Matches in SemOpenAlex for { <https://semopenalex.org/work/W1592455657> ?p ?o ?g. }
- W1592455657 abstract "The objective of these studies was to evaluate possible airway inflammation and remodeling at the bronchial level in cross-country skiers without a prior diagnosis of asthma, and relate the findings to patients with mild chronic asthma and patients with newly diagnosed asthma. We also studied the association of airway inflammatory changes and bronchial hyperresponsivess (BHR), and treatment effects in cross-country skiers and in patients with newly diagnosed asthma. Differences were also studied in airway inflammation between atopic and nonatopic asthmatics. Bronchial biopsies were obtained from the subjects by flexible bronchoscopy, and the inflammatory cells (eosinophils, mast cells, T-lymphocytes, macrophages, and neutrophils) were identified by immunohistochemistry. Tenascin (Tn) immunoreactivity in the bronchial basement membrane (BM) was identified by immunofluorescence staining. Cell densities were counted and the thickness of Tn immunoreactivity was measured. Lung function was measured with spirometry, and BHR was assessed by methacholine (skiers) or histamine (asthmatics) challenges. Skiers with BHR and asthma-like symptoms were recruited to a drug-intervention study. Skiers were given treatment with placebo or budesonide (400 μg bid), and bronchial biopsies were obtained after 22 weeks’ treatment. Patients with newly diagnosed asthma were given treatment for 16 weeks with placebo, salmeterol (SLM) (50 μg bid), fluticasone propionate (FP) (250 μg bid), or disodium cromoglicate (DSCG) (5 mg qid). Bronchial biopsies were obtained at baseline and at the end of the treatment period. In the skiers a distinct airway inflammation was evident. In their bronchial biopsy specimens, T-lymphocyte, macrophage, and eosinophil counts were, respectively greater by 43-fold (P 0.001), 63-fold (P<0.001), and 8-fold (P<0.001) in asthmatic subjects than in controls. In skiers, neutrophil counts were more than 2-fold greater than in asthmatic subjects (P<0.05). Tn expression was higher in skiers vs. controls and lower in skiers vs. mild asthmatics. There were no significant changes between hyperresponsive and nonhyperresponsive skier in the inflammatory cell counts or Tn expression. Treatment with inhaled budesonide did not attenuate asthma-like symptoms, the inflammatory cell infiltration, or basement membrane tenascin expression in the skiers. In newly diagnosed asthmatic patients, SLM, FP, and DSCG reduced asthma symptoms, and need for rescue medication (P<0.04). BHR was reduced by doubling doses 2.78, 5.22, and 1.35 respectively (all P<0.05). SLM and placebo had no effect on cell counts or Tn expression. FP and DSCG reduced eosinophil counts in the bronchial biopsy specimens (P<0.02 and <0.048, respectively). No significant change in tenascin expression appeared in any treatment group. Regarding to atopy, no significant differences existed in the inflammatory cell counts in the bronchial mucosa of subjects with newly diagnosed asthma or in elite cross country skiers. Tn expression in the BM was significantly higher in atopic asthma than in those with nonatopic asthma. Airway inflammation occurred in elite cross-country skiers with and without respiratory symptoms or BHR. Their inflammatory cell pattern differed from that in asthma. Infiltration with eosinophils, macrophages, and mast cells was milder, but lymphocyte counts did not differ from counts in asthmatic airways. Neutrophilic infiltration was more extensive in skiers than in asthmatics. Remodeling took place in the skiers’ airways, as reflected by increased expression of BM tenascin These inflammatory changes and Tn expression may be caused by prolonged exposure of the lower airways to inadequately humidified cold air. Inflammatory changes and remodeling were not reversed with anti-inflammatory treatment. In contrast, in patients with newly diagnosed asthma, anti-inflammatory treatment did attenuate eosinophilic inflammation in the bronchial mucosa. In skiers, antiinflammatory treatment did not attenuate BHR as it did in asthmatic patients. The BHR in skiers was attenuated spontaneously during placebo treatment, with no difference from budesonide treatment. Lower training intensity during the treatment period may explain this spontaneous decrease in BHR. The origin of BHR probably differs in skiers and in asthmatics. No significant association between BHR and inflammatory cell counts or between BHR and Tn expression was evident in cross-country skiers or asthmatic subjects. Airway remodeling differed between atopic and nonatopic asthma. As opposed to nonatopic asthma, Tn expression was higher in atopic asthma and is related to inflammatory cell densities." @default.
- W1592455657 created "2016-06-24" @default.
- W1592455657 creator A5076777567 @default.
- W1592455657 date "2008-06-13" @default.
- W1592455657 modified "2023-09-23" @default.
- W1592455657 title "Airway Inflammation and Bronchial Hyperresponsiveness in Elite Cross-Country Skiers and in Patients with Newly Diagnosed Asthma : A Bronchial Biopsy Study" @default.
- W1592455657 cites W1235046880 @default.
- W1592455657 cites W1480920464 @default.
- W1592455657 cites W1515328513 @default.
- W1592455657 cites W1523155803 @default.
- W1592455657 cites W1581017274 @default.
- W1592455657 cites W1589665332 @default.
- W1592455657 cites W1602993951 @default.
- W1592455657 cites W1609066286 @default.
- W1592455657 cites W1657740120 @default.
- W1592455657 cites W1811488600 @default.
- W1592455657 cites W1832658555 @default.
- W1592455657 cites W1843291397 @default.
- W1592455657 cites W184596020 @default.
- W1592455657 cites W1872391424 @default.
- W1592455657 cites W1891391790 @default.
- W1592455657 cites W1894440115 @default.
- W1592455657 cites W1905634159 @default.
- W1592455657 cites W1919677047 @default.
- W1592455657 cites W192372067 @default.
- W1592455657 cites W1945512486 @default.
- W1592455657 cites W1952303879 @default.
- W1592455657 cites W1959535291 @default.
- W1592455657 cites W1965911422 @default.
- W1592455657 cites W1966364214 @default.
- W1592455657 cites W1966402203 @default.
- W1592455657 cites W1967518696 @default.
- W1592455657 cites W1967847611 @default.
- W1592455657 cites W1967984987 @default.
- W1592455657 cites W1968723792 @default.
- W1592455657 cites W1968870603 @default.
- W1592455657 cites W1969211572 @default.
- W1592455657 cites W1969594061 @default.
- W1592455657 cites W1970395908 @default.
- W1592455657 cites W1970628467 @default.
- W1592455657 cites W1971569966 @default.
- W1592455657 cites W1971766874 @default.
- W1592455657 cites W1973850387 @default.
- W1592455657 cites W1974371579 @default.
- W1592455657 cites W1975022088 @default.
- W1592455657 cites W1975777122 @default.
- W1592455657 cites W1975790353 @default.
- W1592455657 cites W1976303476 @default.
- W1592455657 cites W1979903363 @default.
- W1592455657 cites W1980638060 @default.
- W1592455657 cites W1981146638 @default.
- W1592455657 cites W1981991229 @default.
- W1592455657 cites W1982060405 @default.
- W1592455657 cites W1982824483 @default.
- W1592455657 cites W1983730237 @default.
- W1592455657 cites W1985033634 @default.
- W1592455657 cites W198504550 @default.
- W1592455657 cites W1985176515 @default.
- W1592455657 cites W1985190643 @default.
- W1592455657 cites W1985521062 @default.
- W1592455657 cites W1985822363 @default.
- W1592455657 cites W1985977922 @default.
- W1592455657 cites W1987183940 @default.
- W1592455657 cites W1988145495 @default.
- W1592455657 cites W1988563955 @default.
- W1592455657 cites W1989236016 @default.
- W1592455657 cites W1989260226 @default.
- W1592455657 cites W1989526182 @default.
- W1592455657 cites W1989626763 @default.
- W1592455657 cites W1991246311 @default.
- W1592455657 cites W1991267104 @default.
- W1592455657 cites W1991316167 @default.
- W1592455657 cites W1991903923 @default.
- W1592455657 cites W1993745694 @default.
- W1592455657 cites W1993997407 @default.
- W1592455657 cites W1994677344 @default.
- W1592455657 cites W1994692310 @default.
- W1592455657 cites W1995685224 @default.
- W1592455657 cites W1995996876 @default.
- W1592455657 cites W1996425248 @default.
- W1592455657 cites W1996449825 @default.
- W1592455657 cites W1996800018 @default.
- W1592455657 cites W1998616887 @default.
- W1592455657 cites W1998782208 @default.
- W1592455657 cites W1999780808 @default.
- W1592455657 cites W1999788260 @default.
- W1592455657 cites W1999970608 @default.
- W1592455657 cites W2000746716 @default.
- W1592455657 cites W2001137099 @default.
- W1592455657 cites W2002211843 @default.
- W1592455657 cites W2002321755 @default.
- W1592455657 cites W2002760834 @default.
- W1592455657 cites W2003997169 @default.
- W1592455657 cites W2004216239 @default.
- W1592455657 cites W2006370491 @default.
- W1592455657 cites W2006761383 @default.
- W1592455657 cites W2007318853 @default.
- W1592455657 cites W2007646135 @default.
- W1592455657 cites W2009333155 @default.
- W1592455657 cites W2012317776 @default.