Matches in SemOpenAlex for { <https://semopenalex.org/work/W1592257029> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1592257029 endingPage "4673" @default.
- W1592257029 startingPage "4669" @default.
- W1592257029 abstract "Abstract Results of studies in mice and clinical observations in man indicate that T cell-mediated immunity is important in resistance to herpes simplex virus (HSV) infections. This study was undertaken to elucidate the viral antigen specificity of human HSV-immune T cells. Purified HSV-1 glycoproteins gB-1 and gD-1, cloned and expressed in mammalian cells, were found to stimulate proliferation of, and interleukin 2 (IL 2) production by, peripheral blood lymphocytes (PBL) of HSV seropositive individuals, indicating the presence of memory T cells to gB-1 and gD-1 in individuals with serologic evidence of immunity to HSV. Second, T cell clones, generated by stimulation of PBL with HSV-1, were found to recognize gB-1 or gD-1, as evidenced by the ability of the clones to proliferate in response to stimulation with gB-1 or gD-1 in the absence of exogenous IL 2. Third, HSV-specific T cell clones, lytic for HSV-1 or both HSV-1- and HSV-2-infected autologous target cells, were generated after stimulation of PBL with purified cloned gB-1 or gD-1. Our findings, that human HSV-specific T cells can recognize and be activated by HSV subunit antigens gB-1 or gD-1, imply that these glycoproteins play a role in human T cell-mediated immunity to HSV and support the contention that a gB-1 or gD-1 subunit vaccine may be protective in man." @default.
- W1592257029 created "2016-06-24" @default.
- W1592257029 creator A5022078108 @default.
- W1592257029 creator A5025663305 @default.
- W1592257029 creator A5049126409 @default.
- W1592257029 creator A5070931112 @default.
- W1592257029 creator A5084373930 @default.
- W1592257029 creator A5090225287 @default.
- W1592257029 date "1986-06-15" @default.
- W1592257029 modified "2023-10-17" @default.
- W1592257029 title "Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. IV. Recognition and activation by cloned glycoproteins gB and gD." @default.
- W1592257029 doi "https://doi.org/10.4049/jimmunol.136.12.4669" @default.
- W1592257029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2423598" @default.
- W1592257029 hasPublicationYear "1986" @default.
- W1592257029 type Work @default.
- W1592257029 sameAs 1592257029 @default.
- W1592257029 citedByCount "86" @default.
- W1592257029 countsByYear W15922570292012 @default.
- W1592257029 countsByYear W15922570292013 @default.
- W1592257029 countsByYear W15922570292015 @default.
- W1592257029 countsByYear W15922570292018 @default.
- W1592257029 countsByYear W15922570292019 @default.
- W1592257029 countsByYear W15922570292023 @default.
- W1592257029 crossrefType "journal-article" @default.
- W1592257029 hasAuthorship W1592257029A5022078108 @default.
- W1592257029 hasAuthorship W1592257029A5025663305 @default.
- W1592257029 hasAuthorship W1592257029A5049126409 @default.
- W1592257029 hasAuthorship W1592257029A5070931112 @default.
- W1592257029 hasAuthorship W1592257029A5084373930 @default.
- W1592257029 hasAuthorship W1592257029A5090225287 @default.
- W1592257029 hasBestOaLocation W15922570291 @default.
- W1592257029 hasConcept C108625454 @default.
- W1592257029 hasConcept C147483822 @default.
- W1592257029 hasConcept C153911025 @default.
- W1592257029 hasConcept C154317977 @default.
- W1592257029 hasConcept C159047783 @default.
- W1592257029 hasConcept C182615771 @default.
- W1592257029 hasConcept C202751555 @default.
- W1592257029 hasConcept C203014093 @default.
- W1592257029 hasConcept C2522874641 @default.
- W1592257029 hasConcept C2776090121 @default.
- W1592257029 hasConcept C2779341262 @default.
- W1592257029 hasConcept C2781196997 @default.
- W1592257029 hasConcept C3017875465 @default.
- W1592257029 hasConcept C36372059 @default.
- W1592257029 hasConcept C55493867 @default.
- W1592257029 hasConcept C86803240 @default.
- W1592257029 hasConcept C8891405 @default.
- W1592257029 hasConceptScore W1592257029C108625454 @default.
- W1592257029 hasConceptScore W1592257029C147483822 @default.
- W1592257029 hasConceptScore W1592257029C153911025 @default.
- W1592257029 hasConceptScore W1592257029C154317977 @default.
- W1592257029 hasConceptScore W1592257029C159047783 @default.
- W1592257029 hasConceptScore W1592257029C182615771 @default.
- W1592257029 hasConceptScore W1592257029C202751555 @default.
- W1592257029 hasConceptScore W1592257029C203014093 @default.
- W1592257029 hasConceptScore W1592257029C2522874641 @default.
- W1592257029 hasConceptScore W1592257029C2776090121 @default.
- W1592257029 hasConceptScore W1592257029C2779341262 @default.
- W1592257029 hasConceptScore W1592257029C2781196997 @default.
- W1592257029 hasConceptScore W1592257029C3017875465 @default.
- W1592257029 hasConceptScore W1592257029C36372059 @default.
- W1592257029 hasConceptScore W1592257029C55493867 @default.
- W1592257029 hasConceptScore W1592257029C86803240 @default.
- W1592257029 hasConceptScore W1592257029C8891405 @default.
- W1592257029 hasIssue "12" @default.
- W1592257029 hasLocation W15922570291 @default.
- W1592257029 hasLocation W15922570292 @default.
- W1592257029 hasOpenAccess W1592257029 @default.
- W1592257029 hasPrimaryLocation W15922570291 @default.
- W1592257029 hasRelatedWork W1570882162 @default.
- W1592257029 hasRelatedWork W1592257029 @default.
- W1592257029 hasRelatedWork W1861344368 @default.
- W1592257029 hasRelatedWork W1979414005 @default.
- W1592257029 hasRelatedWork W2001055320 @default.
- W1592257029 hasRelatedWork W2027622304 @default.
- W1592257029 hasRelatedWork W2108065516 @default.
- W1592257029 hasRelatedWork W2220102944 @default.
- W1592257029 hasRelatedWork W2339159816 @default.
- W1592257029 hasRelatedWork W2430077013 @default.
- W1592257029 hasVolume "136" @default.
- W1592257029 isParatext "false" @default.
- W1592257029 isRetracted "false" @default.
- W1592257029 magId "1592257029" @default.
- W1592257029 workType "article" @default.