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- W159131497 abstract "This chapter discusses the pharmacology of GABA auto receptors. It describes the existence of GABA autoreceptors capable of exerting a negative feedback control on GABA release. The chapter describes a study to elucidate any pharmacological differences between the autoreceptors and classical postsynaptic GABA receptors by the potency of a number of known GABA agonists in inhibiting K+-stimulated GABA release and in inhibiting high affinity 3H-GABA binding in rat cortical synaptosomes. The order of potency of the GABA agonists muscimol, PSA, isoguvacine, THIP, and δ-ALA in inhibiting GABA release was the same as that for inhibition of 3H-GABA binding. There was also a good direct correlation between inhibition of GABA release and GABA receptor occupancy. This suggests that the autoreceptors are pharmacologically identical to the sites labeled with 3H-GABA in synaptic membranes. In addition, it appears that the autoreceptors are directly coupled to the effector mechanism without any spare receptors." @default.
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- W159131497 date "1980-01-01" @default.
- W159131497 modified "2023-09-23" @default.
- W159131497 title "PHARMACOLOGY OF GABA AUTORECEPTORS" @default.
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- W159131497 doi "https://doi.org/10.1016/b978-0-08-025921-5.50022-9" @default.
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