Matches in SemOpenAlex for { <https://semopenalex.org/work/W1591657425> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1591657425 endingPage "694" @default.
- W1591657425 startingPage "688" @default.
- W1591657425 abstract "Summary The effects of thyroxine on the incorporation of glycine-1-C14 into ribonucleic acid (RNA), deoxyribonucleic acid (DNA), acid-soluble purines, and protein were compared in nine thyroxine-inhibitable (“dependent”) and twelve autonomous thyrotropic pituitary tumors in LAF1 mice. Orotic acid-6-C14 was given to all mice prior to thyroxine (or control) treatment, to provide, in the case of RNA and DNA, an index of the effect of thyroxine less variable than glycine incorporation alone; viz., the ratio incorporation of glycine into purines/incorporation of orotic acid into pyrimidines (RSA purines/RSA pyrimidines). In dependent tumors, thyroxine treatment was associated with a significant reduction in this ratio—56 per cent in the case of RNA and 35 per cent in the case of DNA. This apparent inhibition of nucleic acid synthesis may reflect at least in part an inhibition of purine synthesis, since thyroxine treatment was associated with a 51 per cent reduction in the incorporation of glycine into acid-soluble purines in one of two subpassages of the dependent tumor strain studied. Incorporation of glycine into protein was not demonstrably affected in these short-term experiments. In autonomous tumors, thyroxine did not demonstrably affect RNA, DNA, purine, or protein synthesis, as measured by incorporation of glycine, or by the ratio RSA purines/RSA pyrimidines. It appears that the acquisition of autonomy by mouse thyrotropic tumors is associated with a loss of susceptibility of nucleic acid synthesis to inhibition by thyroxine." @default.
- W1591657425 created "2016-06-24" @default.
- W1591657425 creator A5020572749 @default.
- W1591657425 creator A5062744960 @default.
- W1591657425 date "1963-06-01" @default.
- W1591657425 modified "2023-09-23" @default.
- W1591657425 title "The Effects of Thyroxine on Nucleic Acid and Protein Metabolism in Mouse Thyrotropic Pituitary Tumors" @default.
- W1591657425 cites W1981639031 @default.
- W1591657425 cites W2186323258 @default.
- W1591657425 cites W2327712847 @default.
- W1591657425 hasPublicationYear "1963" @default.
- W1591657425 type Work @default.
- W1591657425 sameAs 1591657425 @default.
- W1591657425 citedByCount "1" @default.
- W1591657425 crossrefType "journal-article" @default.
- W1591657425 hasAuthorship W1591657425A5020572749 @default.
- W1591657425 hasAuthorship W1591657425A5062744960 @default.
- W1591657425 hasConcept C104317684 @default.
- W1591657425 hasConcept C126322002 @default.
- W1591657425 hasConcept C134018914 @default.
- W1591657425 hasConcept C169586020 @default.
- W1591657425 hasConcept C181199279 @default.
- W1591657425 hasConcept C185592680 @default.
- W1591657425 hasConcept C24107716 @default.
- W1591657425 hasConcept C2775851010 @default.
- W1591657425 hasConcept C2776476023 @default.
- W1591657425 hasConcept C2777756961 @default.
- W1591657425 hasConcept C515207424 @default.
- W1591657425 hasConcept C526584372 @default.
- W1591657425 hasConcept C552990157 @default.
- W1591657425 hasConcept C55493867 @default.
- W1591657425 hasConcept C62231903 @default.
- W1591657425 hasConcept C64241487 @default.
- W1591657425 hasConcept C67705224 @default.
- W1591657425 hasConcept C71924100 @default.
- W1591657425 hasConcept C86803240 @default.
- W1591657425 hasConceptScore W1591657425C104317684 @default.
- W1591657425 hasConceptScore W1591657425C126322002 @default.
- W1591657425 hasConceptScore W1591657425C134018914 @default.
- W1591657425 hasConceptScore W1591657425C169586020 @default.
- W1591657425 hasConceptScore W1591657425C181199279 @default.
- W1591657425 hasConceptScore W1591657425C185592680 @default.
- W1591657425 hasConceptScore W1591657425C24107716 @default.
- W1591657425 hasConceptScore W1591657425C2775851010 @default.
- W1591657425 hasConceptScore W1591657425C2776476023 @default.
- W1591657425 hasConceptScore W1591657425C2777756961 @default.
- W1591657425 hasConceptScore W1591657425C515207424 @default.
- W1591657425 hasConceptScore W1591657425C526584372 @default.
- W1591657425 hasConceptScore W1591657425C552990157 @default.
- W1591657425 hasConceptScore W1591657425C55493867 @default.
- W1591657425 hasConceptScore W1591657425C62231903 @default.
- W1591657425 hasConceptScore W1591657425C64241487 @default.
- W1591657425 hasConceptScore W1591657425C67705224 @default.
- W1591657425 hasConceptScore W1591657425C71924100 @default.
- W1591657425 hasConceptScore W1591657425C86803240 @default.
- W1591657425 hasIssue "5" @default.
- W1591657425 hasLocation W15916574251 @default.
- W1591657425 hasOpenAccess W1591657425 @default.
- W1591657425 hasPrimaryLocation W15916574251 @default.
- W1591657425 hasRelatedWork W1504596048 @default.
- W1591657425 hasRelatedWork W1505310296 @default.
- W1591657425 hasRelatedWork W1511280675 @default.
- W1591657425 hasRelatedWork W1542279817 @default.
- W1591657425 hasRelatedWork W1574797450 @default.
- W1591657425 hasRelatedWork W1970016951 @default.
- W1591657425 hasRelatedWork W1982414047 @default.
- W1591657425 hasRelatedWork W2003006067 @default.
- W1591657425 hasRelatedWork W2004555753 @default.
- W1591657425 hasRelatedWork W2028413650 @default.
- W1591657425 hasRelatedWork W2028523829 @default.
- W1591657425 hasRelatedWork W2032148253 @default.
- W1591657425 hasRelatedWork W2050447583 @default.
- W1591657425 hasRelatedWork W2076861235 @default.
- W1591657425 hasRelatedWork W2095452460 @default.
- W1591657425 hasRelatedWork W2105107433 @default.
- W1591657425 hasRelatedWork W2106262952 @default.
- W1591657425 hasRelatedWork W2411529683 @default.
- W1591657425 hasRelatedWork W2440925842 @default.
- W1591657425 hasRelatedWork W85886883 @default.
- W1591657425 hasVolume "23" @default.
- W1591657425 isParatext "false" @default.
- W1591657425 isRetracted "false" @default.
- W1591657425 magId "1591657425" @default.
- W1591657425 workType "article" @default.