Matches in SemOpenAlex for { <https://semopenalex.org/work/W1592176024> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W1592176024 endingPage "9" @default.
- W1592176024 startingPage "55" @default.
- W1592176024 abstract "The palatine tonsils, and particularly the nasopharyngeal tonsil (adenoid), may be functionally comparable to nasal-associated lymphoid tissue in rodents. Primary follicles occur in human tonsils at 16 weeks' gestation, and formation of germinal centres (GC) takes place shortly after birth. The GC arise in T-cell-dependent B-cell responses and are associated with: i) clonal expansion; ii) somatic hypermutation in immunoglobulin variable (Ig V)-region genes; iii) positive selection of B cells based on affinity for antigen; iv) differentiation to memory B cells and plasma cells; and v) induction of the J-chain gene. The follicular dendritic cells (FDC) of GC retain native antigen which stimulates growth of B-cell blasts and hypermutation of their Ig V genes. The resulting centrocytes die by apoptosis unless they are selected by antigen. Cognate interaction between CD4+ helper T cells and B cells is important to promote downstream switching of the heavy chain constant (CH) genes. In human tonsillar GC this process normally gives rise mainly to IgG (55%-72%) and IgA (13%-18%) immunocytes, both isotypes normally being partially associated with J-chain expression (36% and 29%, respectively). Because J chain is a key peptide in secretory IgA, tonsillar GC may contribute precursor cells to mucosal effector sites. Thus, mucosal immunity can be induced in the airways by nasal immunization, and the level of nasopharyngeal and salivary secretory IgA is decreased after adenotonsillectomy." @default.
- W1592176024 created "2016-06-24" @default.
- W1592176024 creator A5042575652 @default.
- W1592176024 date "1996-01-01" @default.
- W1592176024 modified "2023-09-23" @default.
- W1592176024 title "The B-cell development in tonsillar lymphoid follicles." @default.
- W1592176024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9082810" @default.
- W1592176024 hasPublicationYear "1996" @default.
- W1592176024 type Work @default.
- W1592176024 sameAs 1592176024 @default.
- W1592176024 citedByCount "18" @default.
- W1592176024 countsByYear W15921760242014 @default.
- W1592176024 countsByYear W15921760242015 @default.
- W1592176024 countsByYear W15921760242016 @default.
- W1592176024 countsByYear W15921760242017 @default.
- W1592176024 countsByYear W15921760242022 @default.
- W1592176024 crossrefType "journal-article" @default.
- W1592176024 hasAuthorship W1592176024A5042575652 @default.
- W1592176024 hasConcept C128526571 @default.
- W1592176024 hasConcept C137756551 @default.
- W1592176024 hasConcept C147483822 @default.
- W1592176024 hasConcept C153911025 @default.
- W1592176024 hasConcept C159654299 @default.
- W1592176024 hasConcept C203014093 @default.
- W1592176024 hasConcept C2776444015 @default.
- W1592176024 hasConcept C2778453870 @default.
- W1592176024 hasConcept C2779419017 @default.
- W1592176024 hasConcept C2781163425 @default.
- W1592176024 hasConcept C86803240 @default.
- W1592176024 hasConcept C96926380 @default.
- W1592176024 hasConceptScore W1592176024C128526571 @default.
- W1592176024 hasConceptScore W1592176024C137756551 @default.
- W1592176024 hasConceptScore W1592176024C147483822 @default.
- W1592176024 hasConceptScore W1592176024C153911025 @default.
- W1592176024 hasConceptScore W1592176024C159654299 @default.
- W1592176024 hasConceptScore W1592176024C203014093 @default.
- W1592176024 hasConceptScore W1592176024C2776444015 @default.
- W1592176024 hasConceptScore W1592176024C2778453870 @default.
- W1592176024 hasConceptScore W1592176024C2779419017 @default.
- W1592176024 hasConceptScore W1592176024C2781163425 @default.
- W1592176024 hasConceptScore W1592176024C86803240 @default.
- W1592176024 hasConceptScore W1592176024C96926380 @default.
- W1592176024 hasLocation W15921760241 @default.
- W1592176024 hasOpenAccess W1592176024 @default.
- W1592176024 hasPrimaryLocation W15921760241 @default.
- W1592176024 hasRelatedWork W1540907561 @default.
- W1592176024 hasRelatedWork W1592176024 @default.
- W1592176024 hasRelatedWork W1837294723 @default.
- W1592176024 hasRelatedWork W2048365604 @default.
- W1592176024 hasRelatedWork W2075634030 @default.
- W1592176024 hasRelatedWork W2088870397 @default.
- W1592176024 hasRelatedWork W2103735815 @default.
- W1592176024 hasRelatedWork W2160762238 @default.
- W1592176024 hasRelatedWork W2409393912 @default.
- W1592176024 hasRelatedWork W4200628384 @default.
- W1592176024 hasVolume "523" @default.
- W1592176024 isParatext "false" @default.
- W1592176024 isRetracted "false" @default.
- W1592176024 magId "1592176024" @default.
- W1592176024 workType "article" @default.