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- W1592423218 abstract "In the human, sleep and hormonal secretions are under the dual control of circadian rhythmicity and of a homeostatic process relating the depth of sleep to the duration of prior wakefulness. The circadian clock plays a major role in the timings of sleep onset and offset, sleep consolidation, and the distributions of rapid eye movement (REM) sleep. The temporal organization of the secretions of a number of hormones such as melatonin and the hormones of the hypothalamo–pituitary–adrenal axis are also primarily controlled by the circadian pacemaker. On the other hand, the temporal profile of non-REM sleep, in particular slow-wave sleep, and a number of hormones such as prolactin and growth hormone are primarily controlled by the homeostatic process. Normal aging is commonly associated with profound alterations of both the homeostatic process and the circadian pacemaker, which are, however, chronologically dissociated. Alterations of the homeostatic process, as assessed by exponential decreases in slow-wave sleep and in nocturnal growth hormone secretion, are essentially complete by midlife. In contrast, alterations of the circadian pacemaker, as assessed in particular by modifications of REM sleep and of the glucocorticoid secretory profiles, occur essentially from 50 years onward. Strategies for preventing or limiting such alterations should take into account this dissociated chronology of aging. Pharmacological approaches to restore normal sleep could represent an indirect form of hormonal therapy with possible beneficial health effects. © 2001 Academic Press." @default.
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- W1592423218 date "2001-01-01" @default.
- W1592423218 modified "2023-09-28" @default.
- W1592423218 title "Sleep and Hormonal Rhythms in Humans" @default.
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- W1592423218 doi "https://doi.org/10.1016/b978-012351830-9/50062-7" @default.
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