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- W1591163516 abstract "The initiation of a cell signaling event relies primarily on interactions between molecules in the extracellular and cell-membrane space. Different types of molecules can serve as extracellular signals: hormones, cytokines, growth factors, and neurotransmitters secreted from distant or neighboring cells; antigens or antibodies free in solution or attached to (migrating) leukocytes or foreign cells; small soluble molecules; and the extracellular matrix. A careful regulation and coordination of the communication within the molecular signaling society is essential to the initiation of a signaling event, especially in the more complex multicellular organisms. The molecular recognition process that underlies a specific interaction is provided by the complementarity of the physicochemical and geometrical properties of the two protein surfaces to obtain an energetically favorable complex. The structural basis of conformational flexibility is difficult to assess experimentally, as the current available experimental methods in structural determination, i.e., X-ray crystallography, nuclear magnetic resonance spectroscopy, and electron microscopy, require a stable structure. Capturing the structures under different conditions (e.g., free and bound) or having thermodynamic and mutagenesis data can help to identify these changes or relate them to signal transduction activity." @default.
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- W1591163516 date "2010-01-01" @default.
- W1591163516 modified "2023-09-25" @default.
- W1591163516 title "Molecular Sociology" @default.
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- W1591163516 doi "https://doi.org/10.1016/b978-0-12-374145-5.00004-8" @default.
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