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- W1591781313 abstract "1. Pig red cells do not glycolyze in vitro, even though the necessary enzymes can be demonstrated in hemolysates. Although ATP levels are adequate, the cell has a very low permeability to glucose. During an 8-h incubation, ATP (2.58 ± 0.06 μM/ml erythrocytes) decreases by 50% whether glucose is present or not. 2. Amphotericin B, a polyene antibiotic which interacts with membrane sterols, induces glycolysis in these cells. This is associated with an increase in permeability to glucose as well as sodium and potassium. 3. ATP falls rapidly in the presence of amphotericin B. Part of this can be shown to be dependent on an increase of cell sodium with a concomitant stimulation of active transport. ATP is spared if the incubation is carried out in a medium of the same ionic composition as the cells, or if ouabain is added along with amphotericin B. 4. The metabolic effects of amphotericin B are not specific for glucose. The cells can also form lactate from other common hexoses (mannose, fructose, galactose) when treated with the drug. 5. It is concluded that pig cells have a capacity for significant glycolytic activity which is normally limited by their low permeability to glucose. Once an effective substrate gains admission to the cell, glycolysis ensues. If measures are taken to spare ATP, it can be readily shown that this glycolis contributes to the maintenance of energy stores. 6. The substrate used by these cells for energy metabolism in vivo remains unknown. Analysis of plasma reveals to be the only sugar present in any detectable amount." @default.
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- W1591781313 date "1971-01-01" @default.
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- W1591781313 title "Studies on the energy metabolism of pig red cells" @default.
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- W1591781313 doi "https://doi.org/10.1016/0304-4165(71)90048-1" @default.
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