FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1592692212> ?p ?o ?g. }

• W1592692212 endingPage "8" @default.
• W1592692212 startingPage "1" @default.
• W1592692212 abstract "The issue of herb-drug interactions has been widely reported. Herbal ingredients can activate nuclear receptors and further induce the gene expression alteration of drug-metabolizing enzyme and/or transporter. Therefore, the herb-drug interaction will happen when the herbs and drugs are coadministered. This kind of interaction is called inductive herb-drug interactions. Pregnane X Receptor (PXR) and drug-metabolizing target genes are involved in most of inductive herb-drug interactions. To predict this kind of herb-drug interaction, the protocol could be simplified to only screen agonists of PXR from herbs because the relations of drugs with their metabolizing enzymes are well studied. Here, a combinational in silico strategy of pharmacophore modelling and docking-based rank aggregation (DRA) was employed to identify PXR’s agonists. Firstly, 305 ingredients were screened out from 820 ingredients as candidate agonists of PXR with our pharmacophore model. Secondly, DRA was used to rerank the result of pharmacophore filtering. To validate our prediction, a curated herb-drug interaction database was built, which recorded 380 herb-drug interactions. Finally, among the top 10 herb ingredients from the ranking list, 6 ingredients were reported to involve in herb-drug interactions. The accuracy of our method is higher than other traditional methods. The strategy could be extended to studies on other inductive herb-drug interactions." @default.
• W1592692212 created "2016-06-24" @default.
• W1592692212 creator A5010167624 @default.
• W1592692212 creator A5025886127 @default.
• W1592692212 creator A5025975675 @default.
• W1592692212 creator A5053297767 @default.
• W1592692212 creator A5060948898 @default.
• W1592692212 creator A5069883815 @default.
• W1592692212 date "2015-01-01" @default.
• W1592692212 modified "2023-10-14" @default.
• W1592692212 title "Screening Ingredients from Herbs against Pregnane X Receptor in the Study of Inductive Herb-Drug Interactions: Combining Pharmacophore and Docking-Based Rank Aggregation" @default.
• W1592692212 cites W1966628449 @default.
• W1592692212 cites W1967989141 @default.
• W1592692212 cites W1969763365 @default.
• W1592692212 cites W1981873124 @default.
• W1592692212 cites W1991853537 @default.
• W1592692212 cites W2021008273 @default.
• W1592692212 cites W2021206718 @default.
• W1592692212 cites W2021686544 @default.
• W1592692212 cites W2024990640 @default.
• W1592692212 cites W2026375486 @default.
• W1592692212 cites W2026429211 @default.
• W1592692212 cites W2027708448 @default.
• W1592692212 cites W2040324065 @default.
• W1592692212 cites W2042250216 @default.
• W1592692212 cites W2053768822 @default.
• W1592692212 cites W2054525309 @default.
• W1592692212 cites W2055332875 @default.
• W1592692212 cites W2056466688 @default.
• W1592692212 cites W2059488029 @default.
• W1592692212 cites W2063370801 @default.
• W1592692212 cites W2063628660 @default.
• W1592692212 cites W2071850217 @default.
• W1592692212 cites W2084462922 @default.
• W1592692212 cites W2085294587 @default.
• W1592692212 cites W2090148783 @default.
• W1592692212 cites W2096864392 @default.
• W1592692212 cites W2098971704 @default.
• W1592692212 cites W2109415161 @default.
• W1592692212 cites W2114268578 @default.
• W1592692212 cites W2114756989 @default.
• W1592692212 cites W2121895929 @default.
• W1592692212 cites W2124371850 @default.
• W1592692212 cites W2126131484 @default.
• W1592692212 cites W2130033866 @default.
• W1592692212 cites W2131792166 @default.
• W1592692212 cites W2133425774 @default.
• W1592692212 cites W2136560821 @default.
• W1592692212 cites W2142105589 @default.
• W1592692212 cites W2151268696 @default.
• W1592692212 cites W2154120770 @default.
• W1592692212 cites W2157122545 @default.
• W1592692212 cites W2166931842 @default.
• W1592692212 cites W2170250016 @default.
• W1592692212 cites W2171932083 @default.
• W1592692212 cites W2327807854 @default.
• W1592692212 cites W2951572837 @default.
• W1592692212 cites W9262009 @default.
• W1592692212 cites W99605343 @default.
• W1592692212 doi "https://doi.org/10.1155/2015/657159" @default.
• W1592692212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4538340" @default.
• W1592692212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26339628" @default.
• W1592692212 hasPublicationYear "2015" @default.
• W1592692212 type Work @default.
• W1592692212 sameAs 1592692212 @default.
• W1592692212 citedByCount "10" @default.
• W1592692212 countsByYear W15926922122016 @default.
• W1592692212 countsByYear W15926922122018 @default.
• W1592692212 countsByYear W15926922122020 @default.
• W1592692212 countsByYear W15926922122021 @default.
• W1592692212 countsByYear W15926922122022 @default.
• W1592692212 countsByYear W15926922122023 @default.
• W1592692212 crossrefType "journal-article" @default.
• W1592692212 hasAuthorship W1592692212A5010167624 @default.
• W1592692212 hasAuthorship W1592692212A5025886127 @default.
• W1592692212 hasAuthorship W1592692212A5025975675 @default.
• W1592692212 hasAuthorship W1592692212A5053297767 @default.
• W1592692212 hasAuthorship W1592692212A5060948898 @default.
• W1592692212 hasAuthorship W1592692212A5069883815 @default.
• W1592692212 hasBestOaLocation W15926922121 @default.
• W1592692212 hasConcept C104317684 @default.
• W1592692212 hasConcept C132040763 @default.
• W1592692212 hasConcept C159110408 @default.
• W1592692212 hasConcept C185592680 @default.
• W1592692212 hasConcept C2775905019 @default.
• W1592692212 hasConcept C2779824472 @default.
• W1592692212 hasConcept C2780035454 @default.
• W1592692212 hasConcept C2991655182 @default.
• W1592692212 hasConcept C41685203 @default.
• W1592692212 hasConcept C55493867 @default.
• W1592692212 hasConcept C556039675 @default.
• W1592692212 hasConcept C56173144 @default.
• W1592692212 hasConcept C63932345 @default.
• W1592692212 hasConcept C70721500 @default.
• W1592692212 hasConcept C71240020 @default.
• W1592692212 hasConcept C71924100 @default.
• W1592692212 hasConcept C86339819 @default.
• W1592692212 hasConcept C86803240 @default.

• next