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• W1592823291 abstract "Blastocystis hominis undergo apoptosis after treatment with a cytotoxic monoclonal antibody (MAb), 1D5, by mechanisms that are not fully understood, although our previous study demonstrated that caspase-3-like protease activity is involved. To elucidate the mechanism of MAb 1D5-induced apoptosis, we inhibited Blastocystis caspase-3-like protease to investigate if there would be a concomitant decrease in in situ DNA fragmentation. However, MAb 1D5-induced apoptosis, evidenced by DNA fragmentation, was not completely blocked by pretreating with specific caspase-3 inhibitor, Ac-DEVD-CHO, indicating that caspase-independent apoptotic pathways might also be involved. Our results also revealed that the treatment with MAb 1D5 resulted in the loss of mitochondrial membrane potential (ΔΨm), independent of Ac-DEVD-CHO pretreatment. In conclusion, this study demonstrates that MAb 1D5-induced apoptosis in B. hominis is not wholly dependent on caspase-3-like protease activity and is associated with mitochondrial dysregulation. This is the first report showing evidence for complex apoptotic pathways in a unicellular parasite." @default.
• W1592823291 created "2016-06-24" @default.
• W1592823291 creator A5027933661 @default.
• W1592823291 creator A5043093379 @default.
• W1592823291 date "2004-01-01" @default.
• W1592823291 modified "2023-10-17" @default.
• W1592823291 title "Caspase-3-like protease influences but is not essential for DNA fragmentation in Blastocystis undergoing apoptosis" @default.
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• W1592823291 doi "https://doi.org/10.1078/0171-9335-00411" @default.
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