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- W1591569090 abstract "The epidermis is the outermost skin layer and provides the first line of defence against the external environment. Keratinocytes are the most predominant cells in the epidermis and play a critical role in maintaining epidermal barrier function. When the barrier is disrupted any of a number of diseases, such as chronic wounds, psoriasis, pemphigus, atopic dermatitis or toxic epidermal necrolysis, can take hold. Activated protein C (APC) or its precursor, protein C, is abundantly expressed by skin epidermal keratinocytes and stimulates their proliferation and migration, and inhibits apoptosis and inflammation, leading to a healing phenotype. Importantly, APC also increases the barrier function of keratinocytes by promoting expression and cell-cell contact redistribution of tight junction proteins. These cytoprotective properties of APC on epidermal keratinocytes place it as an exciting new therapy for skin disorders associated with the disruption of barrier function and inflammation." @default.
- W1591569090 created "2016-06-24" @default.
- W1591569090 creator A5012952846 @default.
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- W1591569090 date "2015-01-01" @default.
- W1591569090 modified "2023-10-16" @default.
- W1591569090 title "Novel Functions of the Anticoagulant Activated Protein C in Maintaining Skin Barrier Integrity to Impact on Skin Disease" @default.
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- W1591569090 cites W1984849676 @default.
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- W1591569090 doi "https://doi.org/10.1159/000430957" @default.
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