Matches in SemOpenAlex for { <https://semopenalex.org/work/W1591283713> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1591283713 endingPage "44" @default.
- W1591283713 startingPage "39" @default.
- W1591283713 abstract "Object The authors' goal was to observe histopathological changes in the trigeminal nerve after Gamma Knife surgery (GKS) in rhesus monkeys, and to investigate the radiobiological mechanism of GKS for primary trigeminal neuralgia. The nerve length–dosage effect of irradiation is also discussed. Methods One of 5 rhesus monkeys randomly served as a control, and the other 4 monkeys were randomly administered a target radiation dose of 60, 70, 80, or 100 Gy (a different dose in each animal). The size of the collimator was 4 mm, and the target point was the trigeminal nerve root. In each experimental monkey, one side was exposed to single-target-point irradiation, and the contralateral side was exposed to double-target-point irradiation. After 6 months, the trigeminal nerve root was examined using light microscopy, transmission electron microscopy, and immunohistochemistry. Results At each radiation dose, the damage to the nerve tissue by single-target-point irradiation was identical to that caused by double-target-point irradiation. In the trigeminal nerve tissues of the monkeys irradiated with 60 and 70 Gy, there was limited nerve demyelination and degeneration, fragmentation, or loss of axons. In the trigeminal nerve tissue of the monkey irradiated with 80 Gy, the nerve tissue showed a disordered structure. In the trigeminal nerve tissue of the monkey irradiated with 100 Gy, there was severe derangement in the structure of the nerve tissue, and extensive demyelination, fragmentation, and loss of axons. Conclusions The target doses of 60 and 70 Gy have very little impact on the structure of the trigeminal nerve. Irradiation at 80 Gy can cause partial degeneration and loss of axons and demyelination. A 100-Gy dose can cause some necrosis of neurons. Comparing the single-target-point with the double-target-point irradiation, the extent of damage to the nerve tissue is identical, and no difference in the nerve length–dosage effect was found." @default.
- W1591283713 created "2016-06-24" @default.
- W1591283713 creator A5003841643 @default.
- W1591283713 creator A5046781760 @default.
- W1591283713 creator A5049550831 @default.
- W1591283713 creator A5054981462 @default.
- W1591283713 creator A5064688195 @default.
- W1591283713 date "2010-07-01" @default.
- W1591283713 modified "2023-09-25" @default.
- W1591283713 title "Gamma Knife irradiation–induced histopathological changes in the trigeminal nerves of rhesus monkeys" @default.
- W1591283713 cites W1967034756 @default.
- W1591283713 cites W1986207162 @default.
- W1591283713 cites W1988748844 @default.
- W1591283713 cites W2002505073 @default.
- W1591283713 cites W2028018997 @default.
- W1591283713 cites W2047237693 @default.
- W1591283713 cites W2066468112 @default.
- W1591283713 cites W2066559125 @default.
- W1591283713 cites W2144567223 @default.
- W1591283713 cites W2416126442 @default.
- W1591283713 doi "https://doi.org/10.3171/2010.1.jns091116" @default.
- W1591283713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20170304" @default.
- W1591283713 hasPublicationYear "2010" @default.
- W1591283713 type Work @default.
- W1591283713 sameAs 1591283713 @default.
- W1591283713 citedByCount "24" @default.
- W1591283713 countsByYear W15912837132012 @default.
- W1591283713 countsByYear W15912837132013 @default.
- W1591283713 countsByYear W15912837132014 @default.
- W1591283713 countsByYear W15912837132015 @default.
- W1591283713 countsByYear W15912837132016 @default.
- W1591283713 countsByYear W15912837132018 @default.
- W1591283713 countsByYear W15912837132019 @default.
- W1591283713 countsByYear W15912837132020 @default.
- W1591283713 countsByYear W15912837132021 @default.
- W1591283713 countsByYear W15912837132022 @default.
- W1591283713 crossrefType "journal-article" @default.
- W1591283713 hasAuthorship W1591283713A5003841643 @default.
- W1591283713 hasAuthorship W1591283713A5046781760 @default.
- W1591283713 hasAuthorship W1591283713A5049550831 @default.
- W1591283713 hasAuthorship W1591283713A5054981462 @default.
- W1591283713 hasAuthorship W1591283713A5064688195 @default.
- W1591283713 hasBestOaLocation W15912837131 @default.
- W1591283713 hasConcept C105702510 @default.
- W1591283713 hasConcept C141071460 @default.
- W1591283713 hasConcept C142724271 @default.
- W1591283713 hasConcept C178409289 @default.
- W1591283713 hasConcept C2777397368 @default.
- W1591283713 hasConcept C2780355897 @default.
- W1591283713 hasConcept C71924100 @default.
- W1591283713 hasConceptScore W1591283713C105702510 @default.
- W1591283713 hasConceptScore W1591283713C141071460 @default.
- W1591283713 hasConceptScore W1591283713C142724271 @default.
- W1591283713 hasConceptScore W1591283713C178409289 @default.
- W1591283713 hasConceptScore W1591283713C2777397368 @default.
- W1591283713 hasConceptScore W1591283713C2780355897 @default.
- W1591283713 hasConceptScore W1591283713C71924100 @default.
- W1591283713 hasIssue "1" @default.
- W1591283713 hasLocation W15912837131 @default.
- W1591283713 hasLocation W15912837132 @default.
- W1591283713 hasOpenAccess W1591283713 @default.
- W1591283713 hasPrimaryLocation W15912837131 @default.
- W1591283713 hasRelatedWork W2019803245 @default.
- W1591283713 hasRelatedWork W2049381901 @default.
- W1591283713 hasRelatedWork W2138169744 @default.
- W1591283713 hasRelatedWork W2250937972 @default.
- W1591283713 hasRelatedWork W2279574988 @default.
- W1591283713 hasRelatedWork W2316136877 @default.
- W1591283713 hasRelatedWork W2387965447 @default.
- W1591283713 hasRelatedWork W2388221226 @default.
- W1591283713 hasRelatedWork W2415476697 @default.
- W1591283713 hasRelatedWork W2185743999 @default.
- W1591283713 hasVolume "113" @default.
- W1591283713 isParatext "false" @default.
- W1591283713 isRetracted "false" @default.
- W1591283713 magId "1591283713" @default.
- W1591283713 workType "article" @default.