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• W1591229062 abstract "Inhibition of cholesteryl ester transfer protein (CETP), a key protein involved in reverse cholesterol transport, can lead to increases in high-density lipoprotein cholesterol (HDL-C) levels and thus, is under evaluation as an antiatherogenic strategy. Several CETP inhibitors have been under development including anacetrapib, dalcetrapib, and torcetrapib. To date, anacetrapib demonstrates the greatest HDL-C raising and low-density lipoprotein cholesterol (LDL-C) lowering potential. Phase I and phase II trials with anacetrapib have revealed that anacetrapib is well-tolerated and does not seem to possess the pressor effects associated with torcetrapib. This article will briefly review the HDL-C raising through CETP inhibition as an antiatherogenic strategy with a specific focus on anacetrapib." @default.
• W1591229062 created "2016-06-24" @default.
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• W1591229062 date "2010-04-09" @default.
• W1591229062 modified "2023-09-24" @default.
• W1591229062 title "Anacetrapib: Hope for CETP Inhibitors?" @default.
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• W1591229062 doi "https://doi.org/10.1111/j.1755-5922.2010.00142.x" @default.
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