Matches in SemOpenAlex for { <https://semopenalex.org/work/W1592345947> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1592345947 endingPage "4" @default.
- W1592345947 startingPage "552" @default.
- W1592345947 abstract "Amoxycillin was administered to six dogs intravenously (as the sodium salt at 20 mg/kg bodyweight) and orally (as the trihydrate at 20 mg/kg). The oral treatments followed a Latin square pattern, each dog receiving amoxycillin as a 60 ml suspension by stomach tube, or as 3 ml of drops or in the form of tablets. The concentration of the drug in the plasma was measured microbiologically and its pharmacokinetic parameters were calculated by the use of statistical moments. After intravenous administration the mean +/- sd apparent volume of distribution was 0.312 +/- 0.102 litre/kg, the steady state rate of clearance was 3.4 +/- 1.1 ml/min/kg and the mean residence time was 1.6 +/- 0.4 hours. After oral administration the liquid forms of the drug tended to be more readily absorbed than the tablets, as indicated by their higher bioavailabilities (suspension 76.8 +/- 16.7 per cent, drops 68.2 +/- 25.8 per cent, tablets 64.2 +/- 17.9 per cent). However, the differences between their pharmacokinetic parameters were not statistically significant. The respective values of Cmax for the tablets, drops and suspension were 18.6 +/- 5.3 micrograms/ml, 18.1 +/- 2.4 micrograms/ml and 20.7 +/- 2.2 micrograms/ml, of tmax 2.0 +/- 1.0 hours, 1.4 +/- 0.6 hours and 1.4 +/- 0.5 hours and of the AUC 69.5 +/- 22.5 micrograms/ml hours, 71.8 +/- 21.0 micrograms/ml hours and 80.6 +/- 21.8 micrograms/ml hours. The two useful drug products (drops and tablets) had similar pharmacokinetic profiles in the dogs and can therefore be regarded as equivalent in this species." @default.
- W1592345947 created "2016-06-24" @default.
- W1592345947 creator A5034487950 @default.
- W1592345947 creator A5088839925 @default.
- W1592345947 date "1994-12-03" @default.
- W1592345947 modified "2023-10-14" @default.
- W1592345947 title "Bioavailability of different forms of amoxycillin administered orally to dogs." @default.
- W1592345947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7886889" @default.
- W1592345947 hasPublicationYear "1994" @default.
- W1592345947 type Work @default.
- W1592345947 sameAs 1592345947 @default.
- W1592345947 citedByCount "9" @default.
- W1592345947 countsByYear W15923459472012 @default.
- W1592345947 countsByYear W15923459472014 @default.
- W1592345947 countsByYear W15923459472015 @default.
- W1592345947 countsByYear W15923459472016 @default.
- W1592345947 countsByYear W15923459472018 @default.
- W1592345947 crossrefType "journal-article" @default.
- W1592345947 hasAuthorship W1592345947A5034487950 @default.
- W1592345947 hasAuthorship W1592345947A5088839925 @default.
- W1592345947 hasConcept C100544194 @default.
- W1592345947 hasConcept C112705442 @default.
- W1592345947 hasConcept C126322002 @default.
- W1592345947 hasConcept C139254425 @default.
- W1592345947 hasConcept C140793950 @default.
- W1592345947 hasConcept C158887663 @default.
- W1592345947 hasConcept C176674119 @default.
- W1592345947 hasConcept C181389837 @default.
- W1592345947 hasConcept C185592680 @default.
- W1592345947 hasConcept C22979827 @default.
- W1592345947 hasConcept C2777056448 @default.
- W1592345947 hasConcept C31903555 @default.
- W1592345947 hasConcept C70262065 @default.
- W1592345947 hasConcept C71924100 @default.
- W1592345947 hasConcept C77281830 @default.
- W1592345947 hasConcept C86803240 @default.
- W1592345947 hasConcept C98274493 @default.
- W1592345947 hasConceptScore W1592345947C100544194 @default.
- W1592345947 hasConceptScore W1592345947C112705442 @default.
- W1592345947 hasConceptScore W1592345947C126322002 @default.
- W1592345947 hasConceptScore W1592345947C139254425 @default.
- W1592345947 hasConceptScore W1592345947C140793950 @default.
- W1592345947 hasConceptScore W1592345947C158887663 @default.
- W1592345947 hasConceptScore W1592345947C176674119 @default.
- W1592345947 hasConceptScore W1592345947C181389837 @default.
- W1592345947 hasConceptScore W1592345947C185592680 @default.
- W1592345947 hasConceptScore W1592345947C22979827 @default.
- W1592345947 hasConceptScore W1592345947C2777056448 @default.
- W1592345947 hasConceptScore W1592345947C31903555 @default.
- W1592345947 hasConceptScore W1592345947C70262065 @default.
- W1592345947 hasConceptScore W1592345947C71924100 @default.
- W1592345947 hasConceptScore W1592345947C77281830 @default.
- W1592345947 hasConceptScore W1592345947C86803240 @default.
- W1592345947 hasConceptScore W1592345947C98274493 @default.
- W1592345947 hasIssue "23" @default.
- W1592345947 hasLocation W15923459471 @default.
- W1592345947 hasOpenAccess W1592345947 @default.
- W1592345947 hasPrimaryLocation W15923459471 @default.
- W1592345947 hasRelatedWork W1592345947 @default.
- W1592345947 hasRelatedWork W1773267112 @default.
- W1592345947 hasRelatedWork W1975321157 @default.
- W1592345947 hasRelatedWork W2012399333 @default.
- W1592345947 hasRelatedWork W2020497888 @default.
- W1592345947 hasRelatedWork W2026309482 @default.
- W1592345947 hasRelatedWork W2063402728 @default.
- W1592345947 hasRelatedWork W2069936009 @default.
- W1592345947 hasRelatedWork W2075612064 @default.
- W1592345947 hasRelatedWork W2080955156 @default.
- W1592345947 hasVolume "135" @default.
- W1592345947 isParatext "false" @default.
- W1592345947 isRetracted "false" @default.
- W1592345947 magId "1592345947" @default.
- W1592345947 workType "article" @default.