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- W1592386291 abstract "Abstract Phage, in which 60% or more of the DNA-thymidine was replaced with 5-iodo-2'-deoxyuridine (IUdR), were evaluated for their ability to induce phage-specific enzymes in Escherichia coli cultured in a medium not containing IUdR. The IUdR-substituted phage were unable to induce normal levels of activity of 5'-deoxycytidylate hydroxymethylase and lysozyme. Further, the appearance of these enzymic activities was delayed relative to that observed with normal phage. Dihydrofolate reductase activity followed a similar pattern. Other experiments showed that the effects observed were not caused by either poor adsorption of the phage or faulty injection of the phage DNA. In addition, the normal fluorescent lighting conditions of the laboratory did not affect the levels of enzymes induced by the IUdR-substituted phage." @default.
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- W1592386291 date "1968-09-01" @default.
- W1592386291 modified "2023-09-29" @default.
- W1592386291 title "The Ability of Phage Containing 5-Iodo-2′-deoxyuridine-substituted Deoxyribonucleic Acid to Induce Enzymes" @default.
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- W1592386291 doi "https://doi.org/10.1016/s0021-9258(18)93182-0" @default.
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