FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1591799043> ?p ?o ?g. }

• W1591799043 abstract "Plants possess multiple mechanisms to detect pathogen attack and protect themselves against colonisation. The antagonistic interplay of positive and negative regulators allows the plant to spacially and temporarily control defence responses. EDS1 (Enhanced Disease Susceptibility1) and PAD4 (Phytoalexin Deficient4) encode lipase-like proteins that positively regulate plant basal resistance to virulent pathogens. Additionally, EDS1 and PAD4 are recruited by resistance (R) genes of the TIR-NBS-LRR but not of the CC-NBS-LRR type in R gene-mediated resistance. Previous experiments demonstrated that EDS1 and PAD4 are required for accumulation of salicylic acid (SA), a phenolic signal in defence to biotrophic pathogens. Recent findings suggest that EDS1 and PAD4 promote defence also independently of SA. This as yet uncharacterised EDS1/PAD4-controlled pathway is important for full expression of local R gene-triggered and basal resistance as well as for systemic immunity. To identify components involved specifically in EDS1/PAD4-controlled signalling, transcriptional profiles of Arabidopsis thaliana wild-type, eds1 and pad4 mutant plants were examined during early R gene-mediated defence using whole-genome oligonucleotide microarrays. In wild-type, the inoculation with strains of the bacterial plant pathogen, Pseudomonas syringae pv. tomato, expressing either avrRpm1 (avr1; recognised by a CC-NBS-LRR-type R protein) or avrRps4 (avr4; recognised by a TIR-NBS-LRR-type R protein) triggered transcriptional changes in a similar set of genes but with different kinetics. Sets of genes with EDS1- and PAD4-dependent expression in healthy, avr1- or avr4-challenged leaves were identified. For a subset of these genes, corresponding insertional mutants were isolated and tested for alterations in pathogen resistance. The mutant screen resulted in the identification of a flavin-dependent monooxygenase (FMO) as a positive regulator and two sequence-related NUDIX (nucleoside diphosphates linked to some other moiety x) hydrolases as negative regulators of plant disease resistance. This study demonstrates for the first time that FMOs and NUDIX hydrolases can modulate host defence responses against pathogens in any biological system. The findings presented here support the view that EDS1 and PAD4 control the expression of both positive and negative regulators as a mean to fine-tune plant immune responses." @default.
• W1591799043 created "2016-06-24" @default.
• W1591799043 creator A5070516437 @default.
• W1591799043 date "2005-01-01" @default.
• W1591799043 modified "2023-09-27" @default.
• W1591799043 title "Gene expression profiling leading to identification of essential components in EDS1/PAD4-regulated plant defence" @default.
• W1591799043 cites W1493767453 @default.
• W1591799043 cites W1494075612 @default.
• W1591799043 cites W1519633296 @default.
• W1591799043 cites W1537218374 @default.
• W1591799043 cites W1599207401 @default.
• W1591799043 cites W1599420452 @default.
• W1591799043 cites W1616931779 @default.
• W1591799043 cites W1778452749 @default.
• W1591799043 cites W1825673299 @default.
• W1591799043 cites W1826812957 @default.
• W1591799043 cites W1867568172 @default.
• W1591799043 cites W1899198141 @default.
• W1591799043 cites W1932988598 @default.
• W1591799043 cites W1942665378 @default.
• W1591799043 cites W1951338172 @default.
• W1591799043 cites W1967479392 @default.
• W1591799043 cites W1968237005 @default.
• W1591799043 cites W1968829263 @default.
• W1591799043 cites W1971005452 @default.
• W1591799043 cites W1973328229 @default.
• W1591799043 cites W1973976863 @default.
• W1591799043 cites W1982335518 @default.
• W1591799043 cites W1982819308 @default.
• W1591799043 cites W1989046023 @default.
• W1591799043 cites W1990511407 @default.
• W1591799043 cites W1991070995 @default.
• W1591799043 cites W1992540955 @default.
• W1591799043 cites W1993130226 @default.
• W1591799043 cites W1993972255 @default.
• W1591799043 cites W1995444885 @default.
• W1591799043 cites W1997980474 @default.
• W1591799043 cites W1999240000 @default.
• W1591799043 cites W1999653220 @default.
• W1591799043 cites W2000938033 @default.
• W1591799043 cites W2002225831 @default.
• W1591799043 cites W2003230661 @default.
• W1591799043 cites W2003377214 @default.
• W1591799043 cites W2003412276 @default.
• W1591799043 cites W2003574191 @default.
• W1591799043 cites W2007358741 @default.
• W1591799043 cites W2008265347 @default.
• W1591799043 cites W2008611226 @default.
• W1591799043 cites W2008932182 @default.
• W1591799043 cites W2011804819 @default.
• W1591799043 cites W2012650641 @default.
• W1591799043 cites W2016032876 @default.
• W1591799043 cites W2018159164 @default.
• W1591799043 cites W2021521164 @default.
• W1591799043 cites W2022738681 @default.
• W1591799043 cites W2023794902 @default.
• W1591799043 cites W2023796149 @default.
• W1591799043 cites W2023821254 @default.
• W1591799043 cites W2024012002 @default.
• W1591799043 cites W2024493338 @default.
• W1591799043 cites W2026238074 @default.
• W1591799043 cites W2027224416 @default.
• W1591799043 cites W2032072281 @default.
• W1591799043 cites W2034872747 @default.
• W1591799043 cites W2034940828 @default.
• W1591799043 cites W2035491291 @default.
• W1591799043 cites W2036529190 @default.
• W1591799043 cites W2039268793 @default.
• W1591799043 cites W2043420088 @default.
• W1591799043 cites W2043421474 @default.
• W1591799043 cites W2044942147 @default.
• W1591799043 cites W2046385971 @default.
• W1591799043 cites W2046618236 @default.
• W1591799043 cites W2049151809 @default.
• W1591799043 cites W2049421907 @default.
• W1591799043 cites W2052929422 @default.
• W1591799043 cites W2053209482 @default.
• W1591799043 cites W2055323344 @default.
• W1591799043 cites W2055582735 @default.
• W1591799043 cites W2058931687 @default.
• W1591799043 cites W2059971395 @default.
• W1591799043 cites W2063224690 @default.
• W1591799043 cites W2063358218 @default.
• W1591799043 cites W2064301051 @default.
• W1591799043 cites W2064744932 @default.
• W1591799043 cites W2065941710 @default.
• W1591799043 cites W2066394121 @default.
• W1591799043 cites W2066816955 @default.
• W1591799043 cites W2069579071 @default.
• W1591799043 cites W2069585385 @default.
• W1591799043 cites W2071041070 @default.
• W1591799043 cites W2071097210 @default.
• W1591799043 cites W2072242652 @default.
• W1591799043 cites W2073181394 @default.
• W1591799043 cites W2073376866 @default.
• W1591799043 cites W2073872036 @default.
• W1591799043 cites W2074512572 @default.
• W1591799043 cites W2074773204 @default.
• W1591799043 cites W2075772916 @default.
• W1591799043 cites W2077200333 @default.

• next