Matches in SemOpenAlex for { <https://semopenalex.org/work/W1591168462> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1591168462 endingPage "12980" @default.
- W1591168462 startingPage "12976" @default.
- W1591168462 abstract "We have mapped the regions of the glucocorticoid receptor important for killing the cells of a line of human leukemic lymphoblasts. The results show that the glucocorticoid response element-specific DNA binding domain is essential, and that only the sequence including the amino acids that subsume the first zinc finger through about half of the second zinc finger are absolutely necessary. Furthermore, in contrast to assays of receptor mutants for ability to increase gene transcription, deletion of the steroid binding domain results in a functionally constitutive receptor fully as active for cell kill as is the holoreceptor after addition of ligand. Deletion of most known transcription-activation, dimerization, ligand-binding, and nuclear translocation regions still leaves a receptor fragment highly potent for cell lethality. The results suggest that delivery systems for such a fragment could result in effective new therapies for certain malignancies." @default.
- W1591168462 created "2016-06-24" @default.
- W1591168462 creator A5006537594 @default.
- W1591168462 creator A5038643116 @default.
- W1591168462 creator A5053004653 @default.
- W1591168462 date "1991-07-01" @default.
- W1591168462 modified "2023-10-18" @default.
- W1591168462 title "Mapping the human glucocorticoid receptor for leukemic cell death" @default.
- W1591168462 cites W1213045642 @default.
- W1591168462 cites W1527910889 @default.
- W1591168462 cites W1559184092 @default.
- W1591168462 cites W1637312528 @default.
- W1591168462 cites W1974010456 @default.
- W1591168462 cites W1978045062 @default.
- W1591168462 cites W1980722886 @default.
- W1591168462 cites W1981814275 @default.
- W1591168462 cites W1985466236 @default.
- W1591168462 cites W1987557547 @default.
- W1591168462 cites W1992515328 @default.
- W1591168462 cites W1993637171 @default.
- W1591168462 cites W1998108444 @default.
- W1591168462 cites W2012324003 @default.
- W1591168462 cites W2030315227 @default.
- W1591168462 cites W2030666031 @default.
- W1591168462 cites W2048327622 @default.
- W1591168462 cites W2060903877 @default.
- W1591168462 cites W2063110155 @default.
- W1591168462 cites W2068609431 @default.
- W1591168462 cites W2084609653 @default.
- W1591168462 cites W2085124463 @default.
- W1591168462 cites W2088591863 @default.
- W1591168462 cites W2090112051 @default.
- W1591168462 cites W2104360623 @default.
- W1591168462 cites W2109133792 @default.
- W1591168462 cites W2129972061 @default.
- W1591168462 cites W2159545772 @default.
- W1591168462 cites W241168973 @default.
- W1591168462 cites W62916943 @default.
- W1591168462 doi "https://doi.org/10.1016/s0021-9258(18)98791-0" @default.
- W1591168462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2071584" @default.
- W1591168462 hasPublicationYear "1991" @default.
- W1591168462 type Work @default.
- W1591168462 sameAs 1591168462 @default.
- W1591168462 citedByCount "47" @default.
- W1591168462 crossrefType "journal-article" @default.
- W1591168462 hasAuthorship W1591168462A5006537594 @default.
- W1591168462 hasAuthorship W1591168462A5038643116 @default.
- W1591168462 hasAuthorship W1591168462A5053004653 @default.
- W1591168462 hasBestOaLocation W15911684621 @default.
- W1591168462 hasConcept C134018914 @default.
- W1591168462 hasConcept C170493617 @default.
- W1591168462 hasConcept C190283241 @default.
- W1591168462 hasConcept C2780841215 @default.
- W1591168462 hasConcept C31573885 @default.
- W1591168462 hasConcept C502942594 @default.
- W1591168462 hasConcept C54355233 @default.
- W1591168462 hasConcept C59493245 @default.
- W1591168462 hasConcept C86803240 @default.
- W1591168462 hasConcept C95444343 @default.
- W1591168462 hasConceptScore W1591168462C134018914 @default.
- W1591168462 hasConceptScore W1591168462C170493617 @default.
- W1591168462 hasConceptScore W1591168462C190283241 @default.
- W1591168462 hasConceptScore W1591168462C2780841215 @default.
- W1591168462 hasConceptScore W1591168462C31573885 @default.
- W1591168462 hasConceptScore W1591168462C502942594 @default.
- W1591168462 hasConceptScore W1591168462C54355233 @default.
- W1591168462 hasConceptScore W1591168462C59493245 @default.
- W1591168462 hasConceptScore W1591168462C86803240 @default.
- W1591168462 hasConceptScore W1591168462C95444343 @default.
- W1591168462 hasIssue "20" @default.
- W1591168462 hasLocation W15911684621 @default.
- W1591168462 hasOpenAccess W1591168462 @default.
- W1591168462 hasPrimaryLocation W15911684621 @default.
- W1591168462 hasRelatedWork W1578882671 @default.
- W1591168462 hasRelatedWork W1981540681 @default.
- W1591168462 hasRelatedWork W1991241272 @default.
- W1591168462 hasRelatedWork W2048445979 @default.
- W1591168462 hasRelatedWork W2119824100 @default.
- W1591168462 hasRelatedWork W2338237228 @default.
- W1591168462 hasRelatedWork W2359066614 @default.
- W1591168462 hasRelatedWork W2436275868 @default.
- W1591168462 hasRelatedWork W269771094 @default.
- W1591168462 hasRelatedWork W4318460051 @default.
- W1591168462 hasVolume "266" @default.
- W1591168462 isParatext "false" @default.
- W1591168462 isRetracted "false" @default.
- W1591168462 magId "1591168462" @default.
- W1591168462 workType "article" @default.