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- W1591298544 abstract "We describe the preparation and characterization of block liposomes, a new class of liquid (chain-melted) vesicles, from mixtures of the highly charged (+16 e) multivalent cationic lipid MVLBG2 and 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC). Block liposomes (BLs) consist of distinct spherical, tubular vesicles, and cylindrical micelles that remain connected, forming a single liposome. This is in contrast to typical liposome systems, where distinctly shaped liposomes are macroscopically separated. In a narrow composition range (8-10 mol% MVLBG2), an abundance of micrometer-scale BLs (typically sphere-tube-sphere triblocks) is observed. Cryo-TEM reveals that BLs are also present at the nanometer scale, where the blocks consist of distinctly shaped nanoscale spheres, pears, tubes, or rods. Pear-tube diblock and pear-tube-pear triblock liposomes contain nanotubes with inner lumen diameter 10-50 nm. In addition, sphere-rod diblock liposomes are present, containing rigid micellar nanorods approximately 4 nm in diameter and several microm in length. Block liposomes may find a range of applications in chemical and nucleic acid delivery and as building blocks in the design of templates for hierarchical structures." @default.
- W1591298544 created "2016-06-24" @default.
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- W1591298544 date "2009-01-01" @default.
- W1591298544 modified "2023-10-10" @default.
- W1591298544 title "Block Liposomes" @default.
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- W1591298544 doi "https://doi.org/10.1016/s0076-6879(09)65006-0" @default.
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