590919798 crossrefType "journal-article" @default.
• W1590919798 hasAuthorship W1590919798A5044189350 @default.
• W1590919798 hasAuthorship W1590919798A5053741174 @default.
• W1590919798 hasAuthorship W1590919798A5072002010 @default.
• W1590919798 hasAuthorship W1590919798A5073977880 @default.
• W1590919798 hasAuthorship W1590919798A5077788403 @default.
• W1590919798 hasAuthorship W1590919798A5084121128 @default.
• W1590919798 hasBestOaLocation W15909197982 @default.
• W1590919798 hasConcept C118303440 @default.
• W1590919798 hasConcept C126322002 @default.
• W1590919798 hasConcept C134018914 @default.
• W1590919798 hasConcept C170493617 @default.
• W1590919798 hasConcept C19519825 @default.
• W1590919798 hasConcept C71924100 @default.
• W1590919798 hasConcept C8330315 @default.
• W1590919798 hasConcept C93984277 @default.
• W1590919798 hasConceptScore W1590919798C118303440 @default.
• W1590919798 hasConceptScore W1590919798C126322002 @default.
• W1590919798 hasConceptScore W1590919798C134018914 @default.
• W1590919798 hasConceptScore W1590919798C170493617 @default.
• W1590919798 hasConceptScore W1590919798C19519825 @default.
• W1590919798 hasConceptScore W1590919798C71924100 @default.
• W1590919798 hasConceptScore W1590919798C8330315 @default.
• W1590919798 hasConceptScore W1590919798C93984277 @default.
• W1590919798 hasIssue "2" @default.
• W1590919798 hasLocation W15909197981 @default.
• W1590919798 hasLocation W15909197982 @default.
• W1590919798 hasLocation W15909197983 @default.
• W1590919798 hasLocation W15909197984 @default.
• W1590919798 hasOpenAccess W1590919798 @default.
• W1590919798 hasPrimaryLocation W15909197981 @default.
• W1590919798 hasRelatedWork W1577371918 @default.
• W1590919798 hasRelatedWork W1967501438 @default.
• W1590919798 hasRelatedWork W2027357022 @default.
• W1590919798 hasRelatedWork W2062633278 @default.
• W1590919798 hasRelatedWork W2067421416 @default.
• W1590919798 hasRelatedWork W2087759102 @default.

• next