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- W1591350602 abstract "Abstract Experimental autoimmune orchitis (EAO) can be induced in vitro. Normal lymph node lymphocytes cultured with autologous dissociated testis cells form rosette-like aggregates and later undergo blast transformation and proliferation. These stimulated lymphocytes cause in vivo EAO lesions, when injected into syngeneic recipients. Moreover, their autoimmune reactivity can be monitored by an in vitro cytostasis assay. Density gradient analysis of the early lymphocyte-testis cultures reveals that the autoimmune reactive lymphocytes are enriched in the rosette populations. It therefore appears that testicular self-antigens are recognized by clonally preformed autologous lymphocytes." @default.
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- W1591350602 modified "2023-09-26" @default.
- W1591350602 title "Experimental Autoimmune Orchitis: in Vitro Induction of an Autoimmune Disease" @default.
- W1591350602 doi "https://doi.org/10.4049/jimmunol.116.1.159" @default.
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