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- W1591567166 abstract "We hypothesize that the inner medulla (IM) of Dipodomys merriami, a desert rodent that concentrates its urine to over 6000 mOsm/Kg water, provides extreme examples of architectural features most necessary for production of highly concentrated urine. Three-dimensional architecture of vasculature and nephron segments in the IM was assessed with digital reconstructions from physical tissue sections. Descending and ascending vasa recta (DVR, AVR), descending thin limbs (DTLs), ascending thin limbs (ATLs), and collecting ducts (CDs) were identified by indirect immunofluorescence using antibodies that label segment-specific proteins associated with solute and water transport and lectins (UT-B, wheat germ lectin, AQP1, ClC-K1, and AQP2, respectively). CD clusters form the central organizing motif in the IM. Transverse sections along the corticopapillary axis show nonuniform distribution of AQP-1-positive DTLs and uniform distribution of ATLs. Countercurrent exchange occurs only at the perimeter of CD clusters as DVR lie distant from CDs. Electron microscopy shows fenestrated AVR adhering to CDs. This architectural arrangement raises the possibility that fluid and solute reabsorbed from CDs diffuses preferentially into AVR. An additional factor increasing and defining axial compartmentation, and thereby restricting diffusive exchange, would be interstitial cell architecture. DK16294" @default.
- W1591567166 created "2016-06-24" @default.
- W1591567166 creator A5015795814 @default.
- W1591567166 date "2010-04-01" @default.
- W1591567166 modified "2023-09-27" @default.
- W1591567166 title "Three‐dimensional architecture of the renal inner medulla of the desert rodent Dipodomys merriami: potential impact on the urinary concentrating mechanism" @default.
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- W1591567166 doi "https://doi.org/10.1096/fasebj.24.1_supplement.813.18" @default.
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