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- W1591635462 abstract "Background: Aneurysmal subarachnoid hemorrhage has high morbidity and mortality. The incidence of unruptured cerebral aneurysms has been estimated to be much higher and up to 4[percnt] in general population. The pathogenesis of cerebral aneurysm formation has been discussed in the past but the exact molecular mechanisms are still to be elucidated.Alpha-1 antitrypsin is a potent protease inhibitor and its deficiency has been implicated in pathogenesis of emphysema and liver cirrhosis, however; its role in aneurysm formation is debatable.Design/Methods: We measured serum levels of alpha-1 antitrypsin, alpha-1 antichemotrypsin and alpha-2 macroglobulin in 82 patients with cerebral aneurysms who were admitted to a single institution from 2006 to 2013. Genomic sequencing from those patients was also performed. Clinical characteristics and demographic data were obtained from our electronic medical record data base.Results: The serum alpha-1 antitrypsin level was less than 1mg/ml in 8 patients (9.7[percnt]) and less than 1.5 mg/ml in 32 patients (39[percnt]). The normal values were considered 1.5 to 3.5 mg/ml. The serum level of 1 to 1.5mg/ml was defined as low normal or borderline. A serum level of less than 1.5 mg/ml has been estimated to be seen in about 7[percnt] in normal population which is significantly lower than our aneurysm cases (39[percnt]).Conclusion: A low serum level of alpha-1 antitrypsin is a potential risk factor for cerebral aneurysm formation. This supports the theory of protease-antiprotease imbalance in pathogenesis of cerebral aneurysm formation. Disclosure: Dr. Mahta has nothing to disclose. Dr. Weaver has nothing to disclose. Dr. Kueppers has nothing to disclose." @default.
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- W1591635462 date "2015-04-06" @default.
- W1591635462 modified "2023-09-23" @default.
- W1591635462 title "Alpha-1 Antitrypsin Deficiency in Cerebral Aneurysms (P3.109)" @default.
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