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- W1592682743 abstract "Historically, polytene chromosomes provided an important link between the genetic map and the physical location of deletions, insertions, inversions, and translocations on the genetic map. More recently, these chromosomes have provided an efficient means of analyzing both the global distribution of particular proteins on chromosomes and the recruitment of particular proteins to specific chromosomal loci that are undergoing changes in activity. Indirect immunofluorescence staining of polytenes provides a rapid way of determining the genomic distribution of chromosomal proteins. This was first recognized in early experiments in the laboratories of Elgin and Bautz. These early experiments revealed with spectacular clarity the location of RNA polymerase II and its strong association with chromosomal puffs and interbands, and histones and their concentration in DNA-rich chromosomal bands. More recently, antibodies have been used to investigate a variety of protein interactions with chromatin in vivo. In short, immunofluorescent staining of polytene chromosomes is a reliable, fast, and convenient means of assessing the genome-wide distribution of chromatin binding proteins. The availability of transgenic flies and the ability to treat salivary glands with drugs makes it a powerful tool to investigate the function and dynamics of transcription and other factors in vivo." @default.
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- W1592682743 date "2003-01-01" @default.
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- W1592682743 title "Indirect Immunofluorescent Labeling of Drosophila Polytene Chromosomes: Visualizing Protein Interactions with Chromatin In Vivo" @default.
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- W1592682743 doi "https://doi.org/10.1016/s0076-6879(03)76026-1" @default.
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