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- W1591706403 abstract "Diabetic nephropathy (DN) is a common complication of diabetes mellitus with multifactorial etiology. Genetic factors independently account for disease risk variability. Unraveling these genetic factors has the potential of gaining mechanistic insights needed to develop novel preventive and therapeutic strategies. Family studies have not yet identified genetic loci unequivocally linked to DN. Genome-wide association studies (GWAS) systematically analyze several million genetic variants distributed across the whole genome, thus capturing most of the individual's total genetic variation and potentially allowing the identification of genetic variants associated with common diseases. Large-scale GWAS are now under way for the identification of loci associated with DN. Challenges include adequately sized cohorts, uniform phenotype definition, and statistical models of gene-environment and gene-gene interactions. This chapter provides an overview of genetic approaches and methods, recent results of genetic studies of DN, and strategies of translating genetic findings into clinical use." @default.
- W1591706403 created "2016-06-24" @default.
- W1591706403 creator A5050024715 @default.
- W1591706403 creator A5078613225 @default.
- W1591706403 date "2012-12-17" @default.
- W1591706403 modified "2023-09-25" @default.
- W1591706403 title "Genetic Risk Factors for Diabetic Nephropathy" @default.
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- W1591706403 cites W1970394435 @default.
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- W1591706403 cites W1989368862 @default.
- W1591706403 cites W1989761997 @default.
- W1591706403 cites W1991595901 @default.
- W1591706403 cites W1993630574 @default.
- W1591706403 cites W1998609229 @default.
- W1591706403 cites W1999611318 @default.
- W1591706403 cites W2003510810 @default.
- W1591706403 cites W2004437896 @default.
- W1591706403 cites W2014526476 @default.
- W1591706403 cites W2023362855 @default.
- W1591706403 cites W2033391106 @default.
- W1591706403 cites W2035485618 @default.
- W1591706403 cites W2041467022 @default.
- W1591706403 cites W2048740425 @default.
- W1591706403 cites W2051610146 @default.
- W1591706403 cites W2051679072 @default.
- W1591706403 cites W2052362972 @default.
- W1591706403 cites W2053233405 @default.
- W1591706403 cites W2056866499 @default.
- W1591706403 cites W2057292957 @default.
- W1591706403 cites W2059346848 @default.
- W1591706403 cites W2069246794 @default.
- W1591706403 cites W2071257068 @default.
- W1591706403 cites W2071481601 @default.
- W1591706403 cites W2071894938 @default.
- W1591706403 cites W2079017561 @default.
- W1591706403 cites W2083728668 @default.
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- W1591706403 cites W2108525019 @default.
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- W1591706403 doi "https://doi.org/10.1002/9781118494073.ch3" @default.
- W1591706403 hasPublicationYear "2012" @default.
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